ID A0A0A1U2W8_ENTIV Unreviewed; 506 AA.
AC A0A0A1U2W8;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Rho-GAP domain-containing protein {ECO:0000259|PROSITE:PS50238};
GN ORFNames=EIN_134430 {ECO:0000313|EMBL:ELP85899.1};
OS Entamoeba invadens IP1.
OC Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC Entamoeba.
OX NCBI_TaxID=370355 {ECO:0000313|EMBL:ELP85899.1, ECO:0000313|Proteomes:UP000014680};
RN [1] {ECO:0000313|EMBL:ELP85899.1, ECO:0000313|Proteomes:UP000014680}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IP1 {ECO:0000313|EMBL:ELP85899.1,
RC ECO:0000313|Proteomes:UP000014680};
RA Zafar N., Inman J., Hall N., Lorenzi H., Caler E.;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Rho GTPase-activating protein involved in the signal
CC transduction pathway. {ECO:0000256|ARBA:ARBA00037092}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB207027; ELP85899.1; -; Genomic_DNA.
DR RefSeq; XP_004185245.1; XM_004185197.1.
DR AlphaFoldDB; A0A0A1U2W8; -.
DR EnsemblProtists; ELP85899; ELP85899; EIN_134430.
DR GeneID; 14884903; -.
DR KEGG; eiv:EIN_134430; -.
DR VEuPathDB; AmoebaDB:EIN_134430; -.
DR OrthoDB; 25175at2759; -.
DR Proteomes; UP000014680; Unassembled WGS sequence.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00159; RhoGAP; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR45808; RHO GTPASE-ACTIVATING PROTEIN 68F; 1.
DR PANTHER; PTHR45808:SF2; RHO GTPASE-ACTIVATING PROTEIN 68F; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000014680}.
FT DOMAIN 320..506
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 83..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 506 AA; 57976 MW; 3294A1FC197C1C42 CRC64;
MEVLPTPRRP RPKAHLLKMS EFDVEEPFLT NSEGGRPTLS AMLMKSTLDT TQQQTNIVCT
TLDTLYFYKH HLELLSHNKL LNPTKQQCEP RSPRSPRKKS DADTSIEQLM KHYRKLGDHF
ISLTAQIANF QHHFASYSHK QLLQLFTSVY KVVPDTSDGD DVLYGTETMG KRMKVVKLCD
NFLLISKKTR TLESIYYISK AAIIPLSQVS LELNKYITLE FEDPSKFQTW LNKLNSVKPW
FEVVPRRLIK SPDNTSIFFN KVGVPVNSLG ITETSVDKTT KAMTPKSTQS PSMLSPRTKN
ILNIKFVKRT KTKTVKIVGL SLDQLANEHN FLHIPKNVSM LIKYIKEKGA HIEGIFRVSG
SKEKIELILS KVDSKIITFD LLASVDIHSV AGALKLYIKS LPDQVVPKSV DEKLYELWRF
KDSMQDNEVL NEFKEVFSTM PPLTYAFLRE LLDLLKILSD NQQETKMTVE NCVTCLQPSL
RGYPFVYTYS IIHYTTLFPP QTEITL
//
