ID   A0A0A1VMX1_9BURK        Unreviewed;      1045 AA.
AC   A0A0A1VMX1;
DT   04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT   04-FEB-2015, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   SubName: Full=Cation/multidrug efflux pump {ECO:0000313|EMBL:GAD24816.1};
GN   ORFNames=AVS7_04576 {ECO:0000313|EMBL:GAD24816.1};
OS   Acidovorax sp. MR-S7.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Acidovorax.
OX   NCBI_TaxID=1268622 {ECO:0000313|EMBL:GAD24816.1};
RN   [1] {ECO:0000313|EMBL:GAD24816.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MR-S7 {ECO:0000313|EMBL:GAD24816.1};
RX   DOI=10.1128/genomeA.00412-13;
RA   Miura T., Kusada H., Kamagata Y., Hanada S., Kimura N.;
RT   "Genome Sequence of the Multiple-beta-Lactam-Antibiotic-Resistant Bacterium
RT   Acidovorax sp. Strain MR-S7.";
RL   Genome Announc. 1:e00412-13(2013).
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DR   EMBL; DF238999; GAD24816.1; -; Genomic_DNA.
DR   RefSeq; WP_020230988.1; NZ_DF238999.1.
DR   AlphaFoldDB; A0A0A1VMX1; -.
DR   STRING; 1268622.AVS7_04576; -.
DR   eggNOG; COG0841; Bacteria.
DR   OrthoDB; 9757940at2; -.
DR   Proteomes; UP000030646; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR   Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR   Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   PANTHER; PTHR32063; -; 1.
DR   PANTHER; PTHR32063:SF18; CATION EFFLUX SYSTEM PROTEIN; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030646};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        344..365
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        377..401
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        413..432
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        453..472
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        484..506
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        546..564
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        883..902
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        909..929
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        935..956
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        984..1003
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1009..1033
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   1045 AA;  114194 MW;  68868EE5FCB2F1EA CRC64;
     MSIEPKGGFN LSKWALEHAA LTRYLMVVLM VLGIAAYFQL GQDEDPPFTF RAMVVRTYWP
     GATAQQVAEQ VTDKIERTLQ EVPYADKIRS YSKPGESQVI FEIKDSSKPA EVANVWYTVR
     KKIGDMRYQL PGNIQGPFFN DEFGDVYGVI YALHGEGFSY AELRDFADDV RQRLLRVKDV
     AKVEQFGVQD EKIWIEVSQK RLAQLGLDFN GVLQQLGSQN AVESAGAIQS PQDVVQVRVG
     GQFASVEELR AMPIRGAQSA AQLRLGDIAE VRRGYVDPPA VKVRFQGHEV IGLGISMAKG
     GDIIALGKAL RATVQEIQAQ LPAGVQLAQV QDQPAAVASS VNEFVKVLIE AVVIVLGVSF
     VSLGLHKGGR FGWYIDYRPG LVVAITIPLV LAVTFLAMHY FGIGLHKVSL GSLIIALGLL
     VDDAIIAVEM MVRKMEEGYD KVRAATFAYD VTAKPMLTGT LITAAGFLPI GIAKSVTGEY
     TFAIFAVTVI ALVLSWIVSV YFVPYLGTLL LKVKPHDPEA PPHELFDTPF YARFRAMVDW
     CVQHRWLTIG ATLLIFALGL VGMGKVQQQF FPDSSRPEVM VDIWFPEGTS FLANEAVARR
     LEQRLMQEEG VESVATWVGS GTPRFYLPLD QVFPQTNVSQ FIVLAKSLRE REALRLRLPE
     VLAQDFPEVR SRVKLLPNGP PVPYPVQFRI VGSDPAALRL RADEVKAAMR ANTQMIGVND
     NWNESVKVVR LEVDQEKARA LGVSSQSIAQ AARTLFSGTA VGQYREGDRL IEIVLRQSPD
     EREAISDIGN AYLPTASGRS IPLTQIARPV FTWEPGVMWR WNRNYAITVQ GDVVEGLQGA
     TVTAQLLPGL RELEAGWHAA GDTGVRIEVA GAVEESSKGS ASIVAGVPVM LFIVFTLLML
     QLHSFSRSVL VFLTGPLGIA GVAAALLLLG RPFGFVALLG VIALMGMIQR NSVILIDQIE
     LNRAAGVPAW DAIVTATVGR MRPIVLTAAA AVLAMIPLSR SVFWGPMAVA IMGGLIVATV
     LTLLALPAMY AAWFRVRREE PPQAG
//