ID A0A0A1TRZ2_9HYPO Unreviewed; 705 AA.
AC A0A0A1TRZ2;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=ELMO domain-containing protein {ECO:0000259|PROSITE:PS51335};
GN ORFNames=VHEMI10508 {ECO:0000313|EMBL:CEJ95005.1};
OS [Torrubiella] hemipterigena.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae;
OC Clavicipitaceae incertae sedis; 'Torrubiella' clade.
OX NCBI_TaxID=1531966 {ECO:0000313|EMBL:CEJ95005.1, ECO:0000313|Proteomes:UP000039046};
RN [1] {ECO:0000313|EMBL:CEJ95005.1, ECO:0000313|Proteomes:UP000039046}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Horn F., Habel A., Scharf D.H., Dworschak J., Brakhage A.A., Guthke R.,
RA Hertweck C., Linde J.;
RT "Draft Genome Sequence and Gene Annotation of the Entomopathogenic Fungus
RT Verticillium hemipterigenum.";
RL Genome Announc. 3:e01439-e01414(2015).
CC -!- FUNCTION: Involved in cytoskeletal rearrangements required for
CC phagocytosis of apoptotic cells and cell motility. Acts in association
CC with DOCK1 and CRK. Was initially proposed to be required in complex
CC with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine
CC nucleotide exchange factor (GEF) activity of DOCK1.
CC {ECO:0000256|ARBA:ARBA00024863}.
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DR EMBL; CDHN01000008; CEJ95005.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0A1TRZ2; -.
DR STRING; 1531966.A0A0A1TRZ2; -.
DR HOGENOM; CLU_009191_0_0_1; -.
DR OrthoDB; 1473500at2759; -.
DR Proteomes; UP000039046; Unassembled WGS sequence.
DR GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024574; ELMO_ARM.
DR InterPro; IPR006816; ELMO_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR12771:SF56; CED-12; 1.
DR PANTHER; PTHR12771; ENGULFMENT AND CELL MOTILITY; 1.
DR Pfam; PF11841; ELMO_ARM; 1.
DR Pfam; PF04727; ELMO_CED12; 1.
DR Pfam; PF16457; PH_12; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS51335; ELMO; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Phagocytosis {ECO:0000256|ARBA:ARBA00022907};
KW Reference proteome {ECO:0000313|Proteomes:UP000039046};
KW SH3-binding {ECO:0000256|ARBA:ARBA00023036}.
FT DOMAIN 247..435
FT /note="ELMO"
FT /evidence="ECO:0000259|PROSITE:PS51335"
FT REGION 250..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 705 AA; 78835 MW; 749107245798AF55 CRC64;
MDQADIPALL ARLSSDEDAA RKMAVFKLQT SINDPSFADV FISSGGLVIL RRLIMESSGN
TLAYSLQSLT RLLEVDMGWD VFEGPTASDL VERIVQLIVT NPLVNILRGA MSILVALVGH
SQSPQGDASP TTPGSFGFRA LKPAVAVYPQ FFELVVRELS SADHSLCANA LMLVNALIRD
ALSNPSGDEW SKLIKRLQEL GIVKAVYKLM QSSALQDFAH PVLEFQTLSK LLLKRWRDIP
VDVDHPEHRR SLKSLHLASA PERKESEPER DDPGSPDKKS PDKKSPKKHN PEKWRRLGFT
SESPAHDFEI SGCLGMMDLS DYVKKNEDGY QKLLLEQASR PPLERCPIAR ASMTVTLVLC
DHFEIDKADL EEAKGYHDLD PSRYDIIFQP FLLQWSRLHV AGLQAFFRLW KATGAQVGDF
TKVAELLRIL VEEVVGQATR TKDVSEIEED MQEYDVARLR EVQMELLEMA FDDTWNEHLH
QAREVQKQEA IQFVKEQRVR CLLQGSWFTR PTENGVGSKQ EASVWRFAKL SSNRRYLHYA
DFGSKITPDP GLNTLKERID LSTISSVMSN VSANSDAAST RSDSTVQNVA NNNSSSKGST
KITIYSYVDA TEVGRPGGDG AEYPILTLWP TTHSLASEWL DGLLMLLNQT PITAETKKLV
QLVDYYGLKI RLLNVRMDTA LKGPPEGAGV VPSREGLDED YFFEI
//
