ID A0A0A1H3E1_9BURK Unreviewed; 462 AA.
AC A0A0A1H3E1;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Methyltransferase {ECO:0000256|RuleBase:RU362026};
DE EC=2.1.1.- {ECO:0000256|RuleBase:RU362026};
GN ORFNames=E1O_17320 {ECO:0000313|EMBL:BAP88863.1};
OS Burkholderiales bacterium GJ-E10.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales.
OX NCBI_TaxID=1469502 {ECO:0000313|EMBL:BAP88863.1, ECO:0000313|Proteomes:UP000031649};
RN [1] {ECO:0000313|EMBL:BAP88863.1, ECO:0000313|Proteomes:UP000031649}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GJ-E10 {ECO:0000313|EMBL:BAP88863.1,
RC ECO:0000313|Proteomes:UP000031649};
RA Fukushima J., Tojo F., Asano R., Kobayashi Y., Shimura Y., Okano K.,
RA Miyata N.;
RT "Complete Genome Sequence of the Unclassified Iron-Oxidizing,
RT Chemolithoautotrophic Burkholderiales bacterium GJ-E10 Isolated from Acid
RT River.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-
CC methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:16857, Rhea:RHEA-COMP:11369, Rhea:RHEA-COMP:13674,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:85452, ChEBI:CHEBI:137933; EC=2.1.1.113;
CC Evidence={ECO:0000256|ARBA:ARBA00001893};
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family. N(4)
CC subfamily. {ECO:0000256|ARBA:ARBA00010203}.
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DR EMBL; AP014683; BAP88863.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0A1H3E1; -.
DR STRING; 1469502.E1O_17320; -.
DR REBASE; 97127; M2.Bba10ORF17310P.
DR KEGG; bbag:E1O_17320; -.
DR HOGENOM; CLU_024927_0_0_4; -.
DR OrthoDB; 9816288at2; -.
DR Proteomes; UP000031649; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0015667; F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity; IEA:UniProtKB-EC.
DR CDD; cd16403; ParB_N_like_MT; 1.
DR Gene3D; 3.90.1530.10; Conserved hypothetical protein from pyrococcus furiosus pfu- 392566-001, ParB domain; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002941; DNA_methylase_N4/N6.
DR InterPro; IPR015840; DNA_MeTrfase_ParB.
DR InterPro; IPR017985; MeTrfase_CN4_CS.
DR InterPro; IPR003115; ParB/Sulfiredoxin_dom.
DR InterPro; IPR036086; ParB/Sulfiredoxin_sf.
DR InterPro; IPR001091; RM_Methyltransferase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33375; CHROMOSOME-PARTITIONING PROTEIN PARB-RELATED; 1.
DR PANTHER; PTHR33375:SF1; CHROMOSOME-PARTITIONING PROTEIN PARB-RELATED; 1.
DR Pfam; PF01555; N6_N4_Mtase; 1.
DR Pfam; PF02195; ParBc; 1.
DR PIRSF; PIRSF036758; Aden_M_ParB; 2.
DR PRINTS; PR00508; S21N4MTFRASE.
DR SMART; SM00470; ParB; 1.
DR SUPFAM; SSF110849; ParB/Sulfiredoxin; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00093; N4_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:BAP88863.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000031649};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:BAP88863.1}.
FT DOMAIN 7..93
FT /note="ParB/Sulfiredoxin"
FT /evidence="ECO:0000259|SMART:SM00470"
FT REGION 138..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 313..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 313..335
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 462 AA; 51036 MW; 4128B025D04ABC6A CRC64;
MPELSIDYRP IESLIPFARN ARTHSEEQIA GIAASIREFG FNNPILVDGN RGVIAGHGRI
LAARKLEMTQ LPVIELAHLT ETQKRAFILA ENKLTERAGW DQELLSLEIA DLQAAGFDLD
LTGFDAGEIA SLLAGLDEET DAPSAEPAEE IPETPVQPVS RPGDIWHLGA HRLICGDAAD
PQVIAALMDG EPALLCFTSP PYGNQRDYTQ GIGDWDALMQ GVFAHLPMAS DGQVLVNLGL
IHRDNEVIPY WDGWLSWMRT QGWRRFAWYV WDQGPGMPGD WNGRLAPSFE FIFHFNREAR
RPNKIVPCKH AGEDSHLRAD GSSTAMRKKD GEVGGWSHAG EPTQDTRIPD SVIRIMRHKG
KIGEGIDHPA VFPVALPEHV MEAFSNPDDL VFEPFNGSGS SLLAAERTGR CCRAVEIAPE
YVDVAIRRFR QNHPDVPVTL AATGQSFDEV AIERQMPEAC HD
//
