ID A0A0A1DNY8_NOCSI Unreviewed; 284 AA.
AC A0A0A1DNY8;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=3-hydroxybutyryl-CoA dehydrogenase {ECO:0000313|EMBL:AIY19121.1};
DE EC=1.1.1.157 {ECO:0000313|EMBL:AIY19121.1};
GN Name=paaH {ECO:0000313|EMBL:GEB14947.1};
GN ORFNames=F9L07_12115 {ECO:0000313|EMBL:KAB2812501.1}, KR76_24330
GN {ECO:0000313|EMBL:AIY19121.1}, NSI01_32620
GN {ECO:0000313|EMBL:GEB14947.1};
OS Nocardioides simplex (Arthrobacter simplex).
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Pimelobacter.
OX NCBI_TaxID=2045 {ECO:0000313|EMBL:AIY19121.1, ECO:0000313|Proteomes:UP000030300};
RN [1] {ECO:0000313|EMBL:AIY19121.1, ECO:0000313|Proteomes:UP000030300}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM Ac-2033D {ECO:0000313|EMBL:AIY19121.1,
RC ECO:0000313|Proteomes:UP000030300};
RX PubMed=25573942;
RA Shtratnikova V.Y., Schelkunov M.I., Pekov Y.A., Fokina V.V.,
RA Logacheva M.D., Sokolov S.L., Bragin E.Y., Ashapkin V.V., Donova M.V.;
RT "Complete Genome Sequence of Steroid-Transforming Nocardioides simplex VKM
RT Ac-2033D.";
RL Genome Announc. 3:0-0(2015).
RN [2] {ECO:0000313|EMBL:GEB14947.1, ECO:0000313|Proteomes:UP000318936}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 12069 {ECO:0000313|EMBL:GEB14947.1,
RC ECO:0000313|Proteomes:UP000318936};
RA Hosoyama A., Uohara A., Ohji S., Ichikawa N.;
RT "Whole genome shotgun sequence of Pimelobacter simplex NBRC 12069.";
RL Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KAB2812501.1, ECO:0000313|Proteomes:UP000449906}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pch-N {ECO:0000313|EMBL:KAB2812501.1,
RC ECO:0000313|Proteomes:UP000449906};
RA Jeong S.E.;
RT "Pimelobacter sp. isolated from Paulinella.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC {ECO:0000256|ARBA:ARBA00005086}.
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DR EMBL; CP009896; AIY19121.1; -; Genomic_DNA.
DR EMBL; BJMC01000015; GEB14947.1; -; Genomic_DNA.
DR EMBL; WBVM01000001; KAB2812501.1; -; Genomic_DNA.
DR RefSeq; WP_038682044.1; NZ_WBVM01000001.1.
DR AlphaFoldDB; A0A0A1DNY8; -.
DR STRING; 2045.KR76_24330; -.
DR KEGG; psim:KR76_24330; -.
DR eggNOG; COG1250; Bacteria.
DR HOGENOM; CLU_009834_2_0_11; -.
DR OrthoDB; 5240528at2; -.
DR Proteomes; UP000030300; Chromosome.
DR Proteomes; UP000318936; Unassembled WGS sequence.
DR Proteomes; UP000449906; Unassembled WGS sequence.
DR GO; GO:0008691; F:3-hydroxybutyryl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR022694; 3-OHacyl-CoA_DH.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR PIRSF; PIRSF000105; HCDH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:AIY19121.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000030300}.
FT DOMAIN 7..184
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 187..283
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT SITE 140
FT /note="Important for catalytic activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR000105-1"
SQ SEQUENCE 284 AA; 30161 MW; 55EE49E54ECECB71 CRC64;
MTGIERVGVV GGGLMGSGIA EVNARAGKDV IVVESSPAAV DNARQRLTSS LERAESRGKI
ESAAAVLDRI RVVDDLTALA DRDIVIEAIV EDEAAKTDLF RRLDEIVTSP DAILASNTSS
IPIMKLAVAT QRPSHVLGVH FFNPVPVLKL VELVPSLMTD AATTERARAF VQDDLGKNAI
DCQDRAGFVV NALLIPFILS AIRMLESGFA TAEDIDQGLV LGAAHPQGPL ALADLIGLDT
TKAVAESLYE EFKEPLYAAP PLLARMVEAG LLGRKTGRGF YTYG
//
