ID   A0A0A1U1N6_ENTIV        Unreviewed;       339 AA.
AC   A0A0A1U1N6;
DT   04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT   04-FEB-2015, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN   ORFNames=EIN_418020 {ECO:0000313|EMBL:ELP87953.1};
OS   Entamoeba invadens IP1.
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=370355 {ECO:0000313|EMBL:ELP87953.1, ECO:0000313|Proteomes:UP000014680};
RN   [1] {ECO:0000313|EMBL:ELP87953.1, ECO:0000313|Proteomes:UP000014680}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IP1 {ECO:0000313|EMBL:ELP87953.1,
RC   ECO:0000313|Proteomes:UP000014680};
RA   Zafar N., Inman J., Hall N., Lorenzi H., Caler E.;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR   EMBL; KB206772; ELP87953.1; -; Genomic_DNA.
DR   RefSeq; XP_004254724.1; XM_004254676.1.
DR   AlphaFoldDB; A0A0A1U1N6; -.
DR   EnsemblProtists; ELP87953; ELP87953; EIN_418020.
DR   GeneID; 14886977; -.
DR   KEGG; eiv:EIN_418020; -.
DR   VEuPathDB; AmoebaDB:EIN_418020; -.
DR   OrthoDB; 2962512at2759; -.
DR   Proteomes; UP000014680; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR004868; DNA-dir_DNA_pol_B_mt/vir.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR33568; DNA POLYMERASE; 1.
DR   PANTHER; PTHR33568:SF3; DNA-DIRECTED DNA POLYMERASE; 1.
DR   Pfam; PF03175; DNA_pol_B_2; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE   4: Predicted;
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014680};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          102..337
FT                   /note="DNA-directed DNA polymerase family B
FT                   mitochondria/virus"
FT                   /evidence="ECO:0000259|Pfam:PF03175"
SQ   SEQUENCE   339 AA;  40149 MW;  58EC84A32E8AAD5C CRC64;
     MFNKQRYNRD KQCYEVKDKN SSSIKLSDLI LYIRDHNRFE PYSLSDVNKR KEVNHSYWYA
     DFEASTQGYH NPYRVCYSKR GEDNIYNKYG KYCAYNFLCD LPHNAVCYFH NLKYDGSSLA
     KYNVNRCIKK GGKNMQMTLK IKGKQLTFKD SHALISTSLA SFPKMFGLSN IQKEIYPYNY
     FNKVNIENNI GTILEADKYE IKQWTEEQFE LFNEKIDKIE NCKIYEFQSD MKAYCVFYCN
     QDVKNLKQGH SIFRDMCLEY LNIDVDKVIS AASLANTYFK HNVYSKINNL KEYGGKVREF
     IQGAIYGGRC MTRDNKKWYV NDELYDYDAC SLYPSAINR
//