ID A0A0A1U8B7_ENTIV Unreviewed; 1198 AA.
AC A0A0A1U8B7;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Activating signal cointegrator 1 complex subunit 3, helc1, putative {ECO:0000313|EMBL:ELP91076.1};
DE Flags: Fragment;
GN ORFNames=EIN_268220 {ECO:0000313|EMBL:ELP91076.1};
OS Entamoeba invadens IP1.
OC Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC Entamoeba.
OX NCBI_TaxID=370355 {ECO:0000313|EMBL:ELP91076.1, ECO:0000313|Proteomes:UP000014680};
RN [1] {ECO:0000313|EMBL:ELP91076.1, ECO:0000313|Proteomes:UP000014680}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IP1 {ECO:0000313|EMBL:ELP91076.1,
RC ECO:0000313|Proteomes:UP000014680};
RA Zafar N., Inman J., Hall N., Lorenzi H., Caler E.;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KB206479; ELP91076.1; -; Genomic_DNA.
DR RefSeq; XP_004257847.1; XM_004257799.1.
DR AlphaFoldDB; A0A0A1U8B7; -.
DR EnsemblProtists; ELP91076; ELP91076; EIN_268220.
DR GeneID; 14890023; -.
DR KEGG; eiv:EIN_268220; -.
DR VEuPathDB; AmoebaDB:EIN_268220; -.
DR OrthoDB; 57056at2759; -.
DR Proteomes; UP000014680; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0034641; P:cellular nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0010467; P:gene expression; IEA:UniProt.
DR GO; GO:0044238; P:primary metabolic process; IEA:UniProt.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR47961; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR PANTHER; PTHR47961:SF13; SEC63 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00270; DEAD; 2.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF02889; Sec63; 1.
DR SMART; SM00382; AAA; 2.
DR SMART; SM00487; DEXDc; 2.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00973; Sec63; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 2.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000014680}.
FT DOMAIN 183..360
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 398..605
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1009..1183
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT REGION 94..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 693..720
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1055..1082
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1198
FT /evidence="ECO:0000313|EMBL:ELP91076.1"
SQ SEQUENCE 1198 AA; 136352 MW; 5D76DC23D67D8032 CRC64;
MPRQRKKQQP QTTGEYTWLR KFVTTSPLCE IIYQRLGLTP DELEASVESL VDMTSDEIQL
QTSLFEVYGD DAFEFIAEIC QNYPLIINRQ VVERPKQKRQ KTPNPESKPY VGRPQELMQR
PSIPQNAIER NLPDRYEMYI PAVPSAKSLM TERLEVKDIL DDLTRPAMLK YTHLNYVQSK
VYNCAYNSGD NMLVCAPTGC GKTLTALLCM LREVKMRIHD LSHLKIIYIS PLKALATEMT
NTFRKHLACF KMKVEEVTGD TNIPKVQLMA TNVIVATPEK FDVLTRKQDA EFVNDIQLLI
VDEVHLLDED RGAVIETIVA RTLRMVESQQ RPIRVVGLSA TLPNYLDVGE FIRAKKENIF
YFDMSYRAVP MSTKFIVLPE NEKDDRGNRF ISHATDVAFD EAEIVVKRGK QVIVFVHTRR
ETYLTAQRFI KKIREKADQE YFSGLKDREF ATRIKKLQGR DLKELLEMGI GVHNAGMFRS
DRTFVEDAFR NGTLKVLVST ATLAWGVNLP AHTVIIKGTE VFNSDKGCSD KISILDVLQM
FGRAGRPQFD TEGAGIIITD KEGQQKYLAI LGNMGKIKST LMNGLSDHLN AEIVSGTVAN
MEEALQWFQY TYLYVCLKRS EGGVGYDDLN SLIGGTVRNL ENLQMTLVND ETGMFSPTLL
GRIASHYYVT VESMFTFSEK LHEGMSMGSL LDLVCSSNEL KQLQKMREEE KKEMEEISRR
VKWAIKGDDL AANKANILIQ ASLSHTVLEN FTLISETLYA NQNASRVTRA LFELACIRSL
SSEAINLLEL TKMIDQQNWN TVHPLFQFKS LPVQVVLRLQ TKHIDVETIC EMDKNEFMDT
PQYATQIKQC ASEFPYLALD TSIIPLTSTI LQIKVHVHPT FRWGRDLGTI ENFWLFISDS
KYSQLFYFDS FMLNQKAIDD YNATGTPLEI IASVPVIHND QYVVDVVSDK YFGCTSTSPV
IFDESTLPDD ESFMTKLLRL NPLPTKATRQ YEDFFGFKFF NPPQTQFFFK CFHTDSNIIV
GAPTGSGKTV AAELCMLKVF RDTPSKKVVY VAPMKALVKE KLKDWRGKLK QMKKEIVELT
GDFTPDSSAI LKADVILTTP EKWDGVTRLW MKKSYIQKVG LVIIDEIHLL GEDRGPVIEA
IVTRTKQITE RLNVPIRICA LTTAIANVDD MMAWIGVERT SVFNFHSSLR PVPLIAHI
//
