ID   A0A0A2V1D9_PARBA        Unreviewed;       694 AA.
AC   A0A0A2V1D9;
DT   04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT   04-FEB-2015, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   RecName: Full=MI domain-containing protein {ECO:0000259|PROSITE:PS51366};
GN   ORFNames=PAAG_11587 {ECO:0000313|EMBL:KGQ01606.1};
OS   Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) (Paracoccidioides
OS   brasiliensis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX   NCBI_TaxID=502779 {ECO:0000313|EMBL:KGQ01606.1, ECO:0000313|Proteomes:UP000002059};
RN   [1] {ECO:0000313|EMBL:KGQ01606.1, ECO:0000313|Proteomes:UP000002059}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-826 / Pb01 {ECO:0000313|Proteomes:UP000002059};
RX   PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA   Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA   Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA   Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA   Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA   Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA   Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA   Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA   Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT   "Comparative genomic analysis of human fungal pathogens causing
RT   paracoccidioidomycosis.";
RL   PLoS Genet. 7:E1002345-E1002345(2011).
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000256|ARBA:ARBA00004604}.
CC   -!- SIMILARITY: Belongs to the CWC22 family.
CC       {ECO:0000256|ARBA:ARBA00006856}.
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DR   EMBL; KN293998; KGQ01606.1; -; Genomic_DNA.
DR   RefSeq; XP_002794807.2; XM_002794761.2.
DR   AlphaFoldDB; A0A0A2V1D9; -.
DR   STRING; 502779.A0A0A2V1D9; -.
DR   GeneID; 9098313; -.
DR   KEGG; pbl:PAAG_11587; -.
DR   VEuPathDB; FungiDB:PAAG_11587; -.
DR   eggNOG; KOG2141; Eukaryota.
DR   HOGENOM; CLU_006786_2_1_1; -.
DR   OMA; FMVDILN; -.
DR   OrthoDB; 5491616at2759; -.
DR   Proteomes; UP000002059; Partially assembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   Gene3D; 1.25.40.180; -; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR003891; Initiation_fac_eIF4g_MI.
DR   InterPro; IPR003890; MIF4G-like_typ-3.
DR   PANTHER; PTHR18034; CELL CYCLE CONTROL PROTEIN CWF22-RELATED; 1.
DR   PANTHER; PTHR18034:SF4; NUCLEOLAR MIF4G DOMAIN-CONTAINING PROTEIN 1; 1.
DR   Pfam; PF02847; MA3; 1.
DR   Pfam; PF02854; MIF4G; 1.
DR   SMART; SM00544; MA3; 1.
DR   SMART; SM00543; MIF4G; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS51366; MI; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002059}.
FT   DOMAIN          438..576
FT                   /note="MI"
FT                   /evidence="ECO:0000259|PROSITE:PS51366"
FT   REGION          1..101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          602..627
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        27..56
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        76..90
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   694 AA;  77002 MW;  4142B5CCE57A4C14 CRC64;
     MKAQAAARKN KKSMGVESGR EREGSEESDE FGEEDEFDGF DDDDDDDGDS VSNDSGQDDE
     DTTQKPKKRE NPYLPPVSTP AAPPKYIPPS LRNQPSNESE SLTRLRRQAQ GHLNKLSEAN
     LLSILREIEK LYQDYPRRNV TSTLIELLMG LVYDRSVLQD TFIILHAGFI AAVYKVMGMD
     FGAELVEAVV RRFDGDYEVA RVKGREEKES DGGGNNNKEM LNAISLLSHL YSFHVIGCSL
     IFDYIRLFLT EITELNTELL LRIIKNSGPQ LRADSPSTLK DIILLLQPTL STLDPNTLSV
     RTKFMLETIT DLKNNRLKSN AASASSLSST HITTMRKILG SLNDSPRTLR ASEPIRIGRT
     DIHQADKRGK WWLVGASWRR DDAANQHNGQ QDTTDAGAAN AHAHAATALA DTLNDNDGIG
     GKEVDLLQLA RAHGMNTDVR RSIFVAIMSA ADYRDAHMRL AKLRLKRNQE GEIPRVLLHC
     AMEEEAHNPY YTLIARRLCG ERRMKMAFMF SLWDVFKRMG EGGVYGDDDG SGGGGGGGGE
     GDNEVTSKAI VNLAKMYGSL IAGGEMGLGA LKVLDFVYMQ SKTRVFVEVL IVAVMAQTQQ
     RRTRELQRER DGSGSRKGRD GGEGEEGFDE KALADVFLRT RETPQVVPRL IYFIRKVVAK
     TDIVVSKRER RIVKWGCKVA LDTLKAVSRA GGDG
//