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Database: UniProt
Entry: A0A0A0MQL0_MOUSE
LinkDB: A0A0A0MQL0_MOUSE
Original site: A0A0A0MQL0_MOUSE 
ID   A0A0A0MQL0_MOUSE        Unreviewed;       346 AA.
AC   A0A0A0MQL0;
DT   07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT   07-JAN-2015, sequence version 1.
DT   24-JAN-2024, entry version 48.
DE   SubName: Full=Transmembrane protein with EGF-like and two follistatin-like domains 1 {ECO:0000313|Ensembl:ENSMUSP00000121740.2};
DE   Flags: Fragment;
GN   Name=Tmeff1 {ECO:0000313|Ensembl:ENSMUSP00000121740.2,
GN   ECO:0000313|MGI:MGI:1926810};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000121740.2, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000121740.2, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000121740.2,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000121740.2}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000121740.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the tomoregulin family.
CC       {ECO:0000256|ARBA:ARBA00038484}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   AlphaFoldDB; A0A0A0MQL0; -.
DR   ProteomicsDB; 357814; -.
DR   Antibodypedia; 34902; 244 antibodies from 22 providers.
DR   Ensembl; ENSMUST00000130834.8; ENSMUSP00000121740.2; ENSMUSG00000028347.15.
DR   AGR; MGI:1926810; -.
DR   MGI; MGI:1926810; Tmeff1.
DR   VEuPathDB; HostDB:ENSMUSG00000028347; -.
DR   GeneTree; ENSGT00940000160714; -.
DR   HOGENOM; CLU_048579_1_0_1; -.
DR   ChiTaRS; Tmeff1; mouse.
DR   Proteomes; UP000000589; Chromosome 4.
DR   Bgee; ENSMUSG00000028347; Expressed in cortical plate and 246 other cell types or tissues.
DR   ExpressionAtlas; A0A0A0MQL0; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd00104; KAZAL_FS; 2.
DR   Gene3D; 3.30.60.30; -; 2.
DR   Gene3D; 2.10.25.10; Laminin; 1.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR002350; Kazal_dom.
DR   InterPro; IPR036058; Kazal_dom_sf.
DR   PANTHER; PTHR21632:SF3; TOMOREGULIN-1; 1.
DR   PANTHER; PTHR21632; UNCHARACTERIZED; 1.
DR   Pfam; PF07648; Kazal_2; 2.
DR   SMART; SM00280; KAZAL; 2.
DR   SUPFAM; SSF57196; EGF/Laminin; 1.
DR   SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 2.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 1.
DR   PROSITE; PS51465; KAZAL_2; 2.
PE   1: Evidence at protein level;
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW   ProRule:PRU00076}; Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0007829|MaxQB:A0A0A0MQL0,
KW   ECO:0007829|PeptideAtlas:A0A0A0MQL0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        296..318
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          63..110
FT                   /note="Kazal-like"
FT                   /evidence="ECO:0000259|PROSITE:PS51465"
FT   DOMAIN          155..203
FT                   /note="Kazal-like"
FT                   /evidence="ECO:0000259|PROSITE:PS51465"
FT   DOMAIN          237..277
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          112..136
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          325..346
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        331..346
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        267..276
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|Ensembl:ENSMUSP00000121740.2"
SQ   SEQUENCE   346 AA;  37433 MW;  9ADFB31291B24466 CRC64;
     AFCLPGSRAS NQPAGGGGDC PGGRGKSNCS ELNLRESDIR VCDESSCKYG GVCKEDGDGL
     KCACQFQCHT NYIPVCGSNG DTYQNECFLR RAACKHQKDI TVVARGPCYS DNGSGSGEGA
     EEEGSGAGAH RKHSKCGPCK YKAECDEDAE NVGCVCNIDC SGYSFNPVCA SDGSSYNNPC
     FVREASCIKQ EQIDIRHLGH CTDTDDVSLL GKKDDGLQYR PDVKDAGDER EDVYIGSHMP
     CPENLNGYCI HGKCEFIYST QKASCRCESG YTGQHCEKTD FSILYVVPSR QKLTHVLIAA
     IIGAVQIAII VAIVMCITRK CPKNNRGRRQ KQNLGHFTSD TSSRMV
//
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