ID   A0A0A1TLE0_9HYPO        Unreviewed;       878 AA.
AC   A0A0A1TLE0;
DT   04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT   04-FEB-2015, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   RecName: Full=Peptidase S8/S53 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=VHEMI07447 {ECO:0000313|EMBL:CEJ91755.1};
OS   [Torrubiella] hemipterigena.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Clavicipitaceae;
OC   Clavicipitaceae incertae sedis; 'Torrubiella' clade.
OX   NCBI_TaxID=1531966 {ECO:0000313|EMBL:CEJ91755.1, ECO:0000313|Proteomes:UP000039046};
RN   [1] {ECO:0000313|EMBL:CEJ91755.1, ECO:0000313|Proteomes:UP000039046}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Horn F., Habel A., Scharf D.H., Dworschak J., Brakhage A.A., Guthke R.,
RA   Hertweck C., Linde J.;
RT   "Draft Genome Sequence and Gene Annotation of the Entomopathogenic Fungus
RT   Verticillium hemipterigenum.";
RL   Genome Announc. 3:e01439-e01414(2015).
CC   -!- SIMILARITY: Belongs to the peptidase S8 family.
CC       {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240,
CC       ECO:0000256|RuleBase:RU003355}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CDHN01000004; CEJ91755.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0A1TLE0; -.
DR   STRING; 1531966.A0A0A1TLE0; -.
DR   HOGENOM; CLU_003559_3_1_1; -.
DR   OrthoDB; 662485at2759; -.
DR   Proteomes; UP000039046; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd02124; PA_PoS1_like; 1.
DR   CDD; cd07489; Peptidases_S8_5; 1.
DR   Gene3D; 3.50.30.30; -; 1.
DR   Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR   InterPro; IPR010435; Fn3_5.
DR   InterPro; IPR046450; PA_dom_sf.
DR   InterPro; IPR003137; PA_domain.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR   InterPro; IPR022398; Peptidase_S8_His-AS.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   InterPro; IPR034187; Peptidases_S8_5.
DR   PANTHER; PTHR43806:SF59; CEREVISIN-RELATED; 1.
DR   PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR   Pfam; PF06280; fn3_5; 1.
DR   Pfam; PF02225; PA; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SUPFAM; SSF52025; PA domain; 1.
DR   SUPFAM; SSF52743; Subtilisin-like; 1.
DR   PROSITE; PS51892; SUBTILASE; 1.
DR   PROSITE; PS00136; SUBTILASE_ASP; 1.
DR   PROSITE; PS00137; SUBTILASE_HIS; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU01240};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000039046};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..878
FT                   /note="Peptidase S8/S53 domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5001990138"
FT   DOMAIN          148..563
FT                   /note="Peptidase S8/S53"
FT                   /evidence="ECO:0000259|Pfam:PF00082"
FT   DOMAIN          372..445
FT                   /note="PA"
FT                   /evidence="ECO:0000259|Pfam:PF02225"
FT   DOMAIN          608..719
FT                   /note="Fn3-like"
FT                   /evidence="ECO:0000259|Pfam:PF06280"
FT   ACT_SITE        156
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        205
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        530
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU01240"
SQ   SEQUENCE   878 AA;  93077 MW;  308E157D3951B723 CRC64;
     MVRCGSLFSL LAAASVATVA SATSQVVPGA FLLELEDGHD ATALKQAIKD DGDVRVELDY
     KLFKGASVQF NDLKSAPEAA DKIASLPSVK SVWPVRVYGL PVIEGQQAGK SSPVNLGGLS
     ARDDKDTYST HVQTQIDKMH NMGIKGTKDT KVAILDTGID YKHPALGGCF GPGCLVGFGT
     DLVGDDYTGF NTPQPDADPM DCGGHGSHVA GIIAAQPNEY GVLGAAPNVT MGIYRVFGCS
     GLVSNDVLLS AMNKAFEDGA TIISASIVVA NGWSEDPLAV VASRISEAGV PVLYSQGNDG
     DHGLFYNSNS ADGKSVIAVA AFDNSLYPGF EFESKYAIDG GDKQPFRFVF GLENAWDLTL
     PLWATSLDST IANDACNPLP DNTPDLSNNI VLVRRGGCLF VDKFTNLAKK GARYVLFYQN
     AEAPIFAPTF APEPTQLKAA GMIPAAAGVT LVSALKSGKK VTMYMEGPAT AKSYTYSTPN
     NITAGALSSF TSWGPNWEMD MKPQYGAIGG NVLSTIPRSQ GSYGVKSGTS MSCPQAAGML
     ALLRQVRGPM DIESINNLFA ATSKPQLFND NTKFYDKLAS VAQQGAGLMQ IYDAAFTKTL
     LQPSGLVFND TKHYTPSLNF TISNTGDSSV SYKIGNVPAM TFYTLGADGV SPMMFPNDAV
     NSYASVKFSQ DSLTLEAGHR AVLSVSATPP VGIDLKRLAL WSGFVTVNGT DGSALSIPYQ
     GLSGSLQEHA VILSGQSWIS NSTDAKFNPV AENTTFILPP PGTADANAVL PQITFNLNLG
     SPYLRVDLTP MTTCPPKNLT TQYKDIKTIG QPFGTPYSYL PRGISSVVWD GKLKDNGAYA
     PAGKYKAAIR ALRIFGNPDN DADWDVVSTP RFVIKYKK
//