ID   A0A0A2LFP7_9FLAO        Unreviewed;       584 AA.
AC   A0A0A2LFP7;
DT   04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT   04-FEB-2015, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   SubName: Full=Phenylalanine 4-monooxygenase {ECO:0000313|EMBL:KGO78992.1};
GN   ORFNames=Q763_15885 {ECO:0000313|EMBL:KGO78992.1};
OS   Flavobacterium beibuense F44-8.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Flavobacterium.
OX   NCBI_TaxID=1406840 {ECO:0000313|EMBL:KGO78992.1, ECO:0000313|Proteomes:UP000030129};
RN   [1] {ECO:0000313|EMBL:KGO78992.1, ECO:0000313|Proteomes:UP000030129}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F44-8 {ECO:0000313|EMBL:KGO78992.1,
RC   ECO:0000313|Proteomes:UP000030129};
RA   Zeng Z., Chen C.;
RL   Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000256|ARBA:ARBA00001954,
CC         ECO:0000256|PIRSR:PIRSR601273-2};
CC   -!- SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid
CC       hydroxylase family. {ECO:0000256|ARBA:ARBA00009712}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KGO78992.1}.
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DR   EMBL; JRLV01000023; KGO78992.1; -; Genomic_DNA.
DR   RefSeq; WP_035135950.1; NZ_JRLV01000023.1.
DR   AlphaFoldDB; A0A0A2LFP7; -.
DR   STRING; 1406840.Q763_15885; -.
DR   eggNOG; COG3186; Bacteria.
DR   Proteomes; UP000030129; Unassembled WGS sequence.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0016714; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen; IEA:InterPro.
DR   GO; GO:0009072; P:aromatic amino acid metabolic process; IEA:InterPro.
DR   CDD; cd00361; arom_aa_hydroxylase; 1.
DR   Gene3D; 1.20.58.690; -; 1.
DR   Gene3D; 1.10.800.10; Aromatic amino acid hydroxylase; 1.
DR   InterPro; IPR001273; ArAA_hydroxylase.
DR   InterPro; IPR036951; ArAA_hydroxylase_sf.
DR   InterPro; IPR036329; Aro-AA_hydroxylase_C_sf.
DR   InterPro; IPR019774; Aromatic-AA_hydroxylase_C.
DR   PANTHER; PTHR11473; AROMATIC AMINO ACID HYDROXYLASE; 1.
DR   PANTHER; PTHR11473:SF24; PHENYLALANINE-4-HYDROXYLASE; 1.
DR   Pfam; PF00351; Biopterin_H; 2.
DR   SUPFAM; SSF56534; Aromatic aminoacid monoxygenases, catalytic and oligomerization domains; 1.
DR   PROSITE; PS51410; BH4_AAA_HYDROXYL_2; 1.
PE   3: Inferred from homology;
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR601273-2};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|PIRSR:PIRSR601273-2};
KW   Monooxygenase {ECO:0000256|ARBA:ARBA00023033, ECO:0000313|EMBL:KGO78992.1};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030129}.
FT   DOMAIN          1..259
FT                   /note="Biopterin-dependent aromatic amino acid hydroxylase
FT                   family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS51410"
FT   BINDING         131
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT   BINDING         136
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
FT   BINDING         221
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601273-2"
SQ   SEQUENCE   584 AA;  64935 MW;  E2FC6B57A9759B00 CRC64;
     MNATIESNPL IDRLPKHLKQ FIKPQDYEEY TPINQAVWRY VMRKNVDYLS KVAHSSYLDG
     LKKTGIEVDS IPSMYGMNRI LKEIGWAAVA VDGFIPPNAF MEFQAYNVLV IASDIRQLEH
     IEYTPAPDII HEGAGHAPII ANPEYAEYLR RFGEIGCKAI SSARDYEIYE AIRLLSILKE
     AEGTPQDEIE AAEKRVDELQ NDLGELSEMA LIRNLHWWTV EYGLIGTVED PKIYGAGLLS
     SIGESAWCMT DNVTKLPYDI NAAYQSFDIT KPQPQLFVTP DFAHLSLVLE EFANKMALRT
     GGLSGVQKLI NSNALGTVEL STGVQISGVF SNVIENEGKP IYLQCTGGTA LAYREKELVG
     HGTSYHAEGF GSPVGKLKGI NLAIEDMSPR DLKAYGVYEG ERVTLEFEGD VTVNGEIITG
     TRNIQGKIIL ISFKDCTVTH GDTVLFQPEW GTYDMAVGKK VVSAFSGPAD VNSFDLITHV
     PSSQTIKAKK SVERQELEGL YQNVRDIRSG ATGDLEAIFT KVKESHPNDW LLSVEIAELL
     HKNKQEELLN KVVLHLDEVK KKRPEVAHLV DGGLELIFEK EKIS
//