ID A0A0A2LC15_PENIT Unreviewed; 1063 AA.
AC A0A0A2LC15;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE RecName: Full=Protein HIR {ECO:0000256|RuleBase:RU364014};
GN ORFNames=PITC_022030 {ECO:0000313|EMBL:KGO74145.1};
OS Penicillium italicum (Blue mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX NCBI_TaxID=40296 {ECO:0000313|EMBL:KGO74145.1, ECO:0000313|Proteomes:UP000030104};
RN [1] {ECO:0000313|EMBL:KGO74145.1, ECO:0000313|Proteomes:UP000030104}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PHI-1 {ECO:0000313|EMBL:KGO74145.1,
RC ECO:0000313|Proteomes:UP000030104};
RX PubMed=25338147; DOI=10.1094/MPMI-09-14-0261-FI;
RA Ballester A.R., Marcet-Houben M., Levin E., Sela N., Selma-Lazaro C.,
RA Carmona L., Wisniewski M., Droby S., Gonzalez-Candelas L., Gabaldon T.;
RT "Genome, transcriptome, and functional analyses of Penicillium expansum
RT provide new insights into secondary metabolism and pathogenicity.";
RL Mol. Plant Microbe Interact. 28:232-248(2015).
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000256|ARBA:ARBA00002677,
CC ECO:0000256|RuleBase:RU364014}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364014}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family.
CC {ECO:0000256|ARBA:ARBA00007306, ECO:0000256|RuleBase:RU364014}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGO74145.1}.
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DR EMBL; JQGA01000706; KGO74145.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0A2LC15; -.
DR STRING; 40296.A0A0A2LC15; -.
DR HOGENOM; CLU_004372_3_1_1; -.
DR OMA; RGSWDGD; -.
DR OrthoDB; 5478541at2759; -.
DR PhylomeDB; A0A0A2LC15; -.
DR Proteomes; UP000030104; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR031120; HIR1-like.
DR InterPro; IPR011494; HIRA-like_C.
DR InterPro; IPR019015; HIRA_B_motif.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13831; MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS; 1.
DR PANTHER; PTHR13831:SF0; PROTEIN HIRA; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF09453; HIRA_B; 1.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF101908; Putative isomerase YbhE; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853,
KW ECO:0000256|RuleBase:RU364014}; Nucleus {ECO:0000256|RuleBase:RU364014};
KW Reference proteome {ECO:0000313|Proteomes:UP000030104};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364014};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364014};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364014};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364014};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 20..45
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 67..108
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 128..169
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 170..211
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 746..980
FT /note="Protein HIRA-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07569"
FT REGION 422..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 652..675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..478
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 660..675
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1063 AA; 115102 MW; D43BFD1F8A53EDB6 CRC64;
MHIIKPVWLT HGGERKDFEV YSCDVSPDGK RLVTAAGDGY VRIWSTDAIY GTGTPELEGK
PKQLASMSNH SGTIHTVRFS PNGKYLASGA DDKIVCVYTL DANPPTHSST FGTDEAPPVE
NWRTIRRLIG HDNDVQDLGW SFDSSILVSV GLDSKVVVWS GHSFEKLKTI AIHQSHVKGI
TFDPANKYFA TASDDRTVRI FRFTSPAPNS SAHDHMNNFV LEQTITAPFA NSPLTAYFRR
CSWSPDGMHI AAANAVNGPV SSVAIINRGS WDGDINLIGH EAPVEVCSFS PRLYATEPPG
KKQADGQPVP QHHITVIACA GGDKSLSIWI TSNARPIVVA QEMAAKAISD LAWTPDGKCL
FATALDGTIV AVRFEDGELG WATEMEENEK SLTKFGTNRR GAGITETTDS LLLEEKSKAG
EIKHVEGRMG ALMGDSAETT TNGDKAPQPS NGTTPARGSS PAPEPTKTQT NGTPSTPAAT
EAEKPDPYKA KLERLKQRPT YTKEGKKRIA PLLVSGAGAG ESSLPQARLM ASVSNQVKAD
APTTIVDLSK PFDGLPKGGL TALLLGNKRK LAQIEGDEDG SVEKRVTLAS QNGATPIMAN
TPDGLLPAQV QSATIGQQPT PEFIRPAVTN PCMSVSQLRL AVPKIRSQIL RALDSSGKPT
EQPAPGTDSS STKSRVDVVF EARNPSPASL TGRVVDREPV RLTLFRGDQP LWQDFLPRTV
LLVTGNQSMW AAACEDGSIY LWTPAGRRLV SALVLEAQPV ILECNGPWIM CISSVGMCYV
WNVKHLSSPH PPVSLQPVLD AAIHTMGANP TAAPAVTDAR INSEGRVIVS LSNGEGYSYS
PSMFTWQRIS EAWWAVGSQY WNTTDAPVSN LQAKDAQQDN KDAKAAVAAG IIPWLERNTT
NETLLRGRAY FLQRLIKVLL SREGYETFES SVSIAHLENR LAAALSLGAK EEFRLYLSMY
AKRIGAEGLK LKVEELLKGL IGGLFEDEDD ASEGVLKLQA NEREGRNWRE GSDDLCGWPR
ETLLKEVILA LGKHRDLQRV TVPYAKLLDM VDTTSEHGDA MDL
//
