ID   A0A0A2M011_9FLAO        Unreviewed;       630 AA.
AC   A0A0A2M011;
DT   04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT   04-FEB-2015, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   SubName: Full=Peptidase M1 {ECO:0000313|EMBL:KGO84803.1};
GN   ORFNames=Q765_19665 {ECO:0000313|EMBL:KGO84803.1};
OS   Flavobacterium rivuli WB 3.3-2 = DSM 21788.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Flavobacterium.
OX   NCBI_TaxID=1121895 {ECO:0000313|EMBL:KGO84803.1, ECO:0000313|Proteomes:UP000030152};
RN   [1] {ECO:0000313|EMBL:KGO84803.1, ECO:0000313|Proteomes:UP000030152}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WB 3.3-2 {ECO:0000313|EMBL:KGO84803.1,
RC   ECO:0000313|Proteomes:UP000030152};
RA   Zeng Z., Chen C.;
RL   Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|PIRSR:PIRSR634015-3};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRSR:PIRSR634015-3};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KGO84803.1}.
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DR   EMBL; JRLX01000036; KGO84803.1; -; Genomic_DNA.
DR   RefSeq; WP_020213905.1; NZ_KB899971.1.
DR   AlphaFoldDB; A0A0A2M011; -.
DR   STRING; 1121895.GCA_000378485_02737; -.
DR   eggNOG; COG0308; Bacteria.
DR   OrthoDB; 9814383at2; -.
DR   Proteomes; UP000030152; Unassembled WGS sequence.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd09604; M1_APN_like; 1.
DR   Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR   InterPro; IPR034015; M1_LTA4H.
DR   InterPro; IPR014782; Peptidase_M1_dom.
DR   InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR   PANTHER; PTHR45726; LEUKOTRIENE A-4 HYDROLASE; 1.
DR   PANTHER; PTHR45726:SF3; LEUKOTRIENE A-4 HYDROLASE; 1.
DR   Pfam; PF01433; Peptidase_M1; 1.
DR   SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR634015-3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030152};
KW   Signal {ECO:0000256|SAM:SignalP}; Zinc {ECO:0000256|PIRSR:PIRSR634015-3}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..630
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5001991481"
FT   DOMAIN          360..514
FT                   /note="Peptidase M1 membrane alanine aminopeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF01433"
FT   ACT_SITE        367
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR634015-1"
FT   ACT_SITE        455
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR634015-1"
FT   BINDING         366
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR634015-3"
FT   BINDING         370
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR634015-3"
FT   BINDING         389
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR634015-3"
SQ   SEQUENCE   630 AA;  71440 MW;  EE93D10747845EE8 CRC64;
     MRTILAVALL SASGLFAQKS PNAGYWQQHV NYKMDVSVDV KTFKYTGKQQ LVYTNNSPDT
     LRRVFYHLYN NAFQPNSEMD ARLQAIADPD SRMVITTKVG DKTTKTSRIA PLKPNETGYL
     NITNFKQDNV AAKTIVSGTI LEVTLAKPIL PHSSTTFTLD FDAQVPLQIR RSGRNSADGI
     ALSMTQWYPK MAEYDFEGWH ADPYIGREFH GVWGDFDVNI TIDKTYTIGG SGYLQNKNEI
     GKGYEDAGVT VEIPKKAKTL TWHFFAPNVH DFAWGADPEY IHDKIIGENS VELHFFYKNK
     PEFLDNWKRL QPKTAEILAY YDKNVGPYPY KQYSVVQGGD GGMEYAMCTL ITGGRSFGSL
     VGTTAHEFAH SWFQHILATN ESKHYWMDEG FTSYISDLAM DAVLPPKVKE DEAPESPFKG
     AYDNYFYLVK SGKEQPLTTH ADRYNSNTAY SIAAYSKGEI FLAQLGYVIG EEKLAQTLKR
     YFADYKFTHP TPNDIKRTAE KVSGAELDWY LTDWCQTTNT IDYSIKEVKE AGANTTITLE
     RIGLMPMPID IIVAYSDGTQ ESFYVPLNLM HYTKDNPFPK LKRTVLKEWD WAHPTFTFTI
     NKPKDAIRIM AIDPSETMAD VNKANNLYSK
//