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Database: UniProt
Entry: A0A0A2KJQ8_PENEN
LinkDB: A0A0A2KJQ8_PENEN
Original site: A0A0A2KJQ8_PENEN 
ID   A0A0A2KJQ8_PENEN        Unreviewed;       494 AA.
AC   A0A0A2KJQ8;
DT   04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT   04-FEB-2015, sequence version 1.
DT   16-JAN-2019, entry version 25.
DE   SubName: Full=Peptidase S8/S53, subtilisin/kexin/sedolisin {ECO:0000313|EMBL:KGO52900.1};
GN   ORFNames=PEX2_047990 {ECO:0000313|EMBL:KGO52900.1};
OS   Penicillium expansum (Blue mold rot fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=27334 {ECO:0000313|EMBL:KGO52900.1, ECO:0000313|Proteomes:UP000030143};
RN   [1] {ECO:0000313|EMBL:KGO52900.1, ECO:0000313|Proteomes:UP000030143}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MD-8 {ECO:0000313|EMBL:KGO52900.1,
RC   ECO:0000313|Proteomes:UP000030143};
RX   PubMed=25338147; DOI=10.1094/MPMI-09-14-0261-FI;
RA   Ballester A.R., Marcet-Houben M., Levin E., Sela N., Selma-Lazaro C.,
RA   Carmona L., Wisniewski M., Droby S., Gonzalez-Candelas L.,
RA   Gabaldon T.;
RT   "Genome, transcriptome, and functional analyses of Penicillium
RT   expansum provide new insights into secondary metabolism and
RT   pathogenicity.";
RL   Mol. Plant Microbe Interact. 28:232-248(2015).
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|PROSITE-ProRule:PRU01032};
CC       Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000256|PROSITE-
CC       ProRule:PRU01032};
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KGO52900.1}.
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DR   EMBL; JQFZ01000258; KGO52900.1; -; Genomic_DNA.
DR   RefSeq; XP_016595596.1; XM_016742074.1.
DR   EnsemblFungi; KGO48369; KGO48369; PEXP_041700.
DR   EnsemblFungi; KGO52900; KGO52900; PEX2_047990.
DR   EnsemblFungi; KGO68039; KGO68039; PEX1_097100.
DR   GeneID; 27677493; -.
DR   OrthoDB; 1294880at2759; -.
DR   PhylomeDB; A0A0A2KJQ8; -.
DR   Proteomes; UP000030143; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   CDD; cd04056; Peptidases_S53; 1.
DR   CDD; cd11377; Pro-peptidase_S53; 1.
DR   Gene3D; 3.40.50.200; -; 1.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015366; S53_propep.
DR   InterPro; IPR030400; Sedolisin_dom.
DR   Pfam; PF09286; Pro-kuma_activ; 1.
DR   SMART; SM00944; Pro-kuma_activ; 1.
DR   SUPFAM; SSF52743; SSF52743; 1.
DR   PROSITE; PS51695; SEDOLISIN; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Complete proteome {ECO:0000313|Proteomes:UP000030143};
KW   Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Protease {ECO:0000256|PROSITE-ProRule:PRU01032};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030143};
KW   Serine protease {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   DOMAIN      108    491       Peptidase S53. {ECO:0000259|PROSITE:
FT                                PS51695}.
FT   ACT_SITE    184    184       Charge relay system.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   ACT_SITE    188    188       Charge relay system.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   ACT_SITE    399    399       Charge relay system.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   METAL       441    441       Calcium. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01032}.
FT   METAL       442    442       Calcium; via carbonyl oxygen.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   METAL       469    469       Calcium; via carbonyl oxygen.
FT                                {ECO:0000256|PROSITE-ProRule:PRU01032}.
FT   METAL       471    471       Calcium. {ECO:0000256|PROSITE-ProRule:
FT                                PRU01032}.
SQ   SEQUENCE   494 AA;  53860 MW;  08953F29E6893C54 CRC64;
     MKRDEVKQFL SPSPAISDRI IAWLRSESVP ASSINLDGHW ISFTVPICRA EQMLKTEFFN
     FHQQDPQSIA IRTLGYSVPR ALHAHIQLIQ PTTRFATSEQ RAAGCDTTVI PDCIQGLYGI
     DNTTTRPEWR NRLGISGFLE QYARHADFDE FLRLYASGHT DANFSVVSIN GGQDDQHSIS
     DSVEANLDVQ YSIPLADEVL ATFYSTGGRG PVVPEINHPD PTESSNEPYL EQLHYLLNLP
     DEELPAVLSN SYGENEQSLP PSYLNATCSL FAQLGARGVS ILFGSGDSGP GSICVRNDGS
     NQTRFLPGYP ASCPFVTAVG GTYGINPEKA VSFSGGGFSE VFPRPRYQDQ AVKGYLRHLG
     RRWNGLYNAT GRGYPDVSAQ AANFIVRDHS EWISVGGTSA STPVIAAVIS RLNSARIAQG
     KPRMGFLNPW LYGHGHTGLK DIVLGSSTGC RRSLGDPRVR NASWDATEGW DPVTGLGTPL
     FPTLVKLALS DDHA
//
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