ID A0A0A1U1W3_ENTIV Unreviewed; 909 AA.
AC A0A0A1U1W3;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 08-NOV-2023, entry version 37.
DE RecName: Full=Myotubularin phosphatase domain-containing protein {ECO:0000259|PROSITE:PS51339};
GN ORFNames=EIN_162560 {ECO:0000313|EMBL:ELP86612.1};
OS Entamoeba invadens IP1.
OC Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC Entamoeba.
OX NCBI_TaxID=370355 {ECO:0000313|EMBL:ELP86612.1, ECO:0000313|Proteomes:UP000014680};
RN [1] {ECO:0000313|EMBL:ELP86612.1, ECO:0000313|Proteomes:UP000014680}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IP1 {ECO:0000313|EMBL:ELP86612.1,
RC ECO:0000313|Proteomes:UP000014680};
RA Zafar N., Inman J., Hall N., Lorenzi H., Caler E.;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-
CC phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
CC inositol) + phosphate; Xref=Rhea:RHEA:12316, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:57880, ChEBI:CHEBI:58088; EC=3.1.3.64;
CC Evidence={ECO:0000256|ARBA:ARBA00001291};
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DR EMBL; KB206960; ELP86612.1; -; Genomic_DNA.
DR RefSeq; XP_004185958.1; XM_004185910.1.
DR AlphaFoldDB; A0A0A1U1W3; -.
DR EnsemblProtists; ELP86612; ELP86612; EIN_162560.
DR GeneID; 14885519; -.
DR KEGG; eiv:EIN_162560; -.
DR VEuPathDB; AmoebaDB:EIN_162560; -.
DR OrthoDB; 7311at2759; -.
DR Proteomes; UP000014680; Unassembled WGS sequence.
DR GO; GO:0004438; F:phosphatidylinositol-3-phosphate phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14507; PTP-MTM-like; 1.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF8; PHOSPHATIDYLINOSITOL-3-PHOSPHATE PHOSPHATASE; 1.
DR Pfam; PF06602; Myotub-related; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000014680}.
FT DOMAIN 528..900
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
FT ACT_SITE 740
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR630564-1"
FT BINDING 650..653
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR630564-2"
FT BINDING 675..676
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR630564-2"
FT BINDING 740..746
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR630564-2"
SQ SEQUENCE 909 AA; 104787 MW; C3FBB636478076EE CRC64;
MSLEVFPDEA ENFYTLRILS TEVVDGIALL KVSVSSIELM WTIYRRWDEY VKYLISLQRI
TPVRLIVFKE QNQSVALSSK TSLESSISFL QNSTHQILAF DQVQAEIEKS SYLFDSFEPS
YITLKVIHQG FLEVKSSLSR YEDPFTKAFA VLSESNIFYM YHSPSEYSLP LFQATLPFLS
CVTVPENSNY IFVQISHKEI LMLKTPNYIE TEWWSKFFMR SVSKSHVPGI IKDAFKAISN
ESQSTFEHCC HEYNPHKKKV LRNEVKKQMQ SQNVSEAITK LKKKNIIKNV GEFVELSVQA
LTGATLPNIQ SALNSFVCLT VNDVVVTNSS NIKDVALTSA DVVRIQPINK EMQMLFDSTV
QNEAKFLTLK NANETPKTPG NLPLVYFPNE QLVMVYSNIV HIHTKYDCGP PTCCTGLDPI
PGTILITSAR LIFRVQRQSG TSESDGLFSS FHGKCKEEGF EIPIPLFYQI RKEKIALPTV
GIFSCVIVKC KNFHSFVLAF FDGEKADELE QIVIKAVSRR TMTEVFYFKG VYEGPNYLKD
FERMNYRKAG LSLYESGVKS YPSRIALPSQ MTPEDILQIV NFRSKGRIPA MSWWNYEKKM
YLLRSAQPLV GLTTTRNFAD EKLVEIARGM SESQKMTFVD CRPKLSASAN MIKGMGYEDS
RYYEGSDVVF LDIDNIHKMR ESYNQLFSAM RRISYAHVSM TEGMKIVANS KWLYHISKIL
KGTVIAINRM IQGSTLLVHC SDGWDRTSQI ASLIEIVVDP FYRTIEGFQV LIDKEWIAFG
HKFKDRCRHL VSTQSMNEYS PVFLQFIDCV FQIMRVAPKE FEYNENFLME IAQQSFSCYF
ANFLCNSQEE MNCKAESLWN VINKENIRFR FVNPTYKKSE KMLNVNDIEK SAPVLWRKFY
QSYFRFHSM
//