ID A0A0A2FJ63_9PORP Unreviewed; 400 AA.
AC A0A0A2FJ63;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE RecName: Full=L-methionine gamma-lyase {ECO:0000256|ARBA:ARBA00019040};
DE EC=4.4.1.11 {ECO:0000256|ARBA:ARBA00012222};
GN Name=mdeA {ECO:0000313|EMBL:SQH73377.1};
GN ORFNames=HQ45_02695 {ECO:0000313|EMBL:KGN91028.1}, NCTC12858_01232
GN {ECO:0000313|EMBL:SQH73377.1};
OS Porphyromonas crevioricanis.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Porphyromonadaceae;
OC Porphyromonas.
OX NCBI_TaxID=393921 {ECO:0000313|EMBL:KGN91028.1, ECO:0000313|Proteomes:UP000030139};
RN [1] {ECO:0000313|EMBL:KGN91028.1, ECO:0000313|Proteomes:UP000030139}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=COT-253 OH2125 {ECO:0000313|Proteomes:UP000030139}, and
RC COT-253_OH2125 {ECO:0000313|EMBL:KGN91028.1};
RA Wallis C., Deusch O., O'Flynn C., Davis I., Jospin G., Darling A.E.,
RA Coil D.A., Alexiev A., Horsfall A., Kirkwood N., Harris S., Eisen J.A.;
RT "Porphyromonas crevioricanis strain:COT-253_OH2125 Genome sequencing.";
RL Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:SQH73377.1, ECO:0000313|Proteomes:UP000249300}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC12858 {ECO:0000313|EMBL:SQH73377.1,
RC ECO:0000313|Proteomes:UP000249300};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + L-methionine = 2-oxobutanoate + methanethiol + NH4(+);
CC Xref=Rhea:RHEA:23800, ChEBI:CHEBI:15377, ChEBI:CHEBI:16007,
CC ChEBI:CHEBI:16763, ChEBI:CHEBI:28938, ChEBI:CHEBI:57844; EC=4.4.1.11;
CC Evidence={ECO:0000256|ARBA:ARBA00000271};
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|RuleBase:RU362118};
CC -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family. L-
CC methionine gamma-lyase subfamily. {ECO:0000256|ARBA:ARBA00008667}.
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DR EMBL; JQJB01000003; KGN91028.1; -; Genomic_DNA.
DR EMBL; LS483447; SQH73377.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0A2FJ63; -.
DR STRING; 393921.HQ45_02695; -.
DR KEGG; pcre:NCTC12858_01232; -.
DR eggNOG; COG0626; Bacteria.
DR OrthoDB; 9803729at2; -.
DR Proteomes; UP000030139; Unassembled WGS sequence.
DR Proteomes; UP000249300; Chromosome 1.
DR GO; GO:0018826; F:methionine gamma-lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR CDD; cd00614; CGS_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR InterPro; IPR006237; L-Met_gamma_lys.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR NCBIfam; TIGR01328; met_gam_lyase; 1.
DR PANTHER; PTHR11808:SF80; GAMMA-CYSTATHIONASE; 1.
DR PANTHER; PTHR11808; TRANS-SULFURATION ENZYME FAMILY MEMBER; 1.
DR Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR PIRSF; PIRSF001434; CGS; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR PROSITE; PS00868; CYS_MET_METAB_PP; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:KGN91028.1};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR001434-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000249300}.
FT MOD_RES 213
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ SEQUENCE 400 AA; 43662 MW; A5691873779FC2B2 CRC64;
MMKNEELKKS GFATRAIHAG SVENEFGTLA APIYQTSTFV FENAAQGGRR FALEEEGYIY
TRLGNPTCTM VEEKLAMLEG GEAACSMSSG IGAISSAIWV LVKAGDHIVA GKTLYGCTFS
FLEHGLSRYG VEVTFVDMRD PENVRKAMRP NTKLVYIETP ANPNMYITDI DAVAKIAHSQ
EGVQVMVDNT YATPYLTRPL EHGADMVVHS ATKYLNGHGD VIAGFAVGKK EYIDQVRLLG
VKDLTGASMS PFDAWLINRG MKTLEVRMDR HCSNAQKVAE FLEQHPAVQN IAYPGLKSFP
QYDLAKRLMD QPGAMIAFEV KGGREAGITL MDSVQLCSLA VSLGDTETLI QHPASMTHSP
YTPEERAASD ISEGLVRLSV GLENPEDIIA DLKQGLDKLI
//