ID A0A0A1UGQ0_ENTIV Unreviewed; 495 AA.
AC A0A0A1UGQ0;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=inositol-3-phosphate synthase {ECO:0000256|ARBA:ARBA00012125};
DE EC=5.5.1.4 {ECO:0000256|ARBA:ARBA00012125};
GN ORFNames=EIN_312850 {ECO:0000313|EMBL:ELP92913.1};
OS Entamoeba invadens IP1.
OC Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC Entamoeba.
OX NCBI_TaxID=370355 {ECO:0000313|EMBL:ELP92913.1, ECO:0000313|Proteomes:UP000014680};
RN [1] {ECO:0000313|EMBL:ELP92913.1, ECO:0000313|Proteomes:UP000014680}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IP1 {ECO:0000313|EMBL:ELP92913.1,
RC ECO:0000313|Proteomes:UP000014680};
RA Zafar N., Inman J., Hall N., Lorenzi H., Caler E.;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate;
CC Xref=Rhea:RHEA:10716, ChEBI:CHEBI:58401, ChEBI:CHEBI:61548;
CC EC=5.5.1.4; Evidence={ECO:0000256|ARBA:ARBA00000113};
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC -!- PATHWAY: Polyol metabolism; myo-inositol biosynthesis; myo-inositol
CC from D-glucose 6-phosphate: step 1/2. {ECO:0000256|ARBA:ARBA00005117}.
CC -!- SIMILARITY: Belongs to the myo-inositol 1-phosphate synthase family.
CC {ECO:0000256|ARBA:ARBA00010813}.
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DR EMBL; KB206312; ELP92913.1; -; Genomic_DNA.
DR RefSeq; XP_004259684.1; XM_004259636.1.
DR AlphaFoldDB; A0A0A1UGQ0; -.
DR EnsemblProtists; ELP92913; ELP92913; EIN_312850.
DR GeneID; 14891909; -.
DR KEGG; eiv:EIN_312850; -.
DR VEuPathDB; AmoebaDB:EIN_312850; -.
DR OrthoDB; 1201882at2759; -.
DR UniPathway; UPA00823; UER00787.
DR Proteomes; UP000014680; Unassembled WGS sequence.
DR GO; GO:0004512; F:inositol-3-phosphate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006021; P:inositol biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0008654; P:phospholipid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR002587; Myo-inos-1-P_Synthase.
DR InterPro; IPR013021; Myo-inos-1-P_Synthase_GAPDH.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR11510:SF5; INOSITOL-3-PHOSPHATE SYNTHASE 1; 1.
DR PANTHER; PTHR11510; MYO-INOSITOL-1 PHOSPHATE SYNTHASE; 1.
DR Pfam; PF01658; Inos-1-P_synth; 1.
DR Pfam; PF07994; NAD_binding_5; 2.
DR PIRSF; PIRSF015578; Myoinos-ppht_syn; 2.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Inositol biosynthesis {ECO:0000256|ARBA:ARBA00022550};
KW Isomerase {ECO:0000313|EMBL:ELP92913.1};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000014680}.
FT DOMAIN 291..404
FT /note="Myo-inositol-1-phosphate synthase GAPDH-like"
FT /evidence="ECO:0000259|Pfam:PF01658"
SQ SEQUENCE 495 AA; 55556 MW; BFFB6445DCF1D3E8 CRC64;
MAYTFNTTKS HSTADFIEAD FKYETTQVEV KPEGVVCTPK SQDYKFKVNK KVPKMGLMMI
GWGGNNGTTV TAGILANKHH LCWTDKRGVH EPNYYGSYTQ SATMRLGITT EGEEIYAPYK
EILPMVCPDD IVLGGWDISK TNMADALKRA QVVDYDLQKQ LYPYIKDWVP LPSIYYKSYI
AANQDDRADN VIPGNKQNHL DTVRKNIRDF KAAHGLDRVV ILWTATTERY VELKAGLNDT
ADNLLKAIAN DEEEVSHQLS LRPLLSWKDA RVIELAEKHN GAVMGDDFKT GQTKIKSVLA
DFLVSSGLKL QSIVSYNHLG NNDGKNLSSP NQFRSKEISK SNVVSDVVKS NTIMYKKGEH
PDHVIVIKYV PYVGDSKRAM DEYTSEIFLG GHNTIALHNT CEDSLLAAPL MIDLAVLMEF
MTRITYSVEG KEFSHFNAVM SFLSYLLKAP VVPKGTPVVN ALFKQRECLD NLFRALLGLP
AENHMLLEGK TQSFF
//
