ID A0A0A1H5W9_9BURK Unreviewed; 805 AA.
AC A0A0A1H5W9;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:BAP89753.1};
GN ORFNames=E1O_26220 {ECO:0000313|EMBL:BAP89753.1};
OS Burkholderiales bacterium GJ-E10.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales.
OX NCBI_TaxID=1469502 {ECO:0000313|EMBL:BAP89753.1, ECO:0000313|Proteomes:UP000031649};
RN [1] {ECO:0000313|EMBL:BAP89753.1, ECO:0000313|Proteomes:UP000031649}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GJ-E10 {ECO:0000313|EMBL:BAP89753.1,
RC ECO:0000313|Proteomes:UP000031649};
RA Fukushima J., Tojo F., Asano R., Kobayashi Y., Shimura Y., Okano K.,
RA Miyata N.;
RT "Complete Genome Sequence of the Unclassified Iron-Oxidizing,
RT Chemolithoautotrophic Burkholderiales bacterium GJ-E10 Isolated from Acid
RT River.";
RL Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
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DR EMBL; AP014683; BAP89753.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0A1H5W9; -.
DR STRING; 1469502.E1O_26220; -.
DR KEGG; bbag:E1O_26220; -.
DR HOGENOM; CLU_010448_0_0_4; -.
DR OrthoDB; 5287258at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000031649; Chromosome.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000031649}.
FT DOMAIN 8..191
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 195..296
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 805 AA; 87173 MW; 6C0A7DE2BC9692A5 CRC64;
MQDVRIRKVA VLGAGVMGAQ IAAHCVNARV PALLFDLPDE QGGDRSATAR RAIEGLPRIS
PAPLGVPEDA QFLAAANYAE DLAALRDCDL VIEAIAERLD WKRALYEKIA PHLAPHAILA
SNTSGLSIAR LSDGLAEDLR ARFCGVHFFN PPRYMHLVEL IPDAATDAQV LDQLETFLTA
VLGKGVVRAR DTPNFVANRI GVFSVLSTMH EAGKAGLPFD VVDDLTGTRI GRAKSATFRT
ADVVGLDTLA HVIGTMRDNL DPADDPFAPH FAVPAVLQTL IDRGALGQKR GAGFFRKDGR
AIRVFDPQRG DYADGGRKAD ELIGRICRKP FAERLALLRE TDHPQARFLW AIFRDVFHYA
ALHLEPIADS AREVDLAMRW GFGWDLGPFE IWQEAGWTRV AEWIRADIDA GEAMSDAPLP
AWVFEGPVAD AQAVHTPEGS WSPAHEAFVV RDDLPIHRRQ LFRPTVVGDG SPSPMASGIT
QHEDESCRIW HLEGGMPAEV LVFSIKTKVH AMGPGVIAGL AKAVALAEAR YRGLVIWSPE
EPFSAGADLQ GMLPAFLHGG PPAIGELQRQ MQEAFLAVKY AQVPVIAAVR GMALGGGCEL
LLHCAKRVAA FESYVGLVEV GVGLVPGAGG LKEGAMRAAA AASAVGSADL LPFLRHWFEN
AATAKVATSA YEARRMGYLL PSDTVVFHPQ ELLWTAIFEA FTLHATGYRP PLRGRRFAAA
GRSALATLKA FAANLREGGF ASEHDFHLAA QIAEVLCGGD LDAGALVDED WFLEQERRHF
VPLLAHPRTQ ERLMGFLQTG KPVRN
//