ID   A0A0A1TGL3_9HYPO        Unreviewed;       822 AA.
AC   A0A0A1TGL3;
DT   04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT   04-FEB-2015, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE            EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN   ORFNames=VHEMI05271 {ECO:0000313|EMBL:CEJ89428.1};
OS   [Torrubiella] hemipterigena.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Clavicipitaceae;
OC   Clavicipitaceae incertae sedis; 'Torrubiella' clade.
OX   NCBI_TaxID=1531966 {ECO:0000313|EMBL:CEJ89428.1, ECO:0000313|Proteomes:UP000039046};
RN   [1] {ECO:0000313|EMBL:CEJ89428.1, ECO:0000313|Proteomes:UP000039046}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Horn F., Habel A., Scharf D.H., Dworschak J., Brakhage A.A., Guthke R.,
RA   Hertweck C., Linde J.;
RT   "Draft Genome Sequence and Gene Annotation of the Entomopathogenic Fungus
RT   Verticillium hemipterigenum.";
RL   Genome Announc. 3:e01439-e01414(2015).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000256|ARBA:ARBA00001665};
CC   -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC       {ECO:0000256|ARBA:ARBA00006637}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CDHN01000002; CEJ89428.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0A1TGL3; -.
DR   STRING; 1531966.A0A0A1TGL3; -.
DR   HOGENOM; CLU_008213_0_0_1; -.
DR   OrthoDB; 1360679at2759; -.
DR   Proteomes; UP000039046; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR   GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IEA:InterPro.
DR   CDD; cd18029; DEXHc_XPB; 1.
DR   CDD; cd18789; SF2_C_XPB; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR032438; ERCC3_RAD25_C.
DR   InterPro; IPR006935; Helicase/UvrB_N.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001161; XPB/Ssl2.
DR   InterPro; IPR032830; XPB/Ssl2_N.
DR   NCBIfam; TIGR00603; rad25; 1.
DR   PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR   PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR   Pfam; PF16203; ERCC3_RAD25_C; 1.
DR   Pfam; PF13625; Helicase_C_3; 1.
DR   Pfam; PF04851; ResIII; 1.
DR   PRINTS; PR00851; XRODRMPGMNTB.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:CEJ89428.1};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:CEJ89428.1};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022806,
KW   ECO:0000313|EMBL:CEJ89428.1}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000039046}.
FT   DOMAIN          345..508
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          562..716
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   REGION          1..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          744..822
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        792..822
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   822 AA;  92221 MW;  4C0DD4C7C01F9D8C CRC64;
     MPVKRKASGG VAGGAKAGRS SRVSTPGAAT PREIDSDDEY EEGEEEAVVD EVLERDIDKN
     IDQFSLDRYQ RHHDVKEPLP HIFGNNDFSY LDLKKDHQNR PLWIDPQKGR IILESFNPLA
     EQAQDFLITI AEPLSRPTFM HEYALTTHSL YAAVSVGLSP ADIINTLERF LKTPLPSEIR
     SFINGCTQSY GKVKLVLKNT KYYVESPDPD MLQTLLKNPK IGPLRVHGSE EIVTSAAPKI
     GGLVIPGTKS AAGVKQANGQ DGQGIQERDV MAALNDDDDD DQDVTHAFEI ADKDVETVQR
     ECLNLGFPVL EEYDFRRDEA NANLDIDLRP GTQIRPYQEK SLSKMFGNGR AKSGLIVLPC
     GAGKTLVGIT AACTIKKGVI VLCTSSMSVV QWRNEFLKWS NINPDDIVAF TSDSKGSVFT
     GSTGIIVTTY SMVTQSRARS YDAEKMMRFL TGREWGLMLL DEVHVVPANI FRKVTSSIKT
     HSKLGLTATL LREDDKISDL NFLIGPKLFE ANWMELSKQG HIARVQCAEV WCPMPTEFYD
     EYLRAPSRKK NLLYIMNPRK FQACQYLINY HEARGDKIIV FSDNVYALKA YALKLGKAFI
     YGSTGQAERL QVLENFQHNP NVNTLFLSKI GDTSLDLPEA TCLIQISSHY GSRRQEAQRL
     GRILRAKRRN DEGFNAFFYS LVSKDTQEMY FSSKRQAFLV DQGYAFKVIT QLANIEKTPG
     LAFATASERR ELLQKVLVEN ETMDDEDPTD DLFHSGTMGR TKKRGARRTA GTLGELSGGQ
     DMAYIEQNKK LNQSLKKGKG KQDQHKFFKK LRRENARRTA GE
//