ID A0A0A1U318_ENTIV Unreviewed; 1092 AA.
AC A0A0A1U318;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Rho/RAC guanine nucleotide exchange factor, putative {ECO:0000313|EMBL:ELP87100.1};
GN ORFNames=EIN_495550 {ECO:0000313|EMBL:ELP87100.1};
OS Entamoeba invadens IP1.
OC Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC Entamoeba.
OX NCBI_TaxID=370355 {ECO:0000313|EMBL:ELP87100.1, ECO:0000313|Proteomes:UP000014680};
RN [1] {ECO:0000313|EMBL:ELP87100.1, ECO:0000313|Proteomes:UP000014680}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IP1 {ECO:0000313|EMBL:ELP87100.1,
RC ECO:0000313|Proteomes:UP000014680};
RA Zafar N., Inman J., Hall N., Lorenzi H., Caler E.;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KB206864; ELP87100.1; -; Genomic_DNA.
DR RefSeq; XP_004253871.1; XM_004253823.1.
DR AlphaFoldDB; A0A0A1U318; -.
DR EnsemblProtists; ELP87100; ELP87100; EIN_495550.
DR GeneID; 14886096; -.
DR KEGG; eiv:EIN_495550; -.
DR VEuPathDB; AmoebaDB:EIN_495550; -.
DR OrthoDB; 24433at2759; -.
DR Proteomes; UP000014680; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF159; RAC GUANINE NUCLEOTIDE EXCHANGE FACTOR JJ; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Reference proteome {ECO:0000313|Proteomes:UP000014680};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 5..109
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 446..627
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 936..998
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REGION 123..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 232..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 320..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 538..569
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 123..159
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..178
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..260
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..385
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1092 AA; 122957 MW; E7BAA81751EC3F11 CRC64;
MSSFPDEIKE CVNWVNGQLP DEEPITDVLT GLSDGTKLIR IVAKLSGKKA LRYSLTANTP
FQKQQNMAVL LKMTEMAYGT NVSYDAGDLA RGNEGQLLSL AFYIGQKSGT RVPKRKTLTK
ATSIGLKNVQ PNANEQVSKN SPLRQTSDVA LNHTEKTQNK NNTNGDETDK MERSPRSPRK
VVIDVVPALP EKRYHNISSS KTVVQTRDIK ETTDSTDDGL DIPVDVIETT LTSQGVKEKS
QTDLEEESPI KSDMTESTEN NEEGSAHYSL YDEIEVLGKY DTFMETNKCT TPTVSESSYV
QPIVDTSSMC TVSTGVVESE ALHQETPPSQ LEDVPPPTPT LPQRPKRMLE SSMNKLCQSS
PSAGCKSSRE ASLSSGTSRM SFMSESGSGA KRDKIGKSPR DTISQMPEMS YDQKTYLEED
VDIINKYCRG YLGRLKAKPT MKMLSQRRNV VLEILNTERI YVSRLKQFLE FYLAKALQIF
PGDSILKKCE ENLRVIVGYN GNLLKELEQL QTEGKIYGEG IGKSFEKLSH FLKTYCSYIN
STDAINEHEE KLRRTKKEFE SQMKQTQLEN KLETFNSYVI LPVQRIPRYR LLLTELLKTM
TPQHGEYIAL DKSLQQIIEV GSAVNETKRT MEQKNIVSLV FSKFKYPTGM QQIQPDAACS
FVRIGNMELL DREKGKLKSV TLLLFSNNVV ITKVPTTGTL HKGKLKADSI ETIVESKKSL
TVEYVIPIGS FCVLDSADFM LGSGGLSERA PSFKIVTKDL LTFQFCTLTE SEKNSWLVDL
DSQVALVQER ALIGIRESNK NIIESLYDAY RSQWSENTIK MPWWHSDLMG EECMIFANGY
VATFGNAHDA FARQNIRNYF VTKYTSVAFS GQKTITLVNF ARKEKPRVVL ELNTTAEALM
WVFLLRQSFI GFYDPNEINM ALFSCAENDL PALPPEEVVF AITENAKNRT CADCGDTAVK
YVDMTFGCFV CSDCGRIHRY FTNKPQVCAP KILGDKSLVD LRLLIQKGND FLNEELVVGQ
GLPTNPAEYD GDLNQYLWKK YKQEGEAPKS IIREVGKKTG TLRRDEVNKI RAKRGMERRS
TFSVIEEDKK KK
//
