ID A0A0A0YTS3_9CAUD Unreviewed; 286 AA.
AC A0A0A0YTS3;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Thymidylate synthase {ECO:0000256|ARBA:ARBA00015931};
DE EC=2.1.1.45 {ECO:0000256|ARBA:ARBA00011947};
GN ORFNames=CPT_Moon252 {ECO:0000313|EMBL:AIX12223.1};
OS Citrobacter phage Moon.
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Straboviridae; Tevenvirinae; Moonvirus; Moonvirus moon.
OX NCBI_TaxID=1540095 {ECO:0000313|EMBL:AIX12223.1, ECO:0000313|Proteomes:UP000030323};
RN [1] {ECO:0000313|EMBL:AIX12223.1, ECO:0000313|Proteomes:UP000030323}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=25635027;
RA Edwards G.B., Luna A.J., Hernandez A.C., Kuty Everett G.F.;
RT "Complete Genome Sequence of Citrobacter freundii Myophage Moon.";
RL Genome Announc. 3:0-0(2015).
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the thymidylate synthase family.
CC {ECO:0000256|ARBA:ARBA00009972}.
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DR EMBL; KM236240; AIX12223.1; -; Genomic_DNA.
DR RefSeq; YP_009146685.1; NC_027331.1.
DR GeneID; 24721851; -.
DR KEGG; vg:24721851; -.
DR Proteomes; UP000030323; Genome.
DR GO; GO:0004799; F:thymidylate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd00351; TS_Pyrimidine_HMase; 1.
DR Gene3D; 3.30.572.10; Thymidylate synthase/dCMP hydroxymethylase domain; 1.
DR HAMAP; MF_00008; Thymidy_synth_bact; 1.
DR InterPro; IPR045097; Thymidate_synth/dCMP_Mease.
DR InterPro; IPR023451; Thymidate_synth/dCMP_Mease_dom.
DR InterPro; IPR036926; Thymidate_synth/dCMP_Mease_sf.
DR InterPro; IPR000398; Thymidylate_synthase.
DR InterPro; IPR020940; Thymidylate_synthase_AS.
DR NCBIfam; TIGR03284; thym_sym; 1.
DR PANTHER; PTHR11548; THYMIDYLATE SYNTHASE 1; 1.
DR PANTHER; PTHR11548:SF1; THYMIDYLATE SYNTHASE-RELATED; 1.
DR Pfam; PF00303; Thymidylat_synt; 1.
DR PRINTS; PR00108; THYMDSNTHASE.
DR SUPFAM; SSF55831; Thymidylate synthase/dCMP hydroxymethylase; 1.
DR PROSITE; PS00091; THYMIDYLATE_SYNTHASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022727};
KW Reference proteome {ECO:0000313|Proteomes:UP000030323};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2..286
FT /note="Thymidylate synthase/dCMP hydroxymethylase"
FT /evidence="ECO:0000259|Pfam:PF00303"
FT ACT_SITE 156
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10016"
SQ SEQUENCE 286 AA; 32906 MW; 23AE971D8FCD6B68 CRC64;
MKQYQELIQH IFDNGYETDD RTGTGTIAVF GTQLRFDLQE GFPAVTTKKL AWNACRSELL
WFLRGSTNVN ELRQIQHGSL IEGNTVWDDN YNNQAIDMGY SGGELGPVYG KQWRDFMGVD
QLMMVIDRIK QMPNDRRQIV TAWNPVDIPK MALPPCHMMY QFNVRNGFLD LQWYQRSVDV
FLGLPFNIAS YAALIHIIAK CTGLKPGHLV FTGGNTHIYM DHISQCKEVL QRDPLELCDM
QINSLPYKFR HLSTAEQIER ITNLRAKDLM LIDYKSHPAI KGKMAI
//
