ID A0A0A1U4A0_ENTIV Unreviewed; 434 AA.
AC A0A0A1U4A0;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 08-NOV-2023, entry version 44.
DE SubName: Full=Rho/RAC guanine nucleotide exchange factor, putative {ECO:0000313|EMBL:ELP89058.1};
GN ORFNames=EIN_164980 {ECO:0000313|EMBL:ELP89058.1};
OS Entamoeba invadens IP1.
OC Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC Entamoeba.
OX NCBI_TaxID=370355 {ECO:0000313|EMBL:ELP89058.1, ECO:0000313|Proteomes:UP000014680};
RN [1] {ECO:0000313|EMBL:ELP89058.1, ECO:0000313|Proteomes:UP000014680}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IP1 {ECO:0000313|EMBL:ELP89058.1,
RC ECO:0000313|Proteomes:UP000014680};
RA Zafar N., Inman J., Hall N., Lorenzi H., Caler E.;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR EMBL; KB206683; ELP89058.1; -; Genomic_DNA.
DR RefSeq; XP_004255829.1; XM_004255781.1.
DR AlphaFoldDB; A0A0A1U4A0; -.
DR EnsemblProtists; ELP89058; ELP89058; EIN_164980.
DR GeneID; 14888023; -.
DR KEGG; eiv:EIN_164980; -.
DR VEuPathDB; AmoebaDB:EIN_164980; -.
DR OrthoDB; 10022at2759; -.
DR Proteomes; UP000014680; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF263; GRFA PROTEIN, PUTATIVE-RELATED; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000014680};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 16..202
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 232..322
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 346..404
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
SQ SEQUENCE 434 AA; 50177 MW; D5F6C81A060DEB8C CRC64;
MSFVKERENT LSGDEYRLRI IEEIMDTEKT YNESLDTCIQ YYYKRITEQS PPIIPKSQTE
TIFLYFDEIA NVNKSFYLEL QNAKESSTLS RSIGKIFQNY IPYFRVYYQY LGNTGPSQQA
VQTISTSKKI EDFLDDVRLA IPNKSNQLDL QGFLIMPVQR LPRYTLLLTD LVKRTPETYD
DYTNIKQALT EMKKLTDSAN RAIVSTERRR VLFALEKRIS GFSGKLVEPQ RYFIKEGNLR
KVCRKKIKPR HFILFNDIFL YGMGDEAATK VSQVTEVFSV FVKDVPQQNA FEILTDQKSF
VVYASNKEEK ESWMTEITKA NEEATRALKT RNKMNDSFIK PPFVPDNTVT LCMTCNTQFG
IWTRRHHCRF CGKCVCDGCT KMRVPLPPLM TLERACPGCV DRLLLSARPV EKRDKINSEI
YGSVSGLSST PPLV
//