ID A0A0A1DMJ2_NOCSI Unreviewed; 674 AA.
AC A0A0A1DMJ2;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Succinate dehydrogenase flavoprotein subunit {ECO:0000313|EMBL:AIY16595.1};
GN Name=sdhA {ECO:0000313|EMBL:GEB15405.1};
GN ORFNames=KR76_07120 {ECO:0000313|EMBL:AIY16595.1}, NSI01_37200
GN {ECO:0000313|EMBL:GEB15405.1};
OS Nocardioides simplex (Arthrobacter simplex).
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Pimelobacter.
OX NCBI_TaxID=2045 {ECO:0000313|EMBL:AIY16595.1, ECO:0000313|Proteomes:UP000030300};
RN [1] {ECO:0000313|EMBL:AIY16595.1, ECO:0000313|Proteomes:UP000030300}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM Ac-2033D {ECO:0000313|EMBL:AIY16595.1,
RC ECO:0000313|Proteomes:UP000030300};
RX PubMed=25573942;
RA Shtratnikova V.Y., Schelkunov M.I., Pekov Y.A., Fokina V.V.,
RA Logacheva M.D., Sokolov S.L., Bragin E.Y., Ashapkin V.V., Donova M.V.;
RT "Complete Genome Sequence of Steroid-Transforming Nocardioides simplex VKM
RT Ac-2033D.";
RL Genome Announc. 3:0-0(2015).
RN [2] {ECO:0000313|EMBL:GEB15405.1, ECO:0000313|Proteomes:UP000318936}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 12069 {ECO:0000313|EMBL:GEB15405.1,
RC ECO:0000313|Proteomes:UP000318936};
RA Hosoyama A., Uohara A., Ohji S., Ichikawa N.;
RT "Whole genome shotgun sequence of Pimelobacter simplex NBRC 12069.";
RL Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP009896; AIY16595.1; -; Genomic_DNA.
DR EMBL; BJMC01000017; GEB15405.1; -; Genomic_DNA.
DR RefSeq; WP_038677450.1; NZ_JAAARG010000471.1.
DR AlphaFoldDB; A0A0A1DMJ2; -.
DR STRING; 2045.KR76_07120; -.
DR KEGG; psim:KR76_07120; -.
DR eggNOG; COG1053; Bacteria.
DR HOGENOM; CLU_014312_7_0_11; -.
DR OrthoDB; 9805351at2; -.
DR Proteomes; UP000030300; Chromosome.
DR Proteomes; UP000318936; Unassembled WGS sequence.
DR GO; GO:0033765; F:steroid dehydrogenase activity, acting on the CH-CH group of donors; IEA:UniProt.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 1.20.58.100; Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain; 1.
DR Gene3D; 3.90.700.10; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
DR InterPro; IPR003953; FAD-binding_2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR037099; Fum_R/Succ_DH_flav-like_C_sf.
DR InterPro; IPR015939; Fum_Rdtase/Succ_DH_flav-like_C.
DR InterPro; IPR030664; SdhA/FrdA/AprA.
DR InterPro; IPR011280; Succ_DH/Fum_Rdt_flav_su.
DR InterPro; IPR027477; Succ_DH/fumarate_Rdtase_cat_sf.
DR NCBIfam; TIGR01811; sdhA_Bsu; 1.
DR PANTHER; PTHR11632; SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT; 1.
DR PANTHER; PTHR11632:SF53; SUCCINATE DEHYDROGENASE FLAVOPROTEIN SUBUNIT; 1.
DR Pfam; PF00890; FAD_binding_2; 1.
DR Pfam; PF02910; Succ_DH_flav_C; 1.
DR PRINTS; PR00368; FADPNR.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF46977; Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain; 1.
DR SUPFAM; SSF56425; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
PE 4: Predicted;
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000030300}.
FT DOMAIN 67..478
FT /note="FAD-dependent oxidoreductase 2 FAD binding"
FT /evidence="ECO:0000259|Pfam:PF00890"
FT DOMAIN 539..673
FT /note="Fumarate reductase/succinate dehydrogenase
FT flavoprotein-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02910"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 363
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR630664-50"
SQ SEQUENCE 674 AA; 74959 MW; 2A729B041B8EE764 CRC64;
MAGSTLHDGL TPLNGPSEQK SDDARGYYTL GDKLVDPVAP TGPIKDRWTT RKFENRLVNP
ANRRKLDVII VGTGLAGGAA AATLGEAGYN VKSFCYQDSP RRAHSIAAQG GINAAKNYKE
DGDSTFRLFY DTVKGGDYRS RESNVYRLAE VSANIIDQCV AQGVPFAREY GGLLDNRSFG
GVQVSRTFYA RGQTGQQLLI GAYQAMERQV AAGTVESFTR HEMLELIVVD GKARGIIARD
MVTGEIETHL ADVVVLATGG YGNVFFLSTN AMGSNVTAAW RAHRKGAYMA NPCYTQIHPT
CIPVSGDHQS KLTLMSESLR NDGRIWVPKK KEDCEKDPRD IPEEDRDYYL ERIYPSFGNL
VPRDIASRQA KNMCDEGRGV GPLVGDFRRG VYLDLGDAIK RLGKDAIEEK YDNLLDMYER
ITGENPYEVP MRIYPAVHYV MGGLWVDYHL QSNIPGLFVS GEANFSDHGA NRLGASALMQ
GLADGYFVLP NTIRDYLADG PFEKIDETHE AVVEARRSVE DRVQKFLSIN GTRSADSYHK
ELGNIMWEYC GMERTEDGLR KAIDMIRELK ADFWSNLKVL GSADTLNQSL EKAGRVADFI
ELGELMCIDA LNRRESCGGH FRAESQTDDG EALRHDDEFA YVAAWEWGGD EGQPVLHKED
LIYTAIEMKQ RSYK
//
