ID   A0A0A1DR91_NOCSI        Unreviewed;       567 AA.
AC   A0A0A1DR91;
DT   04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT   04-FEB-2015, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=AMP-dependent synthetase {ECO:0000313|EMBL:GEB14948.1};
DE   SubName: Full=Acetyl-coenzyme A synthetase {ECO:0000313|EMBL:AIY19122.1};
DE            EC=6.2.1.1 {ECO:0000313|EMBL:AIY19122.1};
GN   ORFNames=KR76_24335 {ECO:0000313|EMBL:AIY19122.1}, NSI01_32630
GN   {ECO:0000313|EMBL:GEB14948.1};
OS   Nocardioides simplex (Arthrobacter simplex).
OC   Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC   Nocardioidaceae; Pimelobacter.
OX   NCBI_TaxID=2045 {ECO:0000313|EMBL:AIY19122.1, ECO:0000313|Proteomes:UP000030300};
RN   [1] {ECO:0000313|EMBL:AIY19122.1, ECO:0000313|Proteomes:UP000030300}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VKM Ac-2033D {ECO:0000313|EMBL:AIY19122.1,
RC   ECO:0000313|Proteomes:UP000030300};
RX   PubMed=25573942;
RA   Shtratnikova V.Y., Schelkunov M.I., Pekov Y.A., Fokina V.V.,
RA   Logacheva M.D., Sokolov S.L., Bragin E.Y., Ashapkin V.V., Donova M.V.;
RT   "Complete Genome Sequence of Steroid-Transforming Nocardioides simplex VKM
RT   Ac-2033D.";
RL   Genome Announc. 3:0-0(2015).
RN   [2] {ECO:0000313|EMBL:GEB14948.1, ECO:0000313|Proteomes:UP000318936}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 12069 {ECO:0000313|EMBL:GEB14948.1,
RC   ECO:0000313|Proteomes:UP000318936};
RA   Hosoyama A., Uohara A., Ohji S., Ichikawa N.;
RT   "Whole genome shotgun sequence of Pimelobacter simplex NBRC 12069.";
RL   Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000256|ARBA:ARBA00006432}.
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DR   EMBL; CP009896; AIY19122.1; -; Genomic_DNA.
DR   EMBL; BJMC01000015; GEB14948.1; -; Genomic_DNA.
DR   RefSeq; WP_038682046.1; NZ_JAAARG010000031.1.
DR   AlphaFoldDB; A0A0A1DR91; -.
DR   STRING; 2045.KR76_24335; -.
DR   KEGG; psim:KR76_24335; -.
DR   eggNOG; COG0365; Bacteria.
DR   HOGENOM; CLU_000022_59_10_11; -.
DR   OrthoDB; 9803968at2; -.
DR   Proteomes; UP000030300; Chromosome.
DR   Proteomes; UP000318936; Unassembled WGS sequence.
DR   GO; GO:0003987; F:acetate-CoA ligase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   PANTHER; PTHR43605:SF10; ACYL-COA SYNTHETASE MEDIUM CHAIN FAMILY MEMBER 3; 1.
DR   PANTHER; PTHR43605; ACYL-COENZYME A SYNTHETASE; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   3: Inferred from homology;
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:AIY19122.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030300}.
FT   DOMAIN          47..393
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   DOMAIN          456..533
FT                   /note="AMP-binding enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13193"
FT   REGION          548..567
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   567 AA;  60899 MW;  F83EA65655C3DA40 CRC64;
     MSTALGTARD LLRTHRTDRA AAVASFRWPD VGPSFNFVHD WFDGYARDND QPALVIVEED
     GARSSYTFGE MVTRSEQVAA YLAAQGVGRG DAVVVMLGNQ VELWESMLAL IRLGAVIMPT
     TTAVGTAELV DRLERGAARA VICNAADVPK FDEVPGAPVR VVVGSSDASG WLPYATAYES
     AAVPVPHPGN ASDDRLLLYF TSGTTSRPKL VEHTHVSYPV GHLSTMYWLG LQAGDVHLNI
     SSPGWAKHAW SNFFAPWLAE ATVFVYNYAR FDAAALLGQI RAEGVTTFCA PPTVWRMLIN
     ADLSGGPGVL REAIAAGEPL NPEVISQVEK HWGLTIRDGF GQTEMTACIA NTPGQPVVPG
     AMGHPLPGMP VVLVDPLTGE VVPGVGEGEL CLDLAAHPLP LMTGYQGDPA KNAEAMAGGF
     YHTGDVASRD ADGCITYVGR TDDVFKASDY KISPFELESV LIEHPAVAEA AVVPAPDPVR
     LAVPKAYIAL VPGHTPSAET AESILKYARE HLAPYLRVRR LEFFELPKTI SGKIRRVELR
     HREVDAEASG QRSAGEFRDD DFPGLRG
//