ID A0A0A1TVL8_ENTIV Unreviewed; 472 AA.
AC A0A0A1TVL8;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Cysteine protease, putative {ECO:0000313|EMBL:ELP84441.1};
DE Flags: Fragment;
GN ORFNames=EIN_167460 {ECO:0000313|EMBL:ELP84441.1};
OS Entamoeba invadens IP1.
OC Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC Entamoeba.
OX NCBI_TaxID=370355 {ECO:0000313|EMBL:ELP84441.1, ECO:0000313|Proteomes:UP000014680};
RN [1] {ECO:0000313|EMBL:ELP84441.1, ECO:0000313|Proteomes:UP000014680}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IP1 {ECO:0000313|EMBL:ELP84441.1,
RC ECO:0000313|Proteomes:UP000014680};
RA Zafar N., Inman J., Hall N., Lorenzi H., Caler E.;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR EMBL; KB207112; ELP84441.1; -; Genomic_DNA.
DR RefSeq; XP_004183787.1; XM_004183739.1.
DR AlphaFoldDB; A0A0A1TVL8; -.
DR EnsemblProtists; ELP84441; ELP84441; EIN_167460.
DR GeneID; 14883440; -.
DR KEGG; eiv:EIN_167460; -.
DR VEuPathDB; AmoebaDB:EIN_167460; -.
DR OrthoDB; 20775at2759; -.
DR Proteomes; UP000014680; Unassembled WGS sequence.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02248; Peptidase_C1A; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR InterPro; IPR039417; Peptidase_C1A_papain-like.
DR InterPro; IPR013201; Prot_inhib_I29.
DR PANTHER; PTHR12411:SF741; CATHEPSIN K; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:ELP84441.1};
KW Protease {ECO:0000313|EMBL:ELP84441.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000014680}.
FT DOMAIN 25..84
FT /note="Cathepsin propeptide inhibitor"
FT /evidence="ECO:0000259|SMART:SM00848"
FT DOMAIN 143..390
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
FT REGION 97..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ELP84441.1"
FT NON_TER 472
FT /evidence="ECO:0000313|EMBL:ELP84441.1"
SQ SEQUENCE 472 AA; 52969 MW; 82255BD9375DD14F CRC64;
MFFLLFLSTL ALAEFDLSND DFFLFKEFEL KYSKKYETPA QRLSKLALFR DSLKKIRELN
SQRTRKSDAI FGINYYSDLT PKEMGIVPHE HVSVPLDPQE INNGNKKGPK SVREFNTLPD
LPEGDELPDY LSYCGPYVEY NTDHPKVDFC GEQVNQNLCG CCYAAAVNNQ AQYVFANMTY
YKNNKDASKV QKLLFSPQRM IDTVFTNPST LSSNKRCCGG NSGTALLGQP TYSLQSDYPF
VDGKDANAGT LCNPRGDQNS AVKLQMRNNG FKMWTTVEKT GHKDKVMAIK KIIHMYGPIL
VAIDASRSGL KNYKSGIFSF PQTDTICNPN NVYTDHQVML VGYGKDEEDN REYFIGRNTW
YSSWGENNNY IKISTDVFCG IGEFIADNFL PSNYIIYSGS CVLDPNCESC NTKTLECTKC
AAGSNKDARG MCVKPDQYKN PIICALGKYG TYPECNKCLT GCKDCSDGAT CK
//
