ID A0A0A0MAH7_9GAMM Unreviewed; 791 AA.
AC A0A0A0MAH7;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:KGO99359.1};
GN ORFNames=N791_09115 {ECO:0000313|EMBL:KGO99359.1};
OS Lysobacter defluvii IMMIB APB-9 = DSM 18482.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Xanthomonadales;
OC Xanthomonadaceae; Lysobacter.
OX NCBI_TaxID=1385515 {ECO:0000313|EMBL:KGO99359.1, ECO:0000313|Proteomes:UP000030003};
RN [1] {ECO:0000313|EMBL:KGO99359.1, ECO:0000313|Proteomes:UP000030003}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IMMIB APB-9 {ECO:0000313|EMBL:KGO99359.1,
RC ECO:0000313|Proteomes:UP000030003};
RA Wang Q., Wang G.;
RT "Genomic analysis of Lysobacter defluvii.";
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGO99359.1}.
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DR EMBL; AVBH01000020; KGO99359.1; -; Genomic_DNA.
DR RefSeq; WP_027068919.1; NZ_AVBH01000020.1.
DR AlphaFoldDB; A0A0A0MAH7; -.
DR STRING; 1385515.GCA_000423325_00365; -.
DR eggNOG; COG1024; Bacteria.
DR eggNOG; COG1250; Bacteria.
DR OrthoDB; 5389341at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000030003; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000030003}.
FT DOMAIN 10..191
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 195..294
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 791 AA; 85663 MW; E9CFD97EF8E64E58 CRC64;
MSEKLLVRRA AVLGAGVMGA QIAAHLVNAG VDTVLFDLPA KEGKPNGVVE QAIARLGKLK
PAPLAEKSLA ARITPANYET GLELLEGCDL VIEAIAERMD WKQDLYRKIA PHVPAHAVLA
SNTSGLGINK LAEVLPGEMR PRFCGVHFFN PPRYMHLAEL IPARSTDDAV MQGLEAFLTT
TLGKGVVYAR DTPNFIGNRI GVFSMLAAMH HTTQFGLGFD TVDALTGPAI GRPKSATYRT
ADVVGLDTMA HVIKTMADTL PEDPWHKYFK APKWLSGLVE KGALGSKSGA GFYTKKGKDI
LVLDLEAQDY RASDQSLDPE VAALLKEREP AKKFAALRAS GHPQAKFLWA CFRDTFHYSA
YHLKDIAETA RDVDLAMRWG YGWSVGPFET WQAAGWKQVA DWIAEDIVAG EAMSNAELPD
WVFDGREGVH SGAGSYSPAR DAMVPRSSNP VYARQRFPDA LLGEKASQGR TVFENDGVRM
WADEGDDIAV VGFKTKMHTV NDHVLDGLQE AIRIAERDFR GLVVWQPKEP FSAGADLAGA
LGLLQAGDVE GFDAMVANFQ RTSMAIKYSQ VPVVVAVRGL ALGGGCEFQM HAARTVLGLE
SYIGLVEAGV GLLPAGGGLK ELAVRASERA GTGGDVFAEL KNVFETVAMA KVSTSALEAK
SLGLARPEDV VVFNAFELLH VAKAQARALA ESGYRPPLPA RAIRVAGDVG IATFRMMLVN
MLEGRFISEH DHEIATRIAT VLCGGEVDRG AVVDEEWLLR LEREHFVALA QMPKTQERIA
HMLKTGKPLR N
//
