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Database: UniProt
Entry: A0A0A1H5W9_9BURK
LinkDB: A0A0A1H5W9_9BURK
Original site: A0A0A1H5W9_9BURK 
ID   A0A0A1H5W9_9BURK        Unreviewed;       805 AA.
AC   A0A0A1H5W9;
DT   04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT   04-FEB-2015, sequence version 1.
DT   24-JAN-2024, entry version 39.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:BAP89753.1};
GN   ORFNames=E1O_26220 {ECO:0000313|EMBL:BAP89753.1};
OS   Burkholderiales bacterium GJ-E10.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales.
OX   NCBI_TaxID=1469502 {ECO:0000313|EMBL:BAP89753.1, ECO:0000313|Proteomes:UP000031649};
RN   [1] {ECO:0000313|EMBL:BAP89753.1, ECO:0000313|Proteomes:UP000031649}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GJ-E10 {ECO:0000313|EMBL:BAP89753.1,
RC   ECO:0000313|Proteomes:UP000031649};
RA   Fukushima J., Tojo F., Asano R., Kobayashi Y., Shimura Y., Okano K.,
RA   Miyata N.;
RT   "Complete Genome Sequence of the Unclassified Iron-Oxidizing,
RT   Chemolithoautotrophic Burkholderiales bacterium GJ-E10 Isolated from Acid
RT   River.";
RL   Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC         NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|ARBA:ARBA00023693};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|ARBA:ARBA00005005}.
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DR   EMBL; AP014683; BAP89753.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0A1H5W9; -.
DR   STRING; 1469502.E1O_26220; -.
DR   KEGG; bbag:E1O_26220; -.
DR   HOGENOM; CLU_010448_0_0_4; -.
DR   OrthoDB; 5287258at2; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000031649; Chromosome.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   CDD; cd06558; crotonase-like; 1.
DR   Gene3D; 1.10.1040.50; -; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031649}.
FT   DOMAIN          8..191
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          195..296
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
SQ   SEQUENCE   805 AA;  87173 MW;  6C0A7DE2BC9692A5 CRC64;
     MQDVRIRKVA VLGAGVMGAQ IAAHCVNARV PALLFDLPDE QGGDRSATAR RAIEGLPRIS
     PAPLGVPEDA QFLAAANYAE DLAALRDCDL VIEAIAERLD WKRALYEKIA PHLAPHAILA
     SNTSGLSIAR LSDGLAEDLR ARFCGVHFFN PPRYMHLVEL IPDAATDAQV LDQLETFLTA
     VLGKGVVRAR DTPNFVANRI GVFSVLSTMH EAGKAGLPFD VVDDLTGTRI GRAKSATFRT
     ADVVGLDTLA HVIGTMRDNL DPADDPFAPH FAVPAVLQTL IDRGALGQKR GAGFFRKDGR
     AIRVFDPQRG DYADGGRKAD ELIGRICRKP FAERLALLRE TDHPQARFLW AIFRDVFHYA
     ALHLEPIADS AREVDLAMRW GFGWDLGPFE IWQEAGWTRV AEWIRADIDA GEAMSDAPLP
     AWVFEGPVAD AQAVHTPEGS WSPAHEAFVV RDDLPIHRRQ LFRPTVVGDG SPSPMASGIT
     QHEDESCRIW HLEGGMPAEV LVFSIKTKVH AMGPGVIAGL AKAVALAEAR YRGLVIWSPE
     EPFSAGADLQ GMLPAFLHGG PPAIGELQRQ MQEAFLAVKY AQVPVIAAVR GMALGGGCEL
     LLHCAKRVAA FESYVGLVEV GVGLVPGAGG LKEGAMRAAA AASAVGSADL LPFLRHWFEN
     AATAKVATSA YEARRMGYLL PSDTVVFHPQ ELLWTAIFEA FTLHATGYRP PLRGRRFAAA
     GRSALATLKA FAANLREGGF ASEHDFHLAA QIAEVLCGGD LDAGALVDED WFLEQERRHF
     VPLLAHPRTQ ERLMGFLQTG KPVRN
//
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