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Database: UniProt
Entry: A0A0A1U4A0_ENTIV
LinkDB: A0A0A1U4A0_ENTIV
Original site: A0A0A1U4A0_ENTIV 
ID   A0A0A1U4A0_ENTIV        Unreviewed;       434 AA.
AC   A0A0A1U4A0;
DT   04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT   04-FEB-2015, sequence version 1.
DT   08-NOV-2023, entry version 44.
DE   SubName: Full=Rho/RAC guanine nucleotide exchange factor, putative {ECO:0000313|EMBL:ELP89058.1};
GN   ORFNames=EIN_164980 {ECO:0000313|EMBL:ELP89058.1};
OS   Entamoeba invadens IP1.
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=370355 {ECO:0000313|EMBL:ELP89058.1, ECO:0000313|Proteomes:UP000014680};
RN   [1] {ECO:0000313|EMBL:ELP89058.1, ECO:0000313|Proteomes:UP000014680}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IP1 {ECO:0000313|EMBL:ELP89058.1,
RC   ECO:0000313|Proteomes:UP000014680};
RA   Zafar N., Inman J., Hall N., Lorenzi H., Caler E.;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000256|ARBA:ARBA00004245}.
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DR   EMBL; KB206683; ELP89058.1; -; Genomic_DNA.
DR   RefSeq; XP_004255829.1; XM_004255781.1.
DR   AlphaFoldDB; A0A0A1U4A0; -.
DR   EnsemblProtists; ELP89058; ELP89058; EIN_164980.
DR   GeneID; 14888023; -.
DR   KEGG; eiv:EIN_164980; -.
DR   VEuPathDB; AmoebaDB:EIN_164980; -.
DR   OrthoDB; 10022at2759; -.
DR   Proteomes; UP000014680; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR001331; GDS_CDC24_CS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR000306; Znf_FYVE.
DR   InterPro; IPR017455; Znf_FYVE-rel.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR   PANTHER; PTHR12673:SF263; GRFA PROTEIN, PUTATIVE-RELATED; 1.
DR   Pfam; PF01363; FYVE; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00064; FYVE; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS00741; DH_1; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50178; ZF_FYVE; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000014680};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00091}.
FT   DOMAIN          16..202
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          232..322
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          346..404
FT                   /note="FYVE-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50178"
SQ   SEQUENCE   434 AA;  50177 MW;  D5F6C81A060DEB8C CRC64;
     MSFVKERENT LSGDEYRLRI IEEIMDTEKT YNESLDTCIQ YYYKRITEQS PPIIPKSQTE
     TIFLYFDEIA NVNKSFYLEL QNAKESSTLS RSIGKIFQNY IPYFRVYYQY LGNTGPSQQA
     VQTISTSKKI EDFLDDVRLA IPNKSNQLDL QGFLIMPVQR LPRYTLLLTD LVKRTPETYD
     DYTNIKQALT EMKKLTDSAN RAIVSTERRR VLFALEKRIS GFSGKLVEPQ RYFIKEGNLR
     KVCRKKIKPR HFILFNDIFL YGMGDEAATK VSQVTEVFSV FVKDVPQQNA FEILTDQKSF
     VVYASNKEEK ESWMTEITKA NEEATRALKT RNKMNDSFIK PPFVPDNTVT LCMTCNTQFG
     IWTRRHHCRF CGKCVCDGCT KMRVPLPPLM TLERACPGCV DRLLLSARPV EKRDKINSEI
     YGSVSGLSST PPLV
//
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