ID A0A0A0L762_CUCSA Unreviewed; 1189 AA.
AC A0A0A0L762;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=Csa_3G221760 {ECO:0000313|EMBL:KGN57593.1};
OS Cucumis sativus (Cucumber).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis.
OX NCBI_TaxID=3659 {ECO:0000313|EMBL:KGN57593.1, ECO:0000313|Proteomes:UP000029981};
RN [1] {ECO:0000313|EMBL:KGN57593.1, ECO:0000313|Proteomes:UP000029981}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. 9930 {ECO:0000313|Proteomes:UP000029981};
RX PubMed=19881527; DOI=10.1038/ng.475;
RA Huang S., Li R., Zhang Z., Li L., Gu X., Fan W., Lucas W.J., Wang X.,
RA Xie B., Ni P., Ren Y., Zhu H., Li J., Lin K., Jin W., Fei Z., Li G.,
RA Staub J., Kilian A., van der Vossen E.A., Wu Y., Guo J., He J., Jia Z.,
RA Ren Y., Tian G., Lu Y., Ruan J., Qian W., Wang M., Huang Q., Li B.,
RA Xuan Z., Cao J., Asan null, Wu Z., Zhang J., Cai Q., Bai Y., Zhao B.,
RA Han Y., Li Y., Li X., Wang S., Shi Q., Liu S., Cho W.K., Kim J.Y., Xu Y.,
RA Heller-Uszynska K., Miao H., Cheng Z., Zhang S., Wu J., Yang Y., Kang H.,
RA Li M., Liang H., Ren X., Shi Z., Wen M., Jian M., Yang H., Zhang G.,
RA Yang Z., Chen R., Liu S., Li J., Ma L., Liu H., Zhou Y., Zhao J., Fang X.,
RA Li G., Fang L., Li Y., Liu D., Zheng H., Zhang Y., Qin N., Li Z., Yang G.,
RA Yang S., Bolund L., Kristiansen K., Zheng H., Li S., Zhang X., Yang H.,
RA Wang J., Sun R., Zhang B., Jiang S., Wang J., Du Y., Li S.;
RT "The genome of the cucumber, Cucumis sativus L.";
RL Nat. Genet. 41:1275-1281(2009).
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446}.
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DR EMBL; CM002924; KGN57593.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0A0L762; -.
DR SMR; A0A0A0L762; -.
DR STRING; 3659.A0A0A0L762; -.
DR EnsemblPlants; KGN57593; KGN57593; Csa_3G221760.
DR Gramene; KGN57593; KGN57593; Csa_3G221760.
DR eggNOG; KOG0351; Eukaryota.
DR OMA; VNWSDHA; -.
DR Proteomes; UP000029981; Chromosome 3.
DR GO; GO:0005694; C:chromosome; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0009378; F:four-way junction helicase activity; IBA:GO_Central.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006268; P:DNA unwinding involved in DNA replication; IBA:GO_Central.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR CDD; cd17920; DEXHc_RecQ; 1.
DR CDD; cd18794; SF2_C_RecQ; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR InterPro; IPR001763; Rhodanese-like_dom.
DR InterPro; IPR018982; RQC_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710:SF153; ATP-DEPENDENT DNA HELICASE Q-LIKE 4A; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR Pfam; PF09382; RQC; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00341; HRDC; 1.
DR SMART; SM00956; RQC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50967; HRDC; 1.
DR PROSITE; PS50206; RHODANESE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000029981}.
FT DOMAIN 446..621
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 646..791
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 661..703
FT /note="Rhodanese"
FT /evidence="ECO:0000259|PROSITE:PS50206"
FT DOMAIN 1005..1087
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 93..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1085..1157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1098..1135
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1136..1150
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1189 AA; 134623 MW; 00E94556E66D2067 CRC64;
MNWLEHSKAH KDFSCQKKFL CSNFLFCLPE QKPSTTGSTD TGNLACQMQN LQRIQRSQVE
KAWNALSNFQ ISCRHYAKPG NTRQVKDVFS DHPADTGRIT SNSLSDANAS SHHKKVHRNF
SEYSVDTTKP SSFGSNLSAS SNIQVMEGQN DVDGNNMARL RTINNSHFQR VDGSVIFATN
QKNICSSFLE DEDDKIIENI DVDQIVEQYQ SQSACTPQPS VSKLPPITPI IEKDNVARQE
ESNYPDELCT NCSHGFKIEL CPEASSHLQE LKDRLISISN DLLDNVNNLS PVQIDKLRQE
RVHLNKQIQL LERHISLDAV NEERRRSHLF ATTVTPKTFH FETPPGVEFR TDAKLNTSYV
HQDFEPRRIE PWNSMGSSYV DERFGMSSGP VEREPYIPKV IDVNYIEGSN DKKWSSRNFS
WTKELEANNK KVFGNHSFRP NQREVINATM SGYDVFVLMP TGGGKSLTYQ LPALICPGVT
LVISPLVSLI QDQIMHLIQA NISAAYLSAN MEWSEQQEIF RDLSSDCSKY KLLYVTPEKV
AKSDVLLRHL ESLNARHLLA RIVIDEAHCV SQWGHDFRPD YQGLGILKQK FPKIPVLALT
ATATASVKED VVQALGLINC IIFRQSFNRP NLWYSVIPKT KKCVDDIDKF IKENHFDECG
IVYCLSRMDC EKVAERLQEC GHKAAFYHGS MDPAQRSFIQ KQWSKDEINI ICATVAFGMG
INKPDVRFVI HHSLPKSIEG YHQECGRAGR DGLRSSCVLY YSYSDYIRVK HMISQGATEQ
SPLVSGYNRT NLGSSGRILE TNTENLLRMV SYCENDVDCR RLLQLVHFGE KFDPGNCKKT
CDNCLKSTNL IEKDVTDISK QLVDLVRSMG QQFSSAHILE VYRGSLSQFV KKHRHEKLSL
HGTGKHLLKS EASRILHHLV IEDILVEEVR KSDIYGSVSS LLKVNETKVR SLLNGGQRIK
LRFPSSTKTN KLSKFEMTPA KGSLVSGKMY PNIDTPAQPQ SEVDVQLSAE LYSSLRMLRT
NLVKEAADGV MAYHIFGNAT LQQISRRVPR SKEELLDING IGKAKVSKYG DRILETIEST
IKEFYGAGKN GSNSNDSNDS GKRRRGGNKD KDEYLDENDA TKSFDRSKKR ATNIQNKDPN
VHNSSMPEHP DQFFDSELDF DDSHYEIRDL ELNNNLDHGN DGRVLPSWS
//
