ID   A0A0A1TPM1_9HYPO        Unreviewed;       614 AA.
AC   A0A0A1TPM1;
DT   04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT   04-FEB-2015, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   RecName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=VHEMI09062 {ECO:0000313|EMBL:CEJ93478.1};
OS   [Torrubiella] hemipterigena.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Clavicipitaceae;
OC   Clavicipitaceae incertae sedis; 'Torrubiella' clade.
OX   NCBI_TaxID=1531966 {ECO:0000313|EMBL:CEJ93478.1, ECO:0000313|Proteomes:UP000039046};
RN   [1] {ECO:0000313|EMBL:CEJ93478.1, ECO:0000313|Proteomes:UP000039046}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Horn F., Habel A., Scharf D.H., Dworschak J., Brakhage A.A., Guthke R.,
RA   Hertweck C., Linde J.;
RT   "Draft Genome Sequence and Gene Annotation of the Entomopathogenic Fungus
RT   Verticillium hemipterigenum.";
RL   Genome Announc. 3:e01439-e01414(2015).
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DR   EMBL; CDHN01000005; CEJ93478.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0A1TPM1; -.
DR   STRING; 1531966.A0A0A1TPM1; -.
DR   HOGENOM; CLU_031652_0_0_1; -.
DR   OrthoDB; 4517707at2759; -.
DR   Proteomes; UP000039046; Unassembled WGS sequence.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR000033; LDLR_classB_rpt.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48075:SF3; 3-HYDROXYACYL-COA DEHYDROGENASE; 1.
DR   PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   SMART; SM00135; LY; 5.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   SUPFAM; SSF101898; NHL repeat; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000039046}.
FT   DOMAIN          12..169
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          187..280
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
SQ   SEQUENCE   614 AA;  68019 MW;  EEB7FF3663338E07 CRC64;
     MTFQLPATTN RTVAVLGGGV LGRRIACSWA ASGFDVAVFD PDSEQRIATV HYCQANAVQF
     SDVKQRGSVE AFQDVQDAVS RAWLVIEAIP ERLALKISTF QQLEVMAPKD AILATNSSSF
     KSREMVSDLQ PSTKQRVLNM HYYMPPRNRV VELMTDGNTD KTIFPFLQRK LGETGMRAYV
     ARKESTGLIF NRLWAAIKRE ILTILAEGVS VPEEIDELWQ QIWVENVSGP VAMMDAVGLD
     TVSFIEQHYI AERQLSDLPV RYLQQYIDEG KLGAKSSKGG LLPAGKTTKT SAKLRGDHDN
     LHAPLLYFLD IGLRAPDIQD AFSSGRILTG ASDGRAMRVL VDHQRTPDGL AVSLAVGKLF
     WTSMGVPAEN DGAVLSANLD GSDVQEIVPR GHVHTPKQIC IDHESKTLYF CDREGLRVMR
     CGFDGSGLET IIRTGRWKED VDAVEDQTNW CVGIAVDLAQ RNFYWTQKGP SKGNMGRILR
     ASLDMPAGQT CDSRSDIEVL FRGLPEPVDL ELDPAERVLY WTDRGEHPVG NSINSASLSG
     IQPVRAENSV PGVHYKILAR NFHEAIGIKL DTRNRHIYAT DLGGSVYRFD LNGGDRQRFY
     EEQGAFTGLT LAFV
//