ID A0A0A0LWI2_CUCSA Unreviewed; 1546 AA.
AC A0A0A0LWI2;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Lysine-specific demethylase REF6 {ECO:0008006|Google:ProtNLM};
GN ORFNames=Csa_1G050050 {ECO:0000313|EMBL:KGN64366.1};
OS Cucumis sativus (Cucumber).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis.
OX NCBI_TaxID=3659 {ECO:0000313|EMBL:KGN64366.1, ECO:0000313|Proteomes:UP000029981};
RN [1] {ECO:0000313|EMBL:KGN64366.1, ECO:0000313|Proteomes:UP000029981}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. 9930 {ECO:0000313|Proteomes:UP000029981};
RX PubMed=19881527; DOI=10.1038/ng.475;
RA Huang S., Li R., Zhang Z., Li L., Gu X., Fan W., Lucas W.J., Wang X.,
RA Xie B., Ni P., Ren Y., Zhu H., Li J., Lin K., Jin W., Fei Z., Li G.,
RA Staub J., Kilian A., van der Vossen E.A., Wu Y., Guo J., He J., Jia Z.,
RA Ren Y., Tian G., Lu Y., Ruan J., Qian W., Wang M., Huang Q., Li B.,
RA Xuan Z., Cao J., Asan null, Wu Z., Zhang J., Cai Q., Bai Y., Zhao B.,
RA Han Y., Li Y., Li X., Wang S., Shi Q., Liu S., Cho W.K., Kim J.Y., Xu Y.,
RA Heller-Uszynska K., Miao H., Cheng Z., Zhang S., Wu J., Yang Y., Kang H.,
RA Li M., Liang H., Ren X., Shi Z., Wen M., Jian M., Yang H., Zhang G.,
RA Yang Z., Chen R., Liu S., Li J., Ma L., Liu H., Zhou Y., Zhao J., Fang X.,
RA Li G., Fang L., Li Y., Liu D., Zheng H., Zhang Y., Qin N., Li Z., Yang G.,
RA Yang S., Bolund L., Kristiansen K., Zheng H., Li S., Zhang X., Yang H.,
RA Wang J., Sun R., Zhang B., Jiang S., Wang J., Du Y., Li S.;
RT "The genome of the cucumber, Cucumis sativus L.";
RL Nat. Genet. 41:1275-1281(2009).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CM002922; KGN64366.1; -; Genomic_DNA.
DR STRING; 3659.A0A0A0LWI2; -.
DR EnsemblPlants; KGN64366; KGN64366; Csa_1G050050.
DR Gramene; KGN64366; KGN64366; Csa_1G050050.
DR eggNOG; KOG1246; Eukaryota.
DR eggNOG; KOG1721; Eukaryota.
DR OMA; MRFREPS; -.
DR Proteomes; UP000029981; Chromosome 1.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0034647; F:histone H3K4me/H3K4me2/H3K4me3 demethylase activity; IBA:GO_Central.
DR GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProt.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 2.60.120.650; Cupin; 1.
DR InterPro; IPR003347; JmjC_dom.
DR InterPro; IPR003349; JmjN.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR10694; LYSINE-SPECIFIC DEMETHYLASE; 1.
DR PANTHER; PTHR10694:SF38; LYSINE-SPECIFIC DEMETHYLASE REF6; 1.
DR Pfam; PF02373; JmjC; 1.
DR Pfam; PF02375; JmjN; 1.
DR SMART; SM00558; JmjC; 1.
DR SMART; SM00545; JmjN; 1.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR PROSITE; PS51184; JMJC; 1.
DR PROSITE; PS51183; JMJN; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Reference proteome {ECO:0000313|Proteomes:UP000029981};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 19..60
FT /note="JmjN"
FT /evidence="ECO:0000259|PROSITE:PS51183"
FT DOMAIN 194..360
FT /note="JmjC"
FT /evidence="ECO:0000259|PROSITE:PS51184"
FT DOMAIN 1453..1482
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1483..1512
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1513..1544
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 590..610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 743..763
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1067..1106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1223..1262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1331..1425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 593..609
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 747..763
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1331..1350
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1358..1377
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1385..1399
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1546 AA; 173537 MW; 1900741ED1E62241 CRC64;
MAAEPTQEVL SWLKTLPLAP EYHPTLAEFQ DPISYIFKIE KEASKFGICK IVPPVPPSPK
KTVIVNFNKS LAARAAPCSD STNSKSPPTF TTRQQQIGFC PRKTRPVQKS VWQSGEYYTF
QQFEAKAKNF EKSYLKKCTK KGGLSPLEIE TLYWRATLDK PFSVEYANDM PGSAFVPVSA
KMFREAGEGT TLGETAWNMR GVSRAKGSLL KFMKEEIPGV TSPMVYVAMM FSWFAWHVED
HDLHSLNYLH MGAGKTWYGV PRDAAVAFEE VVRVQGYGGE INPLVTFAVL GEKTTVMSPE
VLVSAGVPCC RLVQNAGEFV VTFPRAYHTG FSHGFNCGEA ANIATPEWLN VAKDAAIRRA
SINYPPMVSH YQLLYDLALS SRAPLCTGAE PRSSRLKDKR RSEGDTVIKE LFVQNIVENN
SLLDNLGGGA SVVLLPPGSL ESIYSRLRVG SHLRSKPRFP TGVCSSKEET KSPQSFDYDN
LALENSPVIN RVKGFYSANG PYSTLSERST DNVCASSLRP LNANNERGGN VQSNGLSDQR
LFSCVTCGIL SFACVAIIQP REQAARYLMS ADCSFFNDWV VGSGIASEGI STRDRHPVSS
QQISNSGKRD KCVSDGLYDV PVQAVNRQLP LAGESYEANL NTEKRNETSA LGMLALTYGH
SSDSEEDNAE ADAALNVDDA KLMICSSEDQ YQFENSGLTS GEYSKNTAIL NHDPSSFGIN
SADHMQFQVN DYEEFRRADS KDSFNCSSES EMDGIGSTKK NGLTRYQDSH VNGRSSLDAD
TEKPVFDKST ETVETENMPF APDIDEDFSR LHVFCLEHAK EVEQQLRPIG GVHILLLCHP
DYPKMEAEAK LVAQELSMSH LWTDTIFRDA TQDEEKRIQL ALDSEEAIPG NGDWAVKLGI
NLFYSANLSH SPLYSKQMPY NSVIYNAFGR STSANSSGKP KVYQRRTGKL KRVVAGKWCG
KVWMSNQVHP LLEKRDPQEE DVDIFPSWTM SDEKVDRKSA NIQKNETVKV NRKSAGKRKM
TYGRETIKKA KLVESEDMVS DASVEDCIHQ HHSILRNKQS KFVECNDPMS DDSVEDDSSR
KHGVPVSKGA PYFGTDDTGS DDSLGDRHTL HRGFSGFKLP RWGEIEPSVS DDSLEHYSSQ
HRGKNIKSRT GKYIERQDAL SDECLESGSL KQYRRIPKSK QTKVLKKNAI LHDIRDDSFL
WHHQKPSRIK KAKFIETEDA VSEHSLENSS HQHRSMPQIK PAKHTAWEDA FSDDPDEDDN
SLLQHRNVRS NMQFREITSD DQLDDGANQY SRRVLRRKPV KTETISQMKQ EILRPVKRGA
SQTLKEEFAQ SLKRGGRHTL KLETPQPKIH HATNRRGKRN EKLTDLESED EQPGGPSTRL
RKRTPKPTKL SEAKVKDKKP VAKKKMKTGS SLKTPAGHRD SKARDEESEY LCDIEGCNMS
FGTKQELALH KRNICPVKGC VKKFFSHKYL VQHRRVHMDD RPLKCPWKGC KMTFKWAWAR
TEHIRVHTGA RPYVCAEPGC GQTFRFVSDF SRHKRKTGHS TKKGRG
//
