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Database: UniProt
Entry: A0A0A0LBW6_CUCSA
LinkDB: A0A0A0LBW6_CUCSA
Original site: A0A0A0LBW6_CUCSA 
ID   A0A0A0LBW6_CUCSA        Unreviewed;       599 AA.
AC   A0A0A0LBW6;
DT   07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 1.
DT   18-SEP-2019, entry version 25.
DE   RecName: Full=D-3-phosphoglycerate dehydrogenase {ECO:0000256|RuleBase:RU363003};
DE            EC=1.1.1.95 {ECO:0000256|RuleBase:RU363003};
GN   ORFNames=Csa_3G199630 {ECO:0000313|EMBL:KGN57501.1};
OS   Cucumis sativus (Cucumber).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae;
OC   Pentapetalae; rosids; fabids; Cucurbitales; Cucurbitaceae;
OC   Benincaseae; Cucumis.
OX   NCBI_TaxID=3659 {ECO:0000313|EMBL:KGN57501.1, ECO:0000313|Proteomes:UP000029981};
RN   [1] {ECO:0000313|EMBL:KGN57501.1, ECO:0000313|Proteomes:UP000029981}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=19881527; DOI=10.1038/ng.475;
RA   Huang S., Li R., Zhang Z., Li L., Gu X., Fan W., Lucas W.J., Wang X.,
RA   Xie B., Ni P., Ren Y., Zhu H., Li J., Lin K., Jin W., Fei Z., Li G.,
RA   Staub J., Kilian A., van der Vossen E.A., Wu Y., Guo J., He J.,
RA   Jia Z., Ren Y., Tian G., Lu Y., Ruan J., Qian W., Wang M., Huang Q.,
RA   Li B., Xuan Z., Cao J., Asan null, Wu Z., Zhang J., Cai Q., Bai Y.,
RA   Zhao B., Han Y., Li Y., Li X., Wang S., Shi Q., Liu S., Cho W.K.,
RA   Kim J.Y., Xu Y., Heller-Uszynska K., Miao H., Cheng Z., Zhang S.,
RA   Wu J., Yang Y., Kang H., Li M., Liang H., Ren X., Shi Z., Wen M.,
RA   Jian M., Yang H., Zhang G., Yang Z., Chen R., Liu S., Li J., Ma L.,
RA   Liu H., Zhou Y., Zhao J., Fang X., Li G., Fang L., Li Y., Liu D.,
RA   Zheng H., Zhang Y., Qin N., Li Z., Yang G., Yang S., Bolund L.,
RA   Kristiansen K., Zheng H., Li S., Zhang X., Yang H., Wang J., Sun R.,
RA   Zhang B., Jiang S., Wang J., Du Y., Li S.;
RT   "The genome of the cucumber, Cucumis sativus L.";
RL   Nat. Genet. 41:1275-1281(2009).
RN   [2] {ECO:0000313|EMBL:KGN57501.1, ECO:0000313|Proteomes:UP000029981}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=19495411; DOI=10.1371/journal.pone.0005795;
RA   Ren Y., Zhang Z., Liu J., Staub J.E., Han Y., Cheng Z., Li X., Lu J.,
RA   Miao H., Kang H., Xie B., Gu X., Wang X., Du Y., Jin W., Huang S.;
RT   "An integrated genetic and cytogenetic map of the cucumber genome.";
RL   PLoS ONE 4:E5795-E5795(2009).
RN   [3] {ECO:0000313|EMBL:KGN57501.1, ECO:0000313|Proteomes:UP000029981}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20565788; DOI=10.1186/1471-2164-11-384;
RA   Guo S., Zheng Y., Joung J.G., Liu S., Zhang Z., Crasta O.R.,
RA   Sobral B.W., Xu Y., Huang S., Fei Z.;
RT   "Transcriptome sequencing and comparative analysis of cucumber flowers
RT   with different sex types.";
RL   BMC Genomics 11:384-384(2010).
RN   [4] {ECO:0000313|EMBL:KGN57501.1, ECO:0000313|Proteomes:UP000029981}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22047402; DOI=10.1186/1471-2164-12-540;
RA   Li Z., Zhang Z., Yan P., Huang S., Fei Z., Lin K.;
RT   "RNA-Seq improves annotation of protein-coding genes in the cucumber
RT   genome.";
RL   BMC Genomics 12:540-540(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate +
CC         H(+) + NADH; Xref=Rhea:RHEA:12641, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:18110, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:58272; EC=1.1.1.95;
CC         Evidence={ECO:0000256|RuleBase:RU363003};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-serine biosynthesis; L-serine
CC       from 3-phospho-D-glycerate: step 1/3.
CC       {ECO:0000256|RuleBase:RU363003}.
CC   -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC       dehydrogenase family. {ECO:0000256|RuleBase:RU363003}.
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DR   EMBL; CM002924; KGN57501.1; -; Genomic_DNA.
DR   RefSeq; XP_004140713.1; XM_004140665.2.
DR   STRING; 3659.XP_004161437.1; -.
DR   EnsemblPlants; KGN57501; KGN57501; Csa_3G199630.
DR   GeneID; 101221689; -.
DR   Gramene; KGN57501; KGN57501; Csa_3G199630.
DR   KEGG; csv:101221689; -.
DR   KO; K00058; -.
DR   OMA; NIAGMQV; -.
DR   UniPathway; UPA00135; UER00196.
DR   Proteomes; UP000029981; Chromosome 3.
DR   GO; GO:0051287; F:NAD binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004617; F:phosphoglycerate dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006564; P:L-serine biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1330.90; -; 1.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR015878; Ado_hCys_hydrolase_NAD-bd.
DR   InterPro; IPR029009; ASB_dom_sf.
DR   InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR   InterPro; IPR029753; D-isomer_DH_CS.
DR   InterPro; IPR029752; D-isomer_DH_CS1.
DR   InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR006236; PGDH.
DR   Pfam; PF00389; 2-Hacid_dh; 1.
DR   Pfam; PF02826; 2-Hacid_dh_C; 1.
DR   Pfam; PF01842; ACT; 1.
DR   SMART; SM00997; AdoHcyase_NAD; 1.
DR   SUPFAM; SSF143548; SSF143548; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR01327; PGDH; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
DR   PROSITE; PS00670; D_2_HYDROXYACID_DH_2; 1.
DR   PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU363003};
KW   Complete proteome {ECO:0000313|Proteomes:UP000029981};
KW   NAD {ECO:0000256|RuleBase:RU363003};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU363003};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029981};
KW   Serine biosynthesis {ECO:0000256|RuleBase:RU363003}.
FT   DOMAIN      527    599       ACT. {ECO:0000259|PROSITE:PS51671}.
SQ   SEQUENCE   599 AA;  63103 MW;  D932DA467D0BBAFC CRC64;
     MAASASPTLR TPSLRNSLFS SLSSKLPLPS AFSVNLRPRS VAAPRFVVLV SASLNAKPTV
     LVAEKLGEAG LDLLKEFANV DCSYNLSPEE LCTKISLCDA LIVRSGTKVS REVFESSGGR
     LKVVGRAGVG IDNVDLAAAT EHGCLVVNAP TANTVAAAEH GIALLTAMAR NVAQADASVK
     AGKWQRNKYV GVSLVGKTLA VMGFGKVGSE VARRAKGLGM HVIAHDPYAP ADRARAIGVE
     LVGFEEAIAT ADFISLHMPL TPATSKILND ENFAKMKKGV RIVNVARGGV IDEEALVRAL
     DAGIVAQAAL DVFTVEPPPK DSKLIQHENV TVTPHLGAST MEAQEGVAVE IAEAVVGALK
     GELAATAVNA PMVPAEVLTE LKPFVELAEK LGRLAVQLVA GGSGVKTVKV TYASSRAPDD
     LDTRLLRAMI TKGLIEPISS VFVNLVNADF TAKQRGLRIT EERVIIDGSP EKPLEYIQVQ
     IANVESKFAS AISDSGEIKV EGLVKDGVPH LTKVGSFEVD VSLEGSIILC RQVDQPGMIG
     KVGSILGEEN VNVSFMSVGR IAPRKQAVMA IGVDEQPSKE SLKRIGDVPA IEEFVFLKL
//
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