ID A0A0A2K312_PENEN Unreviewed; 2246 AA.
AC A0A0A2K312;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Carrier domain-containing protein {ECO:0000259|PROSITE:PS50075};
GN ORFNames=PEX2_013770 {ECO:0000313|EMBL:KGO62069.1};
OS Penicillium expansum (Blue mold rot fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=27334 {ECO:0000313|EMBL:KGO62069.1, ECO:0000313|Proteomes:UP000030143};
RN [1] {ECO:0000313|EMBL:KGO62069.1, ECO:0000313|Proteomes:UP000030143}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MD-8 {ECO:0000313|EMBL:KGO62069.1,
RC ECO:0000313|Proteomes:UP000030143};
RX PubMed=25338147; DOI=10.1094/MPMI-09-14-0261-FI;
RA Ballester A.R., Marcet-Houben M., Levin E., Sela N., Selma-Lazaro C.,
RA Carmona L., Wisniewski M., Droby S., Gonzalez-Candelas L., Gabaldon T.;
RT "Genome, transcriptome, and functional analyses of Penicillium expansum
RT provide new insights into secondary metabolism and pathogenicity.";
RL Mol. Plant Microbe Interact. 28:232-248(2015).
CC -!- SIMILARITY: Belongs to the NRP synthetase family.
CC {ECO:0000256|ARBA:ARBA00029454}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGO62069.1}.
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DR EMBL; JQFZ01000026; KGO62069.1; -; Genomic_DNA.
DR RefSeq; XP_016602721.1; XM_016738654.1.
DR STRING; 27334.A0A0A2K312; -.
DR GeneID; 27674073; -.
DR HOGENOM; CLU_000022_60_2_1; -.
DR OrthoDB; 1818010at2759; -.
DR Proteomes; UP000030143; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0018130; P:heterocycle biosynthetic process; IEA:UniProt.
DR GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR CDD; cd05918; A_NRPS_SidN3_like; 2.
DR CDD; cd19542; CT_NRPS-like; 1.
DR CDD; cd19545; FUM14_C_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR PANTHER; PTHR45527:SF3; SIDEROPHORE SYNTHETASE (EUROFUNG)-RELATED; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000030143}.
FT DOMAIN 616..692
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1726..1802
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1056..1082
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2246 AA; 246113 MW; 7D9DE1391A9BF802 CRC64;
MTAKTKQVNH SQRDVGYTLT MKKDIGTATQ EVTSDLEQLS NNEDGKAFQE REKGEISLLN
DADMLKLADW NRTMPTQVDW CVHHQITEQC QAQPNAPAVC AWDGNFTYGE IDQLSTALAV
QLAGYGVGPE MFVPLCFEKS CWTAVAILGV LKAGAAFALL DCNQPQSRLQ ELCDSVNATL
VLSSRDNKSR SQKLADTVIV LSRTMEFPGE SYDSSAISFA QPHNAVYASF TSGSTGKPKV
VVVEHSAYCS NVLAHSKELH FDKHSRVLQS ASYAFGASIM QIVTTLMVGG CVCVPSESEC
LDNIAAAARK LQVNWALFTP SALRTIQQED LSCLKHVVLV GEPPAREDIA VWADHTQVMK
GYGSAECSVC CAVAQDMKLL SNPQSIGRMA GGVSWVVDAD NHHKLVPLGV VGELIVEGPI
LARGYLNDTK KTTEAFIDPP SWFSEFCERY NKISRCGRRL YKTGDLVRYD ADGSLLFIGR
KDTQVKIRGQ RVELGEVEHH VRQGLAGNAG PQAVAEVVTP LGSDVPMLVA FIAIGEEANE
SPDHVRAALA KLTQGVEDWL MEHVPRYMVP SVYIAVDMIP MTATGKTDRR QLRELGGALT
LEQLAELQPS RSTLRVPTTA LEEQLHRLWT RVLKLPPNRI GVDDSFLRIG GDSITAVQLV
AAAREDGLSL TVADIFSTPR LSDMAHIVKI DSSVDEHIAP FSLLQPGIPV DLARTQVALQ
CKVDMGLVED IFPCTPLQEG MLSMNAKRAG AYISQNTLEL RGNVDIRRLE RAWQEVVAMT
PILRTRVVDL VGQGLVQVVV AGQAPFVTGQ NLRAYLQADK NETMGLGKPL ARFAIMDGPG
ALRPTFVWTA HHALFDGWSM PIIFKQLEQA YHGHTLDRLV PFQGFIKHIL QSGDDTMATE
EYWQSQLGGC EPMAFPSLPL PDYEPRADEG VQHYISQLQW PRSDITASTA IRAAWAILLA
QYTNSPDVIF GATVTGRHQT VPGIERIAAP TIATVPLRIR WSWEDGLQDL LQQVQTQASS
MTAYEQMGLQ RIRRISPSTE QACQFQTLLV VQPAARESET PPPDMLFEVP SQENDEDDES
ARKLSTSNTY ACMVECHLGE DSLQLRVNFD SRVIEKVQVQ RIAWHLEHLL REICVGRAMP
IAVGDLVGPS AKDHHQLQEW NGKMPAQVNR CVHALVAERC QAQPAAPAVC AWDGDLTYGE
LDVLSSALAA HLAERGVGPE VFVPVCFEKS RWTIVAMLGV MKAGGAFVLL DPSHPRARRQ
VICRAVSAEL VVASASQAAA AAELIAQVVV VGDNVTTWQT SGGWKRSSVT PDNSLYTIFT
SGSTGTPKGV VVPHAAFASG GFAHGRTDHL TAQSRVFQFS SYAFDVSIID ILTALIVGSC
ICVPSEASRR DDITKAASQL RVTWAQLTPS TAKLLRREDI PTLQTLVLAG EAVTLRDIEP
WIGHVKLVNG YGPAECSGLS SIHPGLGRSD ANNIGWAPSS VFWIVNRDNH EQLVPIGAVG
ELLIEGPIVG RGYLNNPVKT AEAFINLPAW LQEFRRKSNP QAAADYPTIN RLYKTGDLVR
YAADGSMRYL GRKDTQVKLR GQRIEVGEVE YHTRECFPGA RDVVVEVVTP AEAKRPPMLV
AFVWTDDING AKSSDTKRDD NERAEHKADE LLASPTDAFR AIIPRVEAGL HDAVPSYMVP
AVFLPLVAIP LTATGKTDRR RLRERAATLT RAEMEAYSSP AMAKRAPATA AERTLQQLWA
RVLHLAPDSI GADDSFFRVG GDSISAMYLV GLARGQGFEL SVSQVFALRQ LSVLAKALIK
SQIVDTSKSI DPFSLLDPQQ KSVILHSRPS GLSLTNDAVL DIIPVTDSQV FFLTQWSLSC
FSYSIQGMVD ADRLRLACHS LVQAHAIMRT VFIKHQGKLL QVVLKSINLP FDHIHTEKPL
EPIWRSLCEI DSKEESVSGK PLVKFTLISR SQTEHIFTVR LSHAQYDGAS KPMILTDLVA
AYNEDIQSGP VCATFPDYVY YCASNGSDTA FEFWKDCLQG SAMTMLPCLD LRGETLTDIH
ETAFGDLPSA FEDITIPILV NAAFSFILSN LTQKDDVVFG VVMNTRTIPL PQVQTILGPC
INLNPLRAPI AQVSTVYDLC RLLRDQYTQS VQFSHLDFSD IRAKSTDWPL DTKLGCIVNH
LGGAENSPLT LGARANISDS LVMSRINLED QLLIRSIPGD GKLQVQVLTS NKIMVSEQAG
LLAKRLIETV NVFARSPEAL LSSMCS
//
