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Database: UniProt
Entry: A0A0A2FJ63_9PORP
LinkDB: A0A0A2FJ63_9PORP
Original site: A0A0A2FJ63_9PORP 
ID   A0A0A2FJ63_9PORP        Unreviewed;       400 AA.
AC   A0A0A2FJ63;
DT   04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT   04-FEB-2015, sequence version 1.
DT   24-JAN-2024, entry version 36.
DE   RecName: Full=L-methionine gamma-lyase {ECO:0000256|ARBA:ARBA00019040};
DE            EC=4.4.1.11 {ECO:0000256|ARBA:ARBA00012222};
GN   Name=mdeA {ECO:0000313|EMBL:SQH73377.1};
GN   ORFNames=HQ45_02695 {ECO:0000313|EMBL:KGN91028.1}, NCTC12858_01232
GN   {ECO:0000313|EMBL:SQH73377.1};
OS   Porphyromonas crevioricanis.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Porphyromonadaceae;
OC   Porphyromonas.
OX   NCBI_TaxID=393921 {ECO:0000313|EMBL:KGN91028.1, ECO:0000313|Proteomes:UP000030139};
RN   [1] {ECO:0000313|EMBL:KGN91028.1, ECO:0000313|Proteomes:UP000030139}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=COT-253 OH2125 {ECO:0000313|Proteomes:UP000030139}, and
RC   COT-253_OH2125 {ECO:0000313|EMBL:KGN91028.1};
RA   Wallis C., Deusch O., O'Flynn C., Davis I., Jospin G., Darling A.E.,
RA   Coil D.A., Alexiev A., Horsfall A., Kirkwood N., Harris S., Eisen J.A.;
RT   "Porphyromonas crevioricanis strain:COT-253_OH2125 Genome sequencing.";
RL   Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:SQH73377.1, ECO:0000313|Proteomes:UP000249300}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC12858 {ECO:0000313|EMBL:SQH73377.1,
RC   ECO:0000313|Proteomes:UP000249300};
RG   Pathogen Informatics;
RA   Doyle S.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + L-methionine = 2-oxobutanoate + methanethiol + NH4(+);
CC         Xref=Rhea:RHEA:23800, ChEBI:CHEBI:15377, ChEBI:CHEBI:16007,
CC         ChEBI:CHEBI:16763, ChEBI:CHEBI:28938, ChEBI:CHEBI:57844; EC=4.4.1.11;
CC         Evidence={ECO:0000256|ARBA:ARBA00000271};
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|RuleBase:RU362118};
CC   -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family. L-
CC       methionine gamma-lyase subfamily. {ECO:0000256|ARBA:ARBA00008667}.
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DR   EMBL; JQJB01000003; KGN91028.1; -; Genomic_DNA.
DR   EMBL; LS483447; SQH73377.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0A2FJ63; -.
DR   STRING; 393921.HQ45_02695; -.
DR   KEGG; pcre:NCTC12858_01232; -.
DR   eggNOG; COG0626; Bacteria.
DR   OrthoDB; 9803729at2; -.
DR   Proteomes; UP000030139; Unassembled WGS sequence.
DR   Proteomes; UP000249300; Chromosome 1.
DR   GO; GO:0018826; F:methionine gamma-lyase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR   CDD; cd00614; CGS_like; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR   InterPro; IPR006237; L-Met_gamma_lys.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   NCBIfam; TIGR01328; met_gam_lyase; 1.
DR   PANTHER; PTHR11808:SF80; GAMMA-CYSTATHIONASE; 1.
DR   PANTHER; PTHR11808; TRANS-SULFURATION ENZYME FAMILY MEMBER; 1.
DR   Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR   PIRSF; PIRSF001434; CGS; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR   PROSITE; PS00868; CYS_MET_METAB_PP; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:KGN91028.1};
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW   ECO:0000256|PIRSR:PIRSR001434-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000249300}.
FT   MOD_RES         213
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ   SEQUENCE   400 AA;  43662 MW;  A5691873779FC2B2 CRC64;
     MMKNEELKKS GFATRAIHAG SVENEFGTLA APIYQTSTFV FENAAQGGRR FALEEEGYIY
     TRLGNPTCTM VEEKLAMLEG GEAACSMSSG IGAISSAIWV LVKAGDHIVA GKTLYGCTFS
     FLEHGLSRYG VEVTFVDMRD PENVRKAMRP NTKLVYIETP ANPNMYITDI DAVAKIAHSQ
     EGVQVMVDNT YATPYLTRPL EHGADMVVHS ATKYLNGHGD VIAGFAVGKK EYIDQVRLLG
     VKDLTGASMS PFDAWLINRG MKTLEVRMDR HCSNAQKVAE FLEQHPAVQN IAYPGLKSFP
     QYDLAKRLMD QPGAMIAFEV KGGREAGITL MDSVQLCSLA VSLGDTETLI QHPASMTHSP
     YTPEERAASD ISEGLVRLSV GLENPEDIIA DLKQGLDKLI
//
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