ID A0A0A2EF62_9PORP Unreviewed; 181 AA.
AC A0A0A2EF62;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Hypoxanthine phosphoribosyltransferase {ECO:0000313|EMBL:KGN75074.1};
DE SubName: Full=Hypoxanthine-guanine phosphoribosyltransferase {ECO:0000313|EMBL:SUB78047.1};
DE EC=2.4.2.8 {ECO:0000313|EMBL:SUB78047.1};
GN Name=hpt {ECO:0000313|EMBL:SUB78047.1};
GN ORFNames=HQ47_03995 {ECO:0000313|EMBL:KGN75074.1}, NCTC11632_01366
GN {ECO:0000313|EMBL:SUB89264.1}, NCTC13100_01200
GN {ECO:0000313|EMBL:SUB78047.1};
OS Porphyromonas macacae.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Porphyromonadaceae;
OC Porphyromonas.
OX NCBI_TaxID=28115 {ECO:0000313|EMBL:KGN75074.1, ECO:0000313|Proteomes:UP000030103};
RN [1] {ECO:0000313|EMBL:KGN75074.1, ECO:0000313|Proteomes:UP000030103}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=COT-192 OH2859 {ECO:0000313|Proteomes:UP000030103}, and
RC COT-192_OH2859 {ECO:0000313|EMBL:KGN75074.1};
RA Wallis C., Deusch O., O'Flynn C., Davis I., Horsfall A., Kirkwood N.,
RA Harris S., Eisen J.A., Coil D.A., Darling A.E., Jospin G., Alexiev A.;
RT "Draft Genome Sequence of Porphyromonas macacae COT-192_OH2859.";
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000254156, ECO:0000313|Proteomes:UP000254263}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC11632 {ECO:0000313|EMBL:SUB89264.1,
RC ECO:0000313|Proteomes:UP000254156}, and NCTC13100
RC {ECO:0000313|EMBL:SUB78047.1, ECO:0000313|Proteomes:UP000254263};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=diphosphate + GMP = 5-phospho-alpha-D-ribose 1-diphosphate +
CC guanine; Xref=Rhea:RHEA:25424, ChEBI:CHEBI:16235, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:58017, ChEBI:CHEBI:58115; EC=2.4.2.8;
CC Evidence={ECO:0000256|ARBA:ARBA00000210};
CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:25426;
CC Evidence={ECO:0000256|ARBA:ARBA00000210};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate +
CC hypoxanthine; Xref=Rhea:RHEA:17973, ChEBI:CHEBI:17368,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:58017, ChEBI:CHEBI:58053; EC=2.4.2.8;
CC Evidence={ECO:0000256|ARBA:ARBA00001442};
CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:17975;
CC Evidence={ECO:0000256|ARBA:ARBA00001442};
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DR EMBL; JRFA01000009; KGN75074.1; -; Genomic_DNA.
DR EMBL; UGTI01000001; SUB78047.1; -; Genomic_DNA.
DR EMBL; UGTF01000002; SUB89264.1; -; Genomic_DNA.
DR RefSeq; WP_018361253.1; NZ_UGTI01000001.1.
DR AlphaFoldDB; A0A0A2EF62; -.
DR STRING; 28115.HQ47_03995; -.
DR eggNOG; COG0634; Bacteria.
DR OrthoDB; 9802824at2; -.
DR Proteomes; UP000030103; Unassembled WGS sequence.
DR Proteomes; UP000254156; Unassembled WGS sequence.
DR Proteomes; UP000254263; Unassembled WGS sequence.
DR GO; GO:0052657; F:guanine phosphoribosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0004422; F:hypoxanthine phosphoribosyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd06223; PRTases_typeI; 1.
DR Gene3D; 3.40.50.2020; -; 1.
DR InterPro; IPR000836; PRibTrfase_dom.
DR InterPro; IPR029057; PRTase-like.
DR PANTHER; PTHR43340:SF1; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; 1.
DR PANTHER; PTHR43340; HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE; 1.
DR Pfam; PF00156; Pribosyltran; 1.
DR SUPFAM; SSF53271; PRTase-like; 1.
PE 4: Predicted;
KW Glycosyltransferase {ECO:0000313|EMBL:KGN75074.1};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000030103};
KW Transferase {ECO:0000313|EMBL:KGN75074.1}.
FT DOMAIN 18..163
FT /note="Phosphoribosyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00156"
SQ SEQUENCE 181 AA; 20943 MW; 61B45F7D1DE37300 CRC64;
MKEIKLRDYK FELYIEEQTI LSSIKKMGEQ IKRDFEGKNP LFVCVMNGSF VFASELFMTI
NEGYDVAFAR YSSYSGTSST MELKEHMPVS MPVEGRTVIL IEDLIDTGYT MKCVKERFYE
LGAKEVFIAA MLQKPKALKC DVTTDYVCLE IDNEFIVGHG LDYDNMGRMY RDIYKIKSLD
N
//
