ID A0A0A1UDM6_ENTIV Unreviewed; 2528 AA.
AC A0A0A1UDM6;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 08-NOV-2023, entry version 45.
DE RecName: Full=DOCKER domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=EIN_359320 {ECO:0000313|EMBL:ELP90849.1};
OS Entamoeba invadens IP1.
OC Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC Entamoeba.
OX NCBI_TaxID=370355 {ECO:0000313|EMBL:ELP90849.1, ECO:0000313|Proteomes:UP000014680};
RN [1] {ECO:0000313|EMBL:ELP90849.1, ECO:0000313|Proteomes:UP000014680}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IP1 {ECO:0000313|EMBL:ELP90849.1,
RC ECO:0000313|Proteomes:UP000014680};
RA Zafar N., Inman J., Hall N., Lorenzi H., Caler E.;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR EMBL; KB206483; ELP90849.1; -; Genomic_DNA.
DR RefSeq; XP_004257620.1; XM_004257572.1.
DR EnsemblProtists; ELP90849; ELP90849; EIN_359320.
DR GeneID; 14889866; -.
DR KEGG; eiv:EIN_359320; -.
DR VEuPathDB; AmoebaDB:EIN_359320; -.
DR OrthoDB; 23305at2759; -.
DR Proteomes; UP000014680; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08679; C2_DOCK180_related; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF76; LD20667P; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000014680}.
FT DOMAIN 495..671
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 2072..2520
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 1131..1182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1486..1527
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1136..1174
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2528 AA; 293773 MW; F2FD68C436E2857D CRC64;
MEHQLDTSVL SQIFETDFRK TKVVMATPER GSNPIQKTET SLKILSKFDL YDTENNKELD
VYQLRKYIEG EWKICLSEES IKYHCGQNFL EKAYKVQRNE FIAFHKYITA NLEEIKKENT
QSDLEVFESQ FTEDSPVDSQ YKLLDKNCFV IEKLDKFHSI MYPDLIPPEK GDPIHCDMYN
VIFGKTISIY KKHIPFRSVF TTIPDNFVPK NDNLKKLFSI DSLFQSITNK VGQRRKKAKN
FFEFFDKKIS HTDFLYSTNL SNARDEDIEV LKKYKKPSVI EMVNIKLPLN IEKLHCRLSF
YDTNYIKLSA DYCFNVDPSD LQASTLNVPL SSFVMRQEII NKSVAFIVVF QVFKAMDADI
SFAREVYAND NKRDAKNVKK YSDRVKESAK FFEQKKYQLL MFSSKQILFT GNYELFKLYK
PPNEVKDIVW MIKECDKWKL CGEWTFKFKA SKKELVHVDG ESEFNNQEHE EKPIFIKSLT
NLSLQDSEDI FTDYRNFLFC YPTELCLGKE RKRGGCLITV YCRDTDAKFA GEITGNLPVI
FPNNSSCHVD MQTSLTTTVA TEKVGKFTDE IKLELPFPLT PTHHLLFCVR DIGTDDGVEG
RPLFAKLPLY ENGRVVENKE YTLRIMKEMN DHYLKTNEYY DQSKMYLKVT INVVSTVYPT
ERVLTDFLYF NAPVDTVLYP DLYTEMIHFL PSVLHRCLRI LQDRNREEIF SMFKLFKVFD
VNKNVEEEKK ESFSVYKNKN VVYAINHFVR VKTDENVYNC MFIVASLPII FDRSETNATE
RLKYIWIIFA LLIKSLIAFY NDHNAFNLPN FHTFCCGEDA KIISANLVKN IDMCSDFIVY
CSALSFVDPL VVREANLFYA EFIRDFAMLW RHDDTTKLVI SHLDNICKMS RDVIGRSSSS
FSRLLRLEFI SVLAEGDHIF QLNGPQNLEV KGINKLNDTI AQRHTLMFII LRQFFVLILD
QDKLISKMAL HELVLLMNKF DLDKSLSSQH DRERFFGMMF PFVLFFLDDS EKINEWRKKD
CTSDLNDIEC LYMIFFFILK NLEDNLLDQW LVAEYLPSML NTLLVHIRKA LLLFSVFPMQ
TLPDAPKLYL KELQTLLNSI ETQSAPNIAR SPSPGLSKIG SSLKMHVKNN SQNKRLSSKY
KKDDDVKEPS TPRVGLDRLK LKKYDDDEEG RRSVSPRGSG SGAAMEYAKM SATPVFSNLS
CSAGARTITV SSCETADPNV LNMITDVSLI AMDYLEIMIS VLIRDDKTQA MDRIQEIVSD
VLFKIKTTPS YLVSLYKFIF IVLTTYREFL FLKPNQMCIN LLKNLLSLSN SQEVMERDFA
NNLLFTFAKT NFIVTGNTVS TIVSAISALS ELNLANVQNV KTSVKGLLEL SSQYHYTFDL
KLQRCVELLL DEGSRKIEAL QKVQQIYRAI DGGNLDVFIT FVKDCMLVFE DIIEFATTAN
TTVINGYDVF KSEVGGLLKT NEIFKMVGKW IIFIEHIQLC PKDSFYLFLE EKKKELRNSY
THLEETIVEL EKLCVTEKEQ MKRFEKQCDE NKTVGNRLFT WVKTNLQVQA IDYDTCEDSQ
LINIIEDLEK EQNKRVNGIK SHIEKYCQFD EVLKEMGLLV NPLFPVTSQE MGECVKKVLQ
LHQNRIKLVH QLIHVRTSYD TEYLIYTEKL KHFEKTLETM NSDIAVEISS KPITGHFLED
SMYRYKMLDD LFSTCSKKLN AKKVKMGGMK PTWEITYNGW EDVISLVLST LELTTNLLEK
VKQNDYEVIA MKEWYLKETK FNKTIIGVFM WDGMYSALNK VAMKESNDFL EILAGVYEYL
STHLKDVETR YNECVDILQH LRKKKLPLGF KYLQKKINVK DFEMLAMSTE LYVDQFNEEK
TLEKSRKEYA DLFVHFFKFT DKLCDDADKM QGLQNTKAVT GNTSITNLST YFKQKDHTID
PKVLEEISKQ REKLLSFEEQ KIDKLNRYCD LTQITQTVLT RCSLLGLPDK EKEPLKISYN
AKIPRSVSLP KSNNKLVELK DVLSFFMDSK DCIKLDCFHD LSYGQRDNFN KDLKNVEDDI
LNVLDSLEDI NTQKRESSDP QLVLQRFEGF AMNYVAAPQL HLTWMTRLAQ QHRDRGQYVE
AGMCEIHMVL FIHRLLENNT RTVDCSEFVA TFGNFVENTS TAPSSQFTAH FTEEMMIKHI
SNAADDFEKG NIAWYGLVTA NVLIPYYIEK RTIKELGKTH DYVNRMYSTL VSGNSDHFGR
DNLAFYYVQF VGKVFGEKLD GKKYIYVSTR NKMPMLIKEI KDVVPKSFKG ERHIISSLDK
MNEQLAISGD AENQCHIVFS QITPLYEKGK FVQYASKFNF DCLMCDEGKD PTVITNWFKN
RIVLETNLVL PGVLRRQEVT QKEQFYRMSA IEIAIDEIER KTEDLKFYLD ESFNFLKETD
DESAKLIVKK TSEILCGSND IGNERLAPKL TVFEKKKLVE FLHIFFYELQ DENINSTVLT
NLFNASKEAL AVVREAIAVV NETYRNVIVN ETTRSNIENI ERQADRVDYT LDEIENTMKS
QLGEDDNL
//
