ID A0A0A2MPC6_9FLAO Unreviewed; 504 AA.
AC A0A0A2MPC6;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=Probable malate:quinone oxidoreductase {ECO:0000256|HAMAP-Rule:MF_00212};
DE EC=1.1.5.4 {ECO:0000256|HAMAP-Rule:MF_00212};
DE AltName: Full=MQO {ECO:0000256|HAMAP-Rule:MF_00212};
DE AltName: Full=Malate dehydrogenase [quinone] {ECO:0000256|HAMAP-Rule:MF_00212};
GN Name=mqo {ECO:0000256|HAMAP-Rule:MF_00212};
GN ORFNames=Q764_03340 {ECO:0000313|EMBL:KGO90115.1};
OS Flavobacterium suncheonense GH29-5 = DSM 17707.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Flavobacterium.
OX NCBI_TaxID=1121899 {ECO:0000313|EMBL:KGO90115.1, ECO:0000313|Proteomes:UP000030121};
RN [1] {ECO:0000313|EMBL:KGO90115.1, ECO:0000313|Proteomes:UP000030121}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GH29-5 {ECO:0000313|EMBL:KGO90115.1,
RC ECO:0000313|Proteomes:UP000030121};
RA Zeng Z., Chen C.;
RL Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001139, ECO:0000256|HAMAP-
CC Rule:MF_00212};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|HAMAP-Rule:MF_00212};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC oxaloacetate from (S)-malate (quinone route): step 1/1.
CC {ECO:0000256|ARBA:ARBA00005012, ECO:0000256|HAMAP-Rule:MF_00212}.
CC -!- SIMILARITY: Belongs to the MQO family. {ECO:0000256|HAMAP-
CC Rule:MF_00212}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGO90115.1}.
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DR EMBL; JRLW01000003; KGO90115.1; -; Genomic_DNA.
DR RefSeq; WP_026981098.1; NZ_KE387020.1.
DR AlphaFoldDB; A0A0A2MPC6; -.
DR STRING; 1121899.GCA_000430025_00052; -.
DR eggNOG; COG0579; Bacteria.
DR OrthoDB; 9763983at2; -.
DR UniPathway; UPA00223; UER01008.
DR Proteomes; UP000030121; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR HAMAP; MF_00212; MQO; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006231; MQO.
DR NCBIfam; TIGR01320; mal_quin_oxido; 1.
DR PANTHER; PTHR43104; L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43104:SF2; L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR Pfam; PF06039; Mqo; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|HAMAP-Rule:MF_00212};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630, ECO:0000256|HAMAP-
KW Rule:MF_00212}; Membrane {ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002, ECO:0000256|HAMAP-
KW Rule:MF_00212}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Tricarboxylic acid cycle {ECO:0000256|HAMAP-Rule:MF_00212}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 504 AA; 55900 MW; 1E4D0644D3F5702D CRC64;
MTTKTTTQKS EADVVLIGAG IMSATLGLLL KELQPNLKIE IFERLDVAAA ESSDAWNNAG
TGHAAFCELN YTPEKPDGSI DTTKAVKIVE AFEVSRQFWA YLVEKGLLKN PESFIKHVPH
MSFVWGEKNT KYLKKRYDAL QQFHLFKEME YSEDPQTIKE WAPLIMEGRK GAKKVAATTM
KYGTDVNFGA LTRSIFKYLE TLDGVTLHFN HEVKKLRRYD DGTWRVRVKD LETGGKKRVK
TKFVFIGAGG GSLLLLEKAG IPEGEGYGGF PVSGQWLKCT NEELIAKHQV KVYGKAAVGA
PPMSVPHIDT RMIDGKKALL FGPYAGFSTK FLKNGSYLDL AKSIQLDNIK PMLSAGINNI
PLTKYLIEQV FQSSEDRMKA LREYLPDAKP EDWTLENAGQ RVQVIKKDKN GKGVLEFGTE
VVNCADGSLA VLLGASPGAS TAVSIMLDLL SRCFKDELAT PEWQAKLKEM IPSYGQSLNA
NPQLADEIRY RTGTVLKLRD VATV
//
