ID A0A0A1SW60_9HYPO Unreviewed; 1064 AA.
AC A0A0A1SW60;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 08-NOV-2023, entry version 37.
DE RecName: Full=Transcription elongation factor SPT5 {ECO:0000256|ARBA:ARBA00020181, ECO:0000256|PIRNR:PIRNR036945};
GN ORFNames=VHEMI04762 {ECO:0000313|EMBL:CEJ88593.1};
OS [Torrubiella] hemipterigena.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae;
OC Clavicipitaceae incertae sedis; 'Torrubiella' clade.
OX NCBI_TaxID=1531966 {ECO:0000313|EMBL:CEJ88593.1, ECO:0000313|Proteomes:UP000039046};
RN [1] {ECO:0000313|EMBL:CEJ88593.1, ECO:0000313|Proteomes:UP000039046}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Horn F., Habel A., Scharf D.H., Dworschak J., Brakhage A.A., Guthke R.,
RA Hertweck C., Linde J.;
RT "Draft Genome Sequence and Gene Annotation of the Entomopathogenic Fungus
RT Verticillium hemipterigenum.";
RL Genome Announc. 3:e01439-e01414(2015).
CC -!- FUNCTION: The SPT4-SPT5 complex mediates both activation and inhibition
CC of transcription elongation, and plays a role in pre-mRNA processing.
CC This complex seems to be important for the stability of the RNA
CC polymerase II elongation machinery on the chromatin template but not
CC for the inherent ability of this machinery to translocate down the
CC gene. {ECO:0000256|ARBA:ARBA00024691, ECO:0000256|PIRNR:PIRNR036945}.
CC -!- SUBUNIT: Component of the SPT4-SPT5 complex. Interacts with RNA
CC polymerase II. {ECO:0000256|ARBA:ARBA00025870}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR036945}.
CC -!- SIMILARITY: Belongs to the SPT5 family. {ECO:0000256|ARBA:ARBA00006956,
CC ECO:0000256|PIRNR:PIRNR036945}.
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DR EMBL; CDHN01000002; CEJ88593.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0A1SW60; -.
DR STRING; 1531966.A0A0A1SW60; -.
DR HOGENOM; CLU_003537_1_1_1; -.
DR OrthoDB; 24955at2759; -.
DR Proteomes; UP000039046; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0006354; P:DNA-templated transcription elongation; IEA:InterPro.
DR GO; GO:0032784; P:regulation of DNA-templated transcription elongation; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd06081; KOW_Spt5_1; 1.
DR CDD; cd06082; KOW_Spt5_2; 1.
DR CDD; cd06083; KOW_Spt5_3; 1.
DR CDD; cd06084; KOW_Spt5_4; 1.
DR CDD; cd06085; KOW_Spt5_5; 1.
DR CDD; cd09888; NGN_Euk; 1.
DR Gene3D; 2.30.30.30; -; 3.
DR Gene3D; 3.30.70.940; NusG, N-terminal domain; 1.
DR InterPro; IPR005824; KOW.
DR InterPro; IPR041973; KOW_Spt5_1.
DR InterPro; IPR041975; KOW_Spt5_2.
DR InterPro; IPR041976; KOW_Spt5_3.
DR InterPro; IPR041977; KOW_Spt5_4.
DR InterPro; IPR041978; KOW_Spt5_5.
DR InterPro; IPR005100; NGN-domain.
DR InterPro; IPR036735; NGN_dom_sf.
DR InterPro; IPR039385; NGN_Euk.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR InterPro; IPR039659; SPT5.
DR InterPro; IPR024945; Spt5_C_dom.
DR InterPro; IPR022581; Spt5_N.
DR InterPro; IPR017071; TF_Spt5_eukaryote.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR PANTHER; PTHR11125; SUPPRESSOR OF TY 5; 1.
DR PANTHER; PTHR11125:SF7; TRANSCRIPTION ELONGATION FACTOR SPT5; 1.
DR Pfam; PF12815; CTD; 1.
DR Pfam; PF03439; Spt5-NGN; 1.
DR Pfam; PF11942; Spt5_N; 1.
DR PIRSF; PIRSF036945; Spt5; 2.
DR SMART; SM01104; CTD; 1.
DR SMART; SM00739; KOW; 3.
DR SUPFAM; SSF50104; Translation proteins SH3-like domain; 1.
PE 3: Inferred from homology;
KW Elongation factor {ECO:0000313|EMBL:CEJ88593.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR036945};
KW Protein biosynthesis {ECO:0000313|EMBL:CEJ88593.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000039046};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR036945}.
FT DOMAIN 478..505
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 531..559
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 749..776
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 859..1031
FT /note="Spt5 C-terminal"
FT /evidence="ECO:0000259|SMART:SM01104"
FT REGION 1..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 368..390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 806..1064
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..23
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..55
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..107
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..160
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..182
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 875..908
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 938..962
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1064 AA; 114631 MW; DCBD1B159669011F CRC64;
MASSDPNRFD DSEEDDDFNP APADMSDDEP SSRRQRDDDN EDNSSPVRSR RVADDGSDDE
DEDEGPSEKR RRRNDDDEDE DEDEEEGGRK GNEDDDDEEE EEEEEEDDVN QGHRRKRRRD
RRNAFLDIEA EVDDEDEDGD EEKDGEEIGD FIENDDADDI AVGGGDERRH RELDRRREME
SNLDAEKQAE LLRAKYGNRR SGKGFGESAV IPKRLLLPSV DDPGIWAVRC KEGKEREVVL
SIMKRIDERM GTKDELAITA AFERGGTNSV MKGFIYVEAQ RQTDILVSLD GILNVYPRTK
MTLVDIKDMP ELLRVTKTPM LEPGAWVRLR RPLKHSGDLA QVLDVTENGL EARVRFVPRI
DYGMRDDGLG VSADGKRKRP AGPGPRPPQR LFSEIEARKH NPRYIQGNPT TNTWSFMGDE
FENGFQVRDV KIQQLVVTDV NPTLEEVTRF ASGAEDGTEN LDLKALAASL KDSNTNVAYL
PGDIIEVYQG EQKGVIGRAT NVQGDIVTMT VTEGDLTGQT IEVPTKGLRK RFKVGDHVKV
VGGSRFQDEV GTVVKISEDR VTILTDHTNN EVTVFSKDLR EASDIGGQGS LGQFELQDLV
QLDPTTVGCV VKVDRESLVV LDQFGDARQV MPSQIANKLP KRKQAVAADR NGSEIRIDDV
VKEFTGLERQ GKIIHIHRSY VYLHTHDTNE NAGVFVTKAS MVNTIAAKGG RVNAAASGPD
LDSMNPALKI HKNGSENKAP TPVKLFGRDK AINQTVIVKK GAYKGLLGIV KDTTDTHARV
ELHTKSKTIT VPRECLSFKD KTTGATIDIN GRGRGGPPGA GRGGDRVPSW QGGSRTPMGA
GGGDRVPAWG SRTPAGGAGG RTPAWRAQDV SGSRTPAWAD GSRTVNPYDG SRTAYGSGSR
TPAWQSGART PAQGDAFGAG SRTPAWGAGG DSWGSGSKTP AWGASSAPTP GASGNDSWGY
TPGASASHPY DAPTPGGALG APTPGAFNAP TPGGDFSAPT PAVSAPTPGA GWQGGWGADS
APTPAAGAPT PGASYGGSGY YGAPTPAAPP ETPGASGPRY TDDD
//
