ID A0A0A2J2P4_PENEN Unreviewed; 311 AA.
AC A0A0A2J2P4;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Dehydrogenase, multihelical {ECO:0000313|EMBL:KGO53518.1};
GN ORFNames=PEX2_061260 {ECO:0000313|EMBL:KGO53518.1};
OS Penicillium expansum (Blue mold rot fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=27334 {ECO:0000313|EMBL:KGO53518.1, ECO:0000313|Proteomes:UP000030143};
RN [1] {ECO:0000313|EMBL:KGO53518.1, ECO:0000313|Proteomes:UP000030143}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MD-8 {ECO:0000313|EMBL:KGO53518.1,
RC ECO:0000313|Proteomes:UP000030143};
RX PubMed=25338147; DOI=10.1094/MPMI-09-14-0261-FI;
RA Ballester A.R., Marcet-Houben M., Levin E., Sela N., Selma-Lazaro C.,
RA Carmona L., Wisniewski M., Droby S., Gonzalez-Candelas L., Gabaldon T.;
RT "Genome, transcriptome, and functional analyses of Penicillium expansum
RT provide new insights into secondary metabolism and pathogenicity.";
RL Mol. Plant Microbe Interact. 28:232-248(2015).
CC -!- SIMILARITY: Belongs to the HIBADH-related family. NP60 subfamily.
CC {ECO:0000256|ARBA:ARBA00007598}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGO53518.1}.
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DR EMBL; JQFZ01000250; KGO53518.1; -; Genomic_DNA.
DR RefSeq; XP_016596120.1; XM_016743397.1.
DR AlphaFoldDB; A0A0A2J2P4; -.
DR STRING; 27334.A0A0A2J2P4; -.
DR GeneID; 27678817; -.
DR HOGENOM; CLU_035117_5_0_1; -.
DR OrthoDB; 1332762at2759; -.
DR PhylomeDB; A0A0A2J2P4; -.
DR Proteomes; UP000030143; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43580; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR PANTHER; PTHR43580:SF2; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000030143}.
FT DOMAIN 3..164
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 175..293
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 177
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 311 AA; 32975 MW; 80058361A561A3C4 CRC64;
MPQIGWYGLG SMGLAMASNL QRHLATKKAL NLIYSNRTMS RGSPLPALGA IPEPNFEKLV
SQCEIIFTMV SNDAVLQSLL STAMGSGQSL KDKIFVDCST VHPDTVRSAV AQLKIKDASY
IAAPVFGGNP IAVDGKLVFA IGGPKSATEA VKPLIQDVMG RRVIDCGEDA TKSSLLKIAG
NIVTVNMMEA VGEAQVFAEK TGLGTGPMEE LISEAFGPVA GGYSKRLTTG AYAPPLDSRP
GFGVSLAIKD ARHAMSMAQE QGVELPGLEI ARANMEAARE YGGECLDSSA MYGTLRQKAG
LEFWNEKSRK E
//
