ID A0A0A0MWE2_PAPAN Unreviewed; 1617 AA.
AC A0A0A0MWE2;
DT 07-JAN-2015, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 3.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Latent transforming growth factor beta binding protein 4 {ECO:0000313|Ensembl:ENSPANP00000009312.3};
GN Name=LTBP4 {ECO:0000313|Ensembl:ENSPANP00000009312.3};
OS Papio anubis (Olive baboon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Papio.
OX NCBI_TaxID=9555 {ECO:0000313|Ensembl:ENSPANP00000009312.3, ECO:0000313|Proteomes:UP000028761};
RN [1] {ECO:0000313|Ensembl:ENSPANP00000009312.3, ECO:0000313|Proteomes:UP000028761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Liu Y.L., Abraham K.A., Akbar H.A., Ali S.A., Anosike U.A., Aqrawi P.A.,
RA Arias F.A., Attaway T.A., Awwad R.A., Babu C.B., Bandaranaike D.B.,
RA Battles P.B., Bell A.B., Beltran B.B., Berhane-Mersha D.B., Bess C.B.,
RA Bickham C.B., Bolden T.B., Carter K.C., Chau D.C., Chavez A.C.,
RA Clerc-Blankenburg K.C., Coyle M.C., Dao M.D., Davila M.L.D.,
RA Davy-Carroll L.D., Denson S.D., Dinh H.D., Fernandez S.F., Fernando P.F.,
RA Forbes L.F., Francis C.F., Francisco L.F., Fu Q.F., Garcia-Iii R.G.,
RA Garrett T.G., Gross S.G., Gubbala S.G., Hirani K.H., Hogues M.H.,
RA Hollins B.H., Jackson L.J., Javaid M.J., Jhangiani S.J., Johnson A.J.,
RA Johnson B.J., Jones J.J., Joshi V.J., Kalu J.K., Khan N.K., Korchina V.K.,
RA Kovar C.K., Lago L.L., Lara F.L., Le T.-K.L., Lee S.L., Legall-Iii F.L.,
RA Lemon S.L., Liu J.L., Liu Y.-S.L., Liyanage D.L., Lopez J.L.,
RA Lorensuhewa L.L., Mata R.M., Mathew T.M., Mercado C.M., Mercado I.M.,
RA Morales K.M., Morgan M.M., Munidasa M.M., Ngo D.N., Nguyen L.N.,
RA Nguyen T.N., Nguyen N.N., Obregon M.O., Okwuonu G.O., Ongeri F.O.,
RA Onwere C.O., Osifeso I.O., Parra A.P., Patil S.P., Perez A.P., Perez Y.P.,
RA Pham C.P., Pu L.-L.P., Puazo M.P., Quiroz J.Q., Rouhana J.R., Ruiz M.R.,
RA Ruiz S.-J.R., Saada N.S., Santibanez J.S., Scheel M.S., Schneider B.S.,
RA Simmons D.S., Sisson I.S., Tang L.-Y.T., Thornton R.T., Tisius J.T.,
RA Toledanes G.T., Trejos Z.T., Usmani K.U., Varghese R.V., Vattathil S.V.,
RA Vee V.V., Walker D.W., Weissenberger G.W., White C.W., Williams A.W.,
RA Woodworth J.W., Wright R.W., Zhu Y.Z., Han Y.H., Newsham I.N.,
RA Nazareth L.N., Worley K.W., Muzny D.M., Rogers J.R., Gibbs R.G.;
RT "Whole Genome Assembly of Papio anubis.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSPANP00000009312.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 9555.ENSPANP00000009312; -.
DR Ensembl; ENSPANT00000003200.3; ENSPANP00000009312.3; ENSPANG00000000994.3.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00940000158234; -.
DR HOGENOM; CLU_001884_0_0_1; -.
DR OMA; NHAGICE; -.
DR Proteomes; UP000028761; Chromosome 20.
DR Bgee; ENSPANG00000000994; Expressed in aorta and 56 other cell types or tissues.
DR ExpressionAtlas; A0A0A0MWE2; baseline.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:Ensembl.
DR GO; GO:0001527; C:microfibril; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0050431; F:transforming growth factor beta binding; IEA:Ensembl.
DR GO; GO:0046879; P:hormone secretion; IEA:Ensembl.
DR GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR CDD; cd00054; EGF_CA; 13.
DR Gene3D; 2.10.25.10; Laminin; 20.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 4.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR24034; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24034:SF46; LATENT-TRANSFORMING GROWTH FACTOR BETA-BINDING PROTEIN 3; 1.
DR Pfam; PF07645; EGF_CA; 17.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF00683; TB; 3.
DR SMART; SM00181; EGF; 20.
DR SMART; SM00179; EGF_CA; 19.
DR SUPFAM; SSF57196; EGF/Laminin; 6.
DR SUPFAM; SSF57184; Growth factor receptor domain; 5.
DR SUPFAM; SSF57581; TB module/8-cys domain; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 13.
DR PROSITE; PS00022; EGF_1; 2.
DR PROSITE; PS01186; EGF_2; 9.
DR PROSITE; PS50026; EGF_3; 13.
DR PROSITE; PS01187; EGF_CA; 8.
DR PROSITE; PS51364; TB; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000028761};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..1617
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5035320132"
FT DOMAIN 149..181
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 287..327
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 357..393
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 407..459
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 583..624
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 625..666
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 667..704
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 706..743
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 748..789
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 830..868
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 874..915
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 916..956
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1045..1086
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1174..1228
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1289..1330
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1342..1395
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1567..1611
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 125..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 474..529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1132..1171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1439..1516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 482..497
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1145..1164
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1439..1455
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 153..163
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 171..180
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 694..703
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1617 AA; 172490 MW; D5C9C28816D7F301 CRC64;
MRRPGTSGRR PLLLVLLLPL FAAAASAASP SPSLSQVVEV AGVPSRQASV AACRCCPGQT
SRRSRCIRAS CRVQNCQPKK CAGPQRCLNP VPAVPSPSPS VRKRQVSLNW QPLTLQEARA
LLKRRRPRGP GGRGLLRRRP PQRAPAGKAP VLCPLICHNG GVCVKPDRCL CPPDFAGKFC
QLHSSGARPP APAIPGLTRS VYTMPLANHR DDEHGVASMV SVHVEHPQEA SVVVHQVERV
SGPWEEADAE AVARAEAAAR AEAAAPYTVL AQSAPREDGY SDASGFGYCF RELRGGECAS
PLPGLRTQEV CCRGAGLAWG VHDCQLCSER LGNSGRLGAP DGPCPTGFER VNGSCEDVDE
CATGGRCQHG ECANTRGGYT CVCPDGFLLD SSRSSCISQH VISEAKGPCF RVLRDGGCSL
PILRNITKQI CCCSRVGKAW GRGCQLCPPF GSEGFREICP AGPGYHYSAS DLRYNTRPLG
QEPPRVSLSQ PRTLPATSRP SAGFLPTHRP ESRPDPRPGP ELPLPSIPAW TGPEIPDSGP
SSGMCQRNPQ VCGPGRCISR PSGYTCACDS GFRLSPQGTR CIDVDECRRV PPPCAPGRCE
NSPGSFRCVC GPGFRAGPRA AECLDVDECH RVPPPCDLGR CENTPGSFLC VCPAGYQAAP
HGASCQDVDE CTQSPGLCGR GACENLPGSF RCVCPAGFRG SACEEDVDEC AQEPPPCGPG
RCDNTAGSFH CACPAGFRSR GPGAPCQDVD ECARSPPPCT YGRCENTEGS FQCVCPTGFQ
PNAAGSECED VDECENHLAC PGQECVNSPG SFQCRPCPPG HHLHRGRCTD VDECSSGAPP
CGPHGHCTNT EGSFRCSCAP GYRAPSGRPG PCADVNECLE GDFCFPHGEC LNTDGSFACT
CAPGYRPGPR GASCLDVDEC SEEDLCQSGI CTNTDGSFEC ICPPGHRAGP DLASCLDVDE
CRERGPALCG SQRCENSPGS YRCVRDCDPG YHAGPEGTCD DVDECQEYGP EICGAQRCEN
TPGSYRCTPA CDPGYQPTPG GGCQDVDECR NRSFCGAHAV CQNLPGSFQC LCDQGYEGAR
DGRHCVDVNE CETLQGVCGA ALCENVEGSF LCVCPNSPEE FDPMTGRCVS PRTSAGTFPG
SQPQAPASPV LPARPPPPRR PSTPRQGPVG SGRRECYFDT AAPDACDNIL ARNVTWQECC
CTVGEGWGNG CRIQQCPGTE TAEYQSLCPH GRGYLAPSGD PSLRRDVDEC QLFRDQVCKS
GVCVNTAPGY SCYCSNGYYY HTQRLECIDN DECADEEPAC EGGRCVNTVG SYHCTCEPPL
VLDGSQRRCV SNESQSLDDN LGVCWQEVGA DLVCSHPRLD RQATYTECCC LYGEAWGMDC
ALCPAQDSDD FEALCNVLRP PAYSPPRPGG FGLPYEYGPD LGPPYQGLPY GPELYPPPAL
PYDPYPPPPG PFARREAPYG APRFDMPDFE DDGGPYGESE APAPPGPGTR WPYRSRDTRR
SFPEPEELPE GGSYAGSLAE PYEELEAEEC GILDGCTNGR CVRVPEGFTC RCFDGYRLDM
TRMACVDINE CDEAEAASPL CVNARCLNTD GSFRCICRQG FAPTHQPHHC APARPRA
//
