ID A0A0A1UAV7_ENTIV Unreviewed; 764 AA.
AC A0A0A1UAV7;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, putative {ECO:0000313|EMBL:ELP92197.1};
DE EC=3.1.3.67 {ECO:0000313|EMBL:ELP92197.1};
GN ORFNames=EIN_381740 {ECO:0000313|EMBL:ELP92197.1};
OS Entamoeba invadens IP1.
OC Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC Entamoeba.
OX NCBI_TaxID=370355 {ECO:0000313|EMBL:ELP92197.1, ECO:0000313|Proteomes:UP000014680};
RN [1] {ECO:0000313|EMBL:ELP92197.1, ECO:0000313|Proteomes:UP000014680}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IP1 {ECO:0000313|EMBL:ELP92197.1,
RC ECO:0000313|Proteomes:UP000014680};
RA Zafar N., Inman J., Hall N., Lorenzi H., Caler E.;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KB206395; ELP92197.1; -; Genomic_DNA.
DR RefSeq; XP_004258968.1; XM_004258920.1.
DR AlphaFoldDB; A0A0A1UAV7; -.
DR EnsemblProtists; ELP92197; ELP92197; EIN_381740.
DR GeneID; 14891095; -.
DR KEGG; eiv:EIN_381740; -.
DR VEuPathDB; AmoebaDB:EIN_381740; -.
DR OrthoDB; 5477362at2759; -.
DR Proteomes; UP000014680; Unassembled WGS sequence.
DR GO; GO:0016314; F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0004722; F:protein serine/threonine phosphatase activity; IEA:RHEA.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:RHEA.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR CDD; cd14509; PTP_PTEN; 1.
DR Gene3D; 2.60.40.1110; -; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR006869; DUF547.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR045101; PTP_PTEN.
DR InterPro; IPR014020; Tensin_C2-dom.
DR InterPro; IPR029023; Tensin_phosphatase.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR12305; PHOSPHATASE WITH HOMOLOGY TO TENSIN; 1.
DR PANTHER; PTHR12305:SF60; PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE TPTE2-RELATED; 1.
DR Pfam; PF04784; DUF547; 1.
DR Pfam; PF10409; PTEN_C2; 1.
DR SMART; SM01326; PTEN_C2; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR PROSITE; PS51182; C2_TENSIN; 1.
DR PROSITE; PS51181; PPASE_TENSIN; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:ELP92197.1};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000014680}.
FT DOMAIN 14..186
FT /note="Phosphatase tensin-type"
FT /evidence="ECO:0000259|PROSITE:PS51181"
FT DOMAIN 100..160
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 191..364
FT /note="C2 tensin-type"
FT /evidence="ECO:0000259|PROSITE:PS51182"
SQ SEQUENCE 764 AA; 88155 MW; CB5A891927217141 CRC64;
MANVIREAVS KEKRRYQQFG FDLDLSYITP RIIAMGFPSE KFEAAYRNPL VDVLQFFETF
HKGHYKVYNF CREKPYDGES KIKGEYEYFP FDDHNAPEFR IIPQLCKDVD EYLSADPLNV
IALHCKAGKG RTGLMSAAFL VYMLDALNAH EAIDFYGTAR TFNKKGVTIP SQLKYINYWS
ASLKHKFTVG DRTVKMTKIE MIPTPKISDE IFVKVSTFTE FVCEKSLTNS RKLTFKPLKE
SKIKMKEEEY MKLYDEVLAE LKEENPNVTT REAMCAWDWK MRSIEGDERF GTDGSAFPID
PVTLHGDIKL EFSTSKGGIF NIWFNTWFIH DNHLEFSKME LDKGFKDAKQ LAPNFKVILN
FEDVSTAPSL EQEIPFCQVG VRSDIPDDIV DPEKVPPIPK SIATDPDVDA PKALLAETES
SENPKRVKAP VWYPIYHTSL NFKNFNRIVD HLIQYPSQRE FFNINPEMEV VKETTRDPLE
VARSVLYSVI QLYLRSGFYG RCFDYHIELI TLDNLAGVKL FEQQASELAV VDLEKLKTGE
NEPFWLNVYH IMLLHGLMYW KHRPNVEFKD MMSNFKKFAY KIGGFSYTLH DVLMGCLRAP
WPKDSSIDKV VTFSNEKAKY VMKEADKNLG CLLSFGTTTS PGIWLYSVED FAQQKEIAVN
TYLNRQAAAL GAKKQFYLMG NMKMFAKDYG GESAMKKELL QRHGVTDHDV KKWDLKYQSE
DTENRVILDH LIAQNIVVTH VPVNFLGQCS LFRYEKPTVK DPKA
//