ID A0A0A1DUJ4_NOCSI Unreviewed; 295 AA.
AC A0A0A1DUJ4;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Lipase {ECO:0000313|EMBL:GEB14870.1};
DE SubName: Full=Putative secreted hydrolase {ECO:0000313|EMBL:AIY19070.1};
GN ORFNames=KR76_23955 {ECO:0000313|EMBL:AIY19070.1}, NSI01_31850
GN {ECO:0000313|EMBL:GEB14870.1};
OS Nocardioides simplex (Arthrobacter simplex).
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Pimelobacter.
OX NCBI_TaxID=2045 {ECO:0000313|EMBL:AIY19070.1, ECO:0000313|Proteomes:UP000030300};
RN [1] {ECO:0000313|EMBL:AIY19070.1, ECO:0000313|Proteomes:UP000030300}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VKM Ac-2033D {ECO:0000313|EMBL:AIY19070.1,
RC ECO:0000313|Proteomes:UP000030300};
RX PubMed=25573942;
RA Shtratnikova V.Y., Schelkunov M.I., Pekov Y.A., Fokina V.V.,
RA Logacheva M.D., Sokolov S.L., Bragin E.Y., Ashapkin V.V., Donova M.V.;
RT "Complete Genome Sequence of Steroid-Transforming Nocardioides simplex VKM
RT Ac-2033D.";
RL Genome Announc. 3:0-0(2015).
RN [2] {ECO:0000313|EMBL:GEB14870.1, ECO:0000313|Proteomes:UP000318936}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 12069 {ECO:0000313|EMBL:GEB14870.1,
RC ECO:0000313|Proteomes:UP000318936};
RA Hosoyama A., Uohara A., Ohji S., Ichikawa N.;
RT "Whole genome shotgun sequence of Pimelobacter simplex NBRC 12069.";
RL Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP009896; AIY19070.1; -; Genomic_DNA.
DR EMBL; BJMC01000015; GEB14870.1; -; Genomic_DNA.
DR RefSeq; WP_038681938.1; NZ_JAAARG010000021.1.
DR AlphaFoldDB; A0A0A1DUJ4; -.
DR STRING; 2045.KR76_23955; -.
DR KEGG; psim:KR76_23955; -.
DR eggNOG; COG2755; Bacteria.
DR HOGENOM; CLU_038449_4_1_11; -.
DR OrthoDB; 5503950at2; -.
DR Proteomes; UP000030300; Chromosome.
DR Proteomes; UP000318936; Unassembled WGS sequence.
DR GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR CDD; cd01823; SEST_like; 1.
DR Gene3D; 3.40.50.1110; SGNH hydrolase; 1.
DR InterPro; IPR037460; SEST-like.
DR InterPro; IPR013830; SGNH_hydro.
DR InterPro; IPR036514; SGNH_hydro_sf.
DR PANTHER; PTHR37981; LIPASE 2; 1.
DR PANTHER; PTHR37981:SF1; SGNH_HYDRO DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13472; Lipase_GDSL_2; 1.
DR SUPFAM; SSF52266; SGNH hydrolase; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR637460-2};
KW Hydrolase {ECO:0000313|EMBL:AIY19070.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000030300};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..295
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5038290507"
FT DOMAIN 45..276
FT /note="SGNH hydrolase-type esterase"
FT /evidence="ECO:0000259|Pfam:PF13472"
FT REGION 92..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 49
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR637460-1"
FT ACT_SITE 275
FT /evidence="ECO:0000256|PIRSR:PIRSR637460-1"
FT DISULFID 65..89
FT /evidence="ECO:0000256|PIRSR:PIRSR637460-2"
FT DISULFID 142..155
FT /evidence="ECO:0000256|PIRSR:PIRSR637460-2"
FT DISULFID 208..256
FT /evidence="ECO:0000256|PIRSR:PIRSR637460-2"
SQ SEQUENCE 295 AA; 30554 MW; 241A218EE6D3AD3E CRC64;
MRPAFRGLLV LVAGSVLLAG CNGGNDPAPT ITPPTGIADG GVYVALGDSY TAGPRLGVTS
GAQGCEQTTG NYPHLLAERL GLELTDVSCG GATSESLTKS QTPPNGTPVP PQLDAVTADA
DLVTLSIGGN DGRAFGTLVT TCVGLALKDR KGAPCAELGK KARDGLGSEV DGLAKRLVAT
VEKIRKRAPD ARIVMVGYPQ MFPASGTCDL LPLAAGDYPF ARDLVERVVQ AQQDAATEAG
IDYVDVWTAS EGHDICSADP WIAGLIPAER ALEYHPYAEE QKVVADLLEE LLSQA
//
