ID A0A0A2E363_9PORP Unreviewed; 363 AA.
AC A0A0A2E363;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Peptide chain release factor 1 {ECO:0000256|HAMAP-Rule:MF_00093};
DE Short=RF-1 {ECO:0000256|HAMAP-Rule:MF_00093};
GN Name=prfA {ECO:0000256|HAMAP-Rule:MF_00093,
GN ECO:0000313|EMBL:SUB87966.1};
GN ORFNames=HQ47_07370 {ECO:0000313|EMBL:KGN73296.1}, NCTC11632_00024
GN {ECO:0000313|EMBL:SUB87966.1};
OS Porphyromonas macacae.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Porphyromonadaceae;
OC Porphyromonas.
OX NCBI_TaxID=28115 {ECO:0000313|EMBL:KGN73296.1, ECO:0000313|Proteomes:UP000030103};
RN [1] {ECO:0000313|EMBL:KGN73296.1, ECO:0000313|Proteomes:UP000030103}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=COT-192 OH2859 {ECO:0000313|Proteomes:UP000030103}, and
RC COT-192_OH2859 {ECO:0000313|EMBL:KGN73296.1};
RA Wallis C., Deusch O., O'Flynn C., Davis I., Horsfall A., Kirkwood N.,
RA Harris S., Eisen J.A., Coil D.A., Darling A.E., Jospin G., Alexiev A.;
RT "Draft Genome Sequence of Porphyromonas macacae COT-192_OH2859.";
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:SUB87966.1, ECO:0000313|Proteomes:UP000254156}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC11632 {ECO:0000313|EMBL:SUB87966.1,
RC ECO:0000313|Proteomes:UP000254156};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Peptide chain release factor 1 directs the termination of
CC translation in response to the peptide chain termination codons UAG and
CC UAA. {ECO:0000256|ARBA:ARBA00002986, ECO:0000256|HAMAP-Rule:MF_00093}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00093}.
CC -!- PTM: Methylated by PrmC. Methylation increases the termination
CC efficiency of RF1. {ECO:0000256|HAMAP-Rule:MF_00093}.
CC -!- SIMILARITY: Belongs to the prokaryotic/mitochondrial release factor
CC family. {ECO:0000256|ARBA:ARBA00010835, ECO:0000256|HAMAP-
CC Rule:MF_00093}.
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DR EMBL; JRFA01000023; KGN73296.1; -; Genomic_DNA.
DR EMBL; UGTF01000002; SUB87966.1; -; Genomic_DNA.
DR RefSeq; WP_036851534.1; NZ_UGTF01000002.1.
DR AlphaFoldDB; A0A0A2E363; -.
DR STRING; 28115.HQ47_07370; -.
DR eggNOG; COG0216; Bacteria.
DR OrthoDB; 9806673at2; -.
DR Proteomes; UP000030103; Unassembled WGS sequence.
DR Proteomes; UP000254156; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016149; F:translation release factor activity, codon specific; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.160.20; -; 1.
DR Gene3D; 3.30.70.1660; -; 2.
DR Gene3D; 6.10.140.1950; -; 1.
DR HAMAP; MF_00093; Rel_fac_1; 1.
DR InterPro; IPR005139; PCRF.
DR InterPro; IPR000352; Pep_chain_release_fac_I.
DR InterPro; IPR045853; Pep_chain_release_fac_I_sf.
DR InterPro; IPR004373; RF-1.
DR NCBIfam; TIGR00019; prfA; 1.
DR PANTHER; PTHR43804; LD18447P; 1.
DR PANTHER; PTHR43804:SF7; LD18447P; 1.
DR Pfam; PF03462; PCRF; 1.
DR Pfam; PF00472; RF-1; 1.
DR SMART; SM00937; PCRF; 1.
DR SUPFAM; SSF75620; Release factor; 1.
DR PROSITE; PS00745; RF_PROK_I; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00093};
KW Methylation {ECO:0000256|ARBA:ARBA00022481, ECO:0000256|HAMAP-
KW Rule:MF_00093}; Protein biosynthesis {ECO:0000256|HAMAP-Rule:MF_00093};
KW Reference proteome {ECO:0000313|Proteomes:UP000030103}.
FT DOMAIN 233..249
FT /note="Prokaryotic-type class I peptide chain release
FT factors"
FT /evidence="ECO:0000259|PROSITE:PS00745"
FT MOD_RES 240
FT /note="N5-methylglutamine"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00093"
SQ SEQUENCE 363 AA; 40670 MW; 7C6BC97F9DE6B762 CRC64;
MTADNNELLQ RIEGLHARFE EISTMIASPE VIADQKRYAK LSKEYRDLQK ILDKGNEYKN
AIDTIQEGRE TMQNEGDPEL REMARELIGE AEEKLPRLED EIKMLLVPAD PEDEKNAVME
IRGGTGGDEA AIFAGDLYKM YIKYCESKGW KTEVTSYTEG TAGGFKEIIF TVTGEGVYGV
LKYESGVHRV QRVPATETQG RVHTSAATVA VLPEADEVDV EINPADVEMQ TSRSGGAGGQ
NVNKVETKVQ LTHKPTGIVV ICQEARTQTG NRELAWQMLR NKLYEIEITK HNEAIASKRK
TMVSTGDRSA KIRTYNYPQG RVTDHRINLT LYNLSAIMDG DVQPIIDELI VAENIERMKE
AEL
//
