ID A0A0A1U2R0_ENTIV Unreviewed; 605 AA.
AC A0A0A1U2R0;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=EIN_227270 {ECO:0000313|EMBL:ELP88314.1};
OS Entamoeba invadens IP1.
OC Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC Entamoeba.
OX NCBI_TaxID=370355 {ECO:0000313|EMBL:ELP88314.1, ECO:0000313|Proteomes:UP000014680};
RN [1] {ECO:0000313|EMBL:ELP88314.1, ECO:0000313|Proteomes:UP000014680}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IP1 {ECO:0000313|EMBL:ELP88314.1,
RC ECO:0000313|Proteomes:UP000014680};
RA Zafar N., Inman J., Hall N., Lorenzi H., Caler E.;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC {ECO:0000256|ARBA:ARBA00006637}.
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DR EMBL; KB206756; ELP88314.1; -; Genomic_DNA.
DR RefSeq; XP_004255085.1; XM_004255037.1.
DR AlphaFoldDB; A0A0A1U2R0; -.
DR EnsemblProtists; ELP88314; ELP88314; EIN_227270.
DR GeneID; 14887293; -.
DR KEGG; eiv:EIN_227270; -.
DR VEuPathDB; AmoebaDB:EIN_227270; -.
DR OrthoDB; 1360679at2759; -.
DR Proteomes; UP000014680; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IEA:InterPro.
DR CDD; cd18789; SF2_C_XPB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR032438; ERCC3_RAD25_C.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001161; XPB/Ssl2.
DR InterPro; IPR032830; XPB/Ssl2_N.
DR NCBIfam; TIGR00603; rad25; 1.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF16203; ERCC3_RAD25_C; 1.
DR Pfam; PF13625; Helicase_C_3; 1.
DR Pfam; PF04851; ResIII; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000313|EMBL:ELP88314.1};
KW Helicase {ECO:0000313|EMBL:ELP88314.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000313|EMBL:ELP88314.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000014680}.
FT DOMAIN 207..359
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 414..568
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 605 AA; 69585 MW; D56484B844F64803 CRC64;
MEEEPQQNWH YPQESVIDRF ELEILNNTNP MWVCPNGRVL VETTKPQSKT AIAILMKISK
VTAQMDFFEE YQISDYTIFT ALTSGVDVMS VFAEFSKYSK NSIPHEVAEL FATANKKRVV
RVICDYDGVR ECFGDTELIQ ILAKEGAFAD NTTKMILNQN IVEFKNLCRT HKILVVEEVP
YGEQKLPFTL RDERVLRDYQ VSAISSVFEN NRVKCGIIVL PCGAGKTLLS IALICGMQQM
SIIICTSIAS VEQWRDEIRK WSTVPFNKIK CFTSSVKEPL DGCYVVLTTY QMMQSKEIEQ
VTRYLYGMMI LDEVHASVAN EFKEVYSKIN SRCRIGLTAT FVREDSKIGE LDFLTGPLLY
QQSWTKLIKD GFLAQVHCFE VVCNMTQVFY ERYVNEDEYR HRALASAANP TKIATVQFLV
KYHKNRKEQI IIFCDNIVVL REIASRVGCP VFSGETPNKS RFDLLKNFKN GLTPCIAMSS
VGDTSLDIPD ATVIIQMCTS HGSRRQQLQR LGRISRVKQN KGEAFFYSLT SKDTHEEYFV
RKRQEYMQNL GFGFQIIDNL KVTVIDEEEQ AKLLNLLIEK VDKRYVQHKK NKPQKDEFCD
DEDAE
//