ID A0A0A1DNH7_NOCSI Unreviewed; 676 AA.
AC A0A0A1DNH7;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 2.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Putative membrane protein {ECO:0000313|EMBL:AIY18946.2};
GN ORFNames=KR76_23130 {ECO:0000313|EMBL:AIY18946.2};
OS Nocardioides simplex (Arthrobacter simplex).
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Pimelobacter.
OX NCBI_TaxID=2045 {ECO:0000313|EMBL:AIY18946.2, ECO:0000313|Proteomes:UP000030300};
RN [1] {ECO:0000313|EMBL:AIY18946.2, ECO:0000313|Proteomes:UP000030300}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM Ac-2033D {ECO:0000313|EMBL:AIY18946.2,
RC ECO:0000313|Proteomes:UP000030300};
RX PubMed=25573942;
RA Shtratnikova V.Y., Schelkunov M.I., Pekov Y.A., Fokina V.V.,
RA Logacheva M.D., Sokolov S.L., Bragin E.Y., Ashapkin V.V., Donova M.V.;
RT "Complete Genome Sequence of Steroid-Transforming Nocardioides simplex VKM
RT Ac-2033D.";
RL Genome Announc. 3:0-0(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
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DR EMBL; CP009896; AIY18946.2; -; Genomic_DNA.
DR AlphaFoldDB; A0A0A1DNH7; -.
DR STRING; 2045.KR76_23130; -.
DR KEGG; psim:KR76_23130; -.
DR eggNOG; COG2409; Bacteria.
DR HOGENOM; CLU_005108_4_1_11; -.
DR Proteomes; UP000030300; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030300};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..187
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 194..215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 227..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 299..325
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 356..381
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 504..521
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 528..548
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 560..580
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 601..626
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 632..659
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 206..324
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT DOMAIN 531..659
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 676 AA; 70077 MW; ED1F982DF7EEDD6A CRC64;
MSQRLLPFLR PRVAWVLPMI YLVLGGALIG LAGTAPVERA TTDQLPGGYD STEVARLVEA
FPSGRDQVAV VLFSADRALS DGDRAAVARV LERAAGAGAE QVPLQPSADG TALVGVVPVA
ETDATRLADD VDELRAQVRE GLPDGVRAAV TGPAAIQGDL ARVFDGADLR LLLVTASVVA
VLLIITYRSP LLWLVPLTVV GVADRLAAVA ATHALSGLGV AFDESTTGIL SVLVFGAGTD
YALLLISRYR DELRRTPSRA EAMAHAWVRT GEAVLASAAT VVLALLALLL SAFPTTRGLG
LACAIGVVVA AVAVLVVLPL ALVVFPRWIF WPRRPEVGQD AVAEGRTFWR RIGDAVAARP
VTAAVAGLVV LAALASGMLG IRSGLSEADQ FLDTPESITA AARLAESFPA GSTDPAVVLT
SADVPTVVAA AEGADGVESV RKVGEHDGRT RLDVVLAHAP GTADARADVA SLRAALDDLP
DTLVGGVDAE DVDIADATSA DRGLILPLIL VVVLLALGLL LRSVVAPVVL VATVVATYLA
ALGAGWLIGS QVFGFDRLDV GVPLQAFLFL VALGVDYNIF LVTRAAEEGR RHGPREGMLR
ALASTGGVIT SAGVLLAAVF AVLGVLPLVV LAQLGIVICV GVLLDTLLVR TVLVPALAVR
MGDRFWWPRR VVRPGR
//
