ID A0A0A0LID2_CUCSA Unreviewed; 311 AA.
AC A0A0A0LID2;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Glyoxylate/succinic semialdehyde reductase 2, chloroplastic {ECO:0008006|Google:ProtNLM};
GN ORFNames=Csa_3G848210 {ECO:0000313|EMBL:KGN59811.1};
OS Cucumis sativus (Cucumber).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis.
OX NCBI_TaxID=3659 {ECO:0000313|EMBL:KGN59811.1, ECO:0000313|Proteomes:UP000029981};
RN [1] {ECO:0000313|EMBL:KGN59811.1, ECO:0000313|Proteomes:UP000029981}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. 9930 {ECO:0000313|Proteomes:UP000029981};
RX PubMed=19881527; DOI=10.1038/ng.475;
RA Huang S., Li R., Zhang Z., Li L., Gu X., Fan W., Lucas W.J., Wang X.,
RA Xie B., Ni P., Ren Y., Zhu H., Li J., Lin K., Jin W., Fei Z., Li G.,
RA Staub J., Kilian A., van der Vossen E.A., Wu Y., Guo J., He J., Jia Z.,
RA Ren Y., Tian G., Lu Y., Ruan J., Qian W., Wang M., Huang Q., Li B.,
RA Xuan Z., Cao J., Asan null, Wu Z., Zhang J., Cai Q., Bai Y., Zhao B.,
RA Han Y., Li Y., Li X., Wang S., Shi Q., Liu S., Cho W.K., Kim J.Y., Xu Y.,
RA Heller-Uszynska K., Miao H., Cheng Z., Zhang S., Wu J., Yang Y., Kang H.,
RA Li M., Liang H., Ren X., Shi Z., Wen M., Jian M., Yang H., Zhang G.,
RA Yang Z., Chen R., Liu S., Li J., Ma L., Liu H., Zhou Y., Zhao J., Fang X.,
RA Li G., Fang L., Li Y., Liu D., Zheng H., Zhang Y., Qin N., Li Z., Yang G.,
RA Yang S., Bolund L., Kristiansen K., Zheng H., Li S., Zhang X., Yang H.,
RA Wang J., Sun R., Zhang B., Jiang S., Wang J., Du Y., Li S.;
RT "The genome of the cucumber, Cucumis sativus L.";
RL Nat. Genet. 41:1275-1281(2009).
CC -!- SIMILARITY: Belongs to the HIBADH-related family. NP60 subfamily.
CC {ECO:0000256|ARBA:ARBA00007598}.
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DR EMBL; CM002924; KGN59811.1; -; Genomic_DNA.
DR RefSeq; XP_004146817.1; XM_004146769.2.
DR AlphaFoldDB; A0A0A0LID2; -.
DR STRING; 3659.A0A0A0LID2; -.
DR EnsemblPlants; KGN59811; KGN59811; Csa_3G848210.
DR GeneID; 101204237; -.
DR Gramene; KGN59811; KGN59811; Csa_3G848210.
DR KEGG; csv:101204237; -.
DR eggNOG; KOG0409; Eukaryota.
DR OMA; NALGCEY; -.
DR OrthoDB; 103196at2759; -.
DR Proteomes; UP000029981; Chromosome 3.
DR GO; GO:0009507; C:chloroplast; IBA:GO_Central.
DR GO; GO:0030267; F:glyoxylate reductase (NADP+) activity; IBA:GO_Central.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43580:SF10; GLYOXYLATE_SUCCINIC SEMIALDEHYDE REDUCTASE 2, CHLOROPLASTIC; 1.
DR PANTHER; PTHR43580; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000029981}.
FT DOMAIN 19..178
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 181..300
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 187
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 311 AA; 32435 MW; 14BE211027A9C13E CRC64;
MSNLGSSLPD ATAAAETLRV GFVGLGIMGS PMAQNLIKSG YDVTVWNRTK SKCDPLINLG
AKYQPSPQEV AACCDVTFAM LADPESALDV ATGENGAASG LSPGKGYVDV STVDGATSKL
ISARIKDTGA LFLEAPVSGS KKPAEDGQLI FLTAGDKALY ERVAPLLDIM GKSKFYLGEV
GNGAAMKLVV NMIMGSMMAS FSEGLLLSEK VGLDPSILVQ VVSQGAISAP MYSLKGPSMV
QSLYPTAFPL KHQQKDLRLA LGLAESVSQS TPIAAAANEL YKVAKSHGLS DQDFSAVIES
LKSKLPHSKT E
//
