ID A0A0A0MRE2_HUMAN Unreviewed; 559 AA.
AC A0A0A0MRE2;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 07-JAN-2015, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Double zinc ribbon and ankyrin repeat-containing protein 1 {ECO:0000256|ARBA:ARBA00039856};
GN Name=DZANK1 {ECO:0000313|Ensembl:ENSP00000349774.5};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000349774.5, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000349774.5, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [2] {ECO:0007829|PubMed:18669648}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [3] {ECO:0000313|Ensembl:ENSP00000349774.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AL049646; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL121893; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL158176; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A0A0MRE2; -.
DR SMR; A0A0A0MRE2; -.
DR MassIVE; A0A0A0MRE2; -.
DR PeptideAtlas; A0A0A0MRE2; -.
DR Antibodypedia; 54096; 36 antibodies from 10 providers.
DR Ensembl; ENST00000357236.8; ENSP00000349774.5; ENSG00000089091.17.
DR UCSC; uc061vqa.1; human.
DR HGNC; HGNC:15858; DZANK1.
DR VEuPathDB; HostDB:ENSG00000089091; -.
DR GeneTree; ENSGT00390000000549; -.
DR ChiTaRS; DZANK1; human.
DR Proteomes; UP000005640; Chromosome 20.
DR Bgee; ENSG00000089091; Expressed in sperm and 136 other cell types or tissues.
DR ExpressionAtlas; A0A0A0MRE2; baseline and differential.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR025874; DZR.
DR PANTHER; PTHR16058; DOUBLE ZINC RIBBON AND ANKYRIN REPEAT-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR16058:SF4; DOUBLE ZINC RIBBON AND ANKYRIN REPEAT-CONTAINING PROTEIN 1; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF12773; DZR; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
PE 1: Evidence at protein level;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A0A0MRE2,
KW ECO:0007829|ProteomicsDB:A0A0A0MRE2};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 140..188
FT /note="DZANK-type"
FT /evidence="ECO:0000259|Pfam:PF12773"
SQ SEQUENCE 559 AA; 60857 MW; 4040403DD1786368 CRC64;
MRIQRETDFL KCAHCLAPRP SDPFARFCQE CGSPVPPIFG CRLPPPEGAQ MGLCAECRSL
VPMNTPICVV CEAPLALQLQ PQASLHLKEK VICRACGTGN PAHLRYCVTC EGALPSSQES
MCSGDKAPPP PTQKGGTISC YRCGRWNLWE ASFCGWCGAM LGIPAGCSVC PKCGASNHLS
ARFCGSCGIC VKSLVKLSLD RSLALAAEEP RPFSEPRCAW QSLNIPLPRS DVGTKRDIGT
QTVGLFYPSG KLLAKKEQEL ASQKQRQEKM SDHKPLLTAI SPGRGYWRRQ LDHISAHLRC
YAQNNPEFRA LIAEPRMGKL ISATVHEDGC EVSIRLNYSQ VSNKNLYLNK AVNFSDHLLS
SAAEGDGGLC GSRSSWVSDY SQSTSDTIEK IKRIKNFKTK TFQEKKEQLI PENRLLLKEV
GPTGEGRVSV IEQLLDEGAD PNCCDEDNRP VITVAVMNKH HEAIPVLVQR GADIDQQWGP
LRNTALHEAT LLGLAGREST ATLLGCNASI QKKNAGGQTA YDLALNTGDD LVTSLFAAKF
GQGLEDQLAQ TRSLSLDDC
//
