ID   A0A0A1T6W8_9HYPO        Unreviewed;      1023 AA.
AC   A0A0A1T6W8;
DT   04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT   04-FEB-2015, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=Putative Regulator-nonsense transcripts 1 {ECO:0000313|EMBL:CEJ81900.1};
GN   ORFNames=VHEMI02001 {ECO:0000313|EMBL:CEJ81900.1};
OS   [Torrubiella] hemipterigena.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Clavicipitaceae;
OC   Clavicipitaceae incertae sedis; 'Torrubiella' clade.
OX   NCBI_TaxID=1531966 {ECO:0000313|EMBL:CEJ81900.1, ECO:0000313|Proteomes:UP000039046};
RN   [1] {ECO:0000313|EMBL:CEJ81900.1, ECO:0000313|Proteomes:UP000039046}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Horn F., Habel A., Scharf D.H., Dworschak J., Brakhage A.A., Guthke R.,
RA   Hertweck C., Linde J.;
RT   "Draft Genome Sequence and Gene Annotation of the Entomopathogenic Fungus
RT   Verticillium hemipterigenum.";
RL   Genome Announc. 3:e01439-e01414(2015).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family.
CC       {ECO:0000256|ARBA:ARBA00007913}.
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DR   EMBL; CDHN01000001; CEJ81900.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0A1T6W8; -.
DR   OrthoDB; 170190at2759; -.
DR   Proteomes; UP000039046; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:InterPro.
DR   CDD; cd21407; 1B_UPF1-like; 1.
DR   CDD; cd18039; DEXXQc_UPF1; 1.
DR   CDD; cd18808; SF1_C_Upf1; 1.
DR   CDD; cd21400; ZBD_UPF1-like; 1.
DR   Gene3D; 2.40.30.230; -; 1.
DR   Gene3D; 6.10.140.1240; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR045055; DNA2/NAM7-like.
DR   InterPro; IPR041679; DNA2/NAM7-like_C.
DR   InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR047187; SF1_C_Upf1.
DR   InterPro; IPR040812; UPF1_1B_dom.
DR   InterPro; IPR018999; UPF1_CH/ZBD.
DR   PANTHER; PTHR10887; DNA2/NAM7 HELICASE FAMILY; 1.
DR   PANTHER; PTHR10887:SF364; REGULATOR OF NONSENSE TRANSCRIPTS 1; 1.
DR   Pfam; PF13086; AAA_11; 1.
DR   Pfam; PF13087; AAA_12; 1.
DR   Pfam; PF18141; UPF1_1B_dom; 1.
DR   Pfam; PF09416; UPF1_Zn_bind; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51997; UPF1_CH_RICH; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW   ProRule:PRU01341}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000039046};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU01341};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU01341}.
FT   DOMAIN          85..242
FT                   /note="Upf1"
FT                   /evidence="ECO:0000259|PROSITE:PS51997"
FT   REGION          40..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          93..125
FT                   /note="C3H"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT   REGION          107..135
FT                   /note="CC/SHH/C"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT   REGION          153..183
FT                   /note="C4"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01341"
FT   REGION          833..867
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          915..935
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        837..866
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1023 AA;  112988 MW;  9132C421F7CD54E5 CRC64;
     MEGAFTHVGN HLISDSAAAI NADGDDFSAL DPDESLLYGK YGGRSGRRRA DDDDNQTEAF
     DDDDIDSLNS VPVDELMGME LKDREKELPA HACVYCGIHS PACVVKCLTC NKWFCSARGN
     GTSSHIVNHL VRARHREVQL HPESALGDTT LECYSCGTKN CFLLGFIPAK SDTVVVLLCR
     QPCAAASSNK DMNWDVSRWE PLIEERAFLS WLVSAPSEAE QLRARHMTTA TMGKLEALWK
     TDPNATVADL EKTATADEYI ERAPLKFDDP YHYQNIYGPL VKMESDYDKK LKEAQSEDDI
     SVEWGEANNG NITVSFKLRT IDSGEVKLAV GDEMALRYDG GLRDPWRGVG YVTKIPGNDG
     DFVQIELRKT GNDKSVPVEI LNNFSADYIW KATSYDRMQS AMKNFAVDEM SVSGFIFHTL
     LGHDVRLQPM KLNFPKKWSA PGLPDLNQSQ VDAIRSVLQK PLSLIQGPPG TGKTVTSATI
     IYHLAKMSGN PVLVCAPSNV AVDQLCERIH KTGLKVVRLT AKSREDVESS VSFLALHEQV
     RMSEHSSEFT KLSQLKNELG GLSSQDEKKF RHLTKVAERE ILSNADVVCC TCVGAGDPRL
     AKMKFRNLQN HPIVLNIQYR MHPCLSEFPS NMFYDGSLQN GVTHENRLRR DVDFPWPVAE
     MPMLFWSNLG NEEISTSGTS YLNRTEASNV EKIITRFSKA NVKASDIGVI TPYEGQRSYI
     VSTMQNSGTS KKEYYKDVEV ASVDAFQGRE KDFIVLSCVR SNDNQGIGFL SDERRLNVAL
     TRAKYGLVIL GNPKVLAKNP LWYDLLQHFK RNNCFVEGPL TNLQRCLLEF PKPRNTHRNR
     NGQQSQYGNR GGFQSSRFNG GSRETEQGTM RYIPDDVSSI HESQFGGTGL GGAFPPMFST
     FAPEQWPGLP GVGAHGRGGN RRARPAESVA GESVANSEYT DATSSILGGK GVGQGGVSLG
     AGLQDLADGM RPISRTQADR LHEYVESGNR MGPVGAGYVG RRLDDDEKSV NTAFHSQVGG
     GYV
//