ID   A0A0A1U148_ENTIV        Unreviewed;      1350 AA.
AC   A0A0A1U148;
DT   04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT   04-FEB-2015, sequence version 1.
DT   27-MAR-2024, entry version 42.
DE   SubName: Full=Guanine nucleotide exchange factor, putative {ECO:0000313|EMBL:ELP87735.1};
GN   ORFNames=EIN_410780 {ECO:0000313|EMBL:ELP87735.1};
OS   Entamoeba invadens IP1.
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=370355 {ECO:0000313|EMBL:ELP87735.1, ECO:0000313|Proteomes:UP000014680};
RN   [1] {ECO:0000313|EMBL:ELP87735.1, ECO:0000313|Proteomes:UP000014680}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IP1 {ECO:0000313|EMBL:ELP87735.1,
RC   ECO:0000313|Proteomes:UP000014680};
RA   Zafar N., Inman J., Hall N., Lorenzi H., Caler E.;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KB206788; ELP87735.1; -; Genomic_DNA.
DR   RefSeq; XP_004254506.1; XM_004254458.1.
DR   EnsemblProtists; ELP87735; ELP87735; EIN_410780.
DR   GeneID; 14886749; -.
DR   KEGG; eiv:EIN_410780; -.
DR   VEuPathDB; AmoebaDB:EIN_410780; -.
DR   OrthoDB; 68574at2759; -.
DR   Proteomes; UP000014680; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014680}.
FT   DOMAIN          126..249
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          287..527
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   REGION          1205..1350
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1205..1227
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1243..1261
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1269..1323
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1350 AA;  155083 MW;  11BA30F8EB706B3C CRC64;
     MEHIHQTHKQ QSIITRVFGG YTKHSSDSKS VVKESPLTHF LQSPKSFLTT QRLQIELTRT
     LTNIKLKEVP VIYLRPDDDG KSLELDDLNS TEEEKSKLIK IKKTESSPFF CNNIVDEVFA
     TYFKANVVRE NNAVMSGCVD SLINCACMED SDIMRAFVWT HSSFITSNEM LEKFKDRFEK
     CCCNDGILSQ QIKARIINGV KYWVEYTWQM NINQSMPIVE QTISFASLLR KYGMKKQALL
     ITDVVDRALN GNAVALIQIM KDTIPPVIQS LHSVFKLKRN VDVMDFPPKE FAKQITVFTS
     ELFRKIKLIE FLKSTSNSTK TECFNITEMT NFYNAFQAYF ADMILNESSL PRRAQIVSKL
     YMIAYHCFLL NNFDTVVCIV SLFETSALHR LKRTYKSINK DVVMFYEIAK KATSMENNWK
     NLRTTVESAT GAVVPYLGLI LSDLLFTTDG NKTITSDSTV NFAKCRKLSG IVIDVHRMKQ
     VSYKSTILVS EEYQKFIVEN IQKGPHTEKK ANNDSIQYNL SKQLEVTDCI TTEILTPEGG
     EGKVLLSVVL PNECTIRRFL PMKNKVAIGK IFNDVIGKEI DFEKKKIFFF FLENQPNEVY
     DAGKITDDIF YEHTFKTISF ATVLSNVKYI NCVFELSGVY VNCQIPLDMH KPLYQQFPII
     HTYLLKPFTF VPMRISSDYL VNGFLCVQYS LNEYNWNKEE ILFLVNIDSL PLYFSNLDVD
     ELRFKSFWNF KKIDVTLLEQ AESEQKDVYS LLTVDQFMLI YKNRIFQYCF PLDFVQVSLI
     VNIPNFVMKV QYDYPYEIIE STTSFAKRNP KIEIKFIGDD YNIEHIQEFI FHLHMSHPKF
     NKYQIFGINP EFVVQSSAYH IPKFVEELVT ALYFKDNFFD EKFFEHEATE DALCVIEKVE
     SGGEVVLSSL PYQTLSTIFF LYLYSLNIPL LPIDDIDKLA DFNKMNPEEQ KSTVINLYKT
     SAPSMRGLLN TIMELFVVWL LPNPSKLPAL KTFAKLLFVE LVEDDVAESI FNILVLLYPS
     LPALEIPQTT FTEMIHNYTL NPIMDEEVRN KHIDDIKESF SNNTPQAKLL LHKNSHFTLE
     KNPTRKPFKK IDTMTLRHSK ERKLKIGKNR TGTLQNEEAP NIATLQEKAK SPNLPYTDKS
     ITNFETDSSK FRSVSLSPRL RSSPIKQFTT VEEGKSCEEK QEEVQPSQVS PRICLTTKKD
     IVEESSGSVS IQSPVTPNFQ LQEESSDNSC KCDVKVDAPP TTPAFSKPKP PTLPKRPNFK
     APMPPSGSQK VERKSSQTVS PLKVAERTLS FSSTHVSMSQ TPKSQPAGGP YIRTNQRTAS
     NFEETRKMFG APATKEKPPL PRRKETQEQN
//