ID A0A0A2LB28_PENIT Unreviewed; 861 AA.
AC A0A0A2LB28;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Peptidase M28 {ECO:0000313|EMBL:KGO76408.1};
GN ORFNames=PITC_072900 {ECO:0000313|EMBL:KGO76408.1};
OS Penicillium italicum (Blue mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=40296 {ECO:0000313|EMBL:KGO76408.1, ECO:0000313|Proteomes:UP000030104};
RN [1] {ECO:0000313|EMBL:KGO76408.1, ECO:0000313|Proteomes:UP000030104}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PHI-1 {ECO:0000313|EMBL:KGO76408.1,
RC ECO:0000313|Proteomes:UP000030104};
RX PubMed=25338147; DOI=10.1094/MPMI-09-14-0261-FI;
RA Ballester A.R., Marcet-Houben M., Levin E., Sela N., Selma-Lazaro C.,
RA Carmona L., Wisniewski M., Droby S., Gonzalez-Candelas L., Gabaldon T.;
RT "Genome, transcriptome, and functional analyses of Penicillium expansum
RT provide new insights into secondary metabolism and pathogenicity.";
RL Mol. Plant Microbe Interact. 28:232-248(2015).
CC -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC {ECO:0000256|ARBA:ARBA00005634}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGO76408.1}.
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DR EMBL; JQGA01000261; KGO76408.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0A2LB28; -.
DR STRING; 40296.A0A0A2LB28; -.
DR HOGENOM; CLU_005688_2_0_1; -.
DR OMA; LWNVIGT; -.
DR OrthoDB; 67337at2759; -.
DR PhylomeDB; A0A0A2LB28; -.
DR Proteomes; UP000030104; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08022; M28_PSMA_like; 1.
DR CDD; cd02121; PA_GCPII_like; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 1.20.930.40; Transferrin receptor-like, dimerisation domain; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR039373; Peptidase_M28B.
DR InterPro; IPR007365; TFR-like_dimer_dom.
DR InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR InterPro; IPR005349; TMEM14.
DR PANTHER; PTHR10404:SF46; GLUTAMATE CARBOXYPEPTIDASE 2 HOMOLOG; 1.
DR PANTHER; PTHR10404; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR Pfam; PF04253; TFR_dimer; 1.
DR Pfam; PF03647; Tmemb_14; 1.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF47672; Transferrin receptor-like dimerisation domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000030104};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 34..56
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 836..856
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 203..280
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT DOMAIN 396..583
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
FT DOMAIN 647..756
FT /note="Transferrin receptor-like dimerisation"
FT /evidence="ECO:0000259|Pfam:PF04253"
SQ SEQUENCE 861 AA; 94213 MW; EC992F9E74F40235 CRC64;
MREKDMRYSE TTPLLEVNVA PPRHRYPHHA IRRACTISLA ALLSVATLLF LLPTAILPRE
GGSIWSYLPG AHPIPHEAWP ESYGLPYEQL QQILLNVPSA AKAREWSQYY TAGPHLAGKN
LSQALWTLEK WKEFGVEDTG LATYDIYINY PLEHRLALLK TSGDKTEVTF EATLEEDILE
EDPTSGLPDR VPSFHGYSAT GNVTAQFVYV NFGTYKDFED LVNANITLEG KIAIAKYGGI
FRGLKVKRAQ ELGMVGVVIY SDPQEDGEIT EENGYEAYPN GPARNPSAIQ RGSTQFLSIL
PGDPTTPGYA SKPGCERQDP HNSIPSIPSL PVSYKEVLPF LKALNGHGPK ASDFNESWQG
GGLGYKGVEY NIGPSPEDVV INLHNLQEYV TTPLWNVIGT IKGHISDEVV VLGNHRDAWI
AGGAGDPNSG SAALNEVVRS FGEALKAGWK PLRTVVFASW DGEEYGLLGS TEWVEEHLPW
LSKANIAYLN VDVAAAGTNF EPRASPLLNK VINDVTALVQ SPNQTVRGQT IRDVWDGKIS
TMGSGSDFTA FQDFAGIASL DFGFGRGKND PVYHYHSNYD SFAWMEKYGD KEFLYHQACT
KLWALAAAQL VESPLLALNA TDYSLGLGSY LDHIKPAADN LPEGTHFDFA PLDRAIFEFQ
ESAKAFDAHA ADLKSQLGDD VPWYHWWKKV RLLFQIRITN AKYKGIERAF LYQPGLDGRE
WFKHVVFAPG IWTGYSGATY PGLVESFEAG DVENAEAPTT SALALSLLTS IGGIIGYART
GSLPSIIAGV SVGLVYLLSF LRLRAGQSYG EELGLLASAV LGGSSVPRVI KTGGKPVPLV
LSVLATYGLF VFGIAFREKR A
//
