ID A0A0A2W1K1_BEABA Unreviewed; 2522 AA.
AC A0A0A2W1K1;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Lovastatin nonaketide synthase {ECO:0000313|EMBL:KGQ06859.1};
GN ORFNames=BBAD15_g7827 {ECO:0000313|EMBL:KGQ06859.1};
OS Beauveria bassiana D1-5.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Cordycipitaceae; Beauveria.
OX NCBI_TaxID=1245745 {ECO:0000313|EMBL:KGQ06859.1, ECO:0000313|Proteomes:UP000030106};
RN [1] {ECO:0000313|EMBL:KGQ06859.1, ECO:0000313|Proteomes:UP000030106}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=D1-5 {ECO:0000313|EMBL:KGQ06859.1,
RC ECO:0000313|Proteomes:UP000030106};
RA Li Q., Wang L., Zhang Z., Wang Q., Ren J., Wang M., Xu W., Wang J., Lu Y.,
RA Du Q., Sun Z.;
RT "Genome sequencing and analysis of entomopathogenic fungi Beauveria
RT bassiana D1-5.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Secondary metabolite biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005179}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGQ06859.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ANFO01000748; KGQ06859.1; -; Genomic_DNA.
DR STRING; 1245745.A0A0A2W1K1; -.
DR eggNOG; KOG1202; Eukaryota.
DR HOGENOM; CLU_000022_31_0_1; -.
DR Proteomes; UP000030106; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd05195; enoyl_red; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775:SF29; ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF13602; ADH_zinc_N_2; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000030106};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 28..449
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2437..2515
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2522 AA; 274711 MW; D778BCFC146E428B CRC64;
MPDTDTSPSS WEEMECGATC SELSSTPPEP IAVIGMSCRL SGSAQDPCSL WEMLTSGRTA
WTPGPGNRFN MKAFQNPSAD KFGMTNTCGG HFLKEDVAAF DAAFFGIHAV EAKAIDPQHR
LLLEIAYECF ENAGFSIDSL WGSNTGVYVG QWANDYHEIQ TRDIDAPPLY LTTGTGPAIS
SNRISYFFNL RGPSFTVDTG CSSGLVALHQ AVQSLRSGET SQCFVGGVNL MLDPQRFVYQ
SKLKMFSKEG RSFAFDSRAN GYGRGEGCTA VMLKPLSAAL RDGNQIRAVI RNSVLNQDGR
TAGITVPCPK AQEEAILKAY RDAMLDLRAD YVEAHGTGTK VGDPKEAGAI AAALARGNDP
GTLLPIGSIK ANIGHTESAA GLAGLIKAVL MLEHGVIPPQ ANYEFPNPDL RLEERGLRVP
TQLERRTLRR ISVNSFGYGG TNAHVVVDAA ADAFCALSGL GRHISTQRIF FISAASEKAC
QRICAGLAKY LAKRAASQKT DTSEVLARLA FTLTKKSIHP YRLALVAQDM DALIEQLILA
ASSPIARQDR KHDARIGLVF SGQGSQYAEM GRELLSSSAT FSQSIDKACQ HLLDLGSGWN
LRKELCKPQA TTRINEPALS QPLTTAIQLA LVDLLFELNI SVSAVVGHSS GEIAAAYAAE
AISFEDAMTA SFYRGSLTSS LVVGNPECDG AMLAVGADAD VVSQRITEIG DTHGRMRVAC
FNSPNSVTVS GDSAAVNELR ARLVAEGTFN RMLPTNGAAY HSHQMEAMVK EYTLSLQKKL
SPKKATSIYA PRIFSSVTGK ENNQETPLDG AYWATNLLSP VLFSQALREM CEQKYNGKAL
DMIIEVGPHS QLGGAVKQTI KALKASDAKI AYTSVLKKSK DAQQSWLECL GALHVCTATV
DLNTSNGLSG NDVPMLLVDL PPYPFDHERS FWRETRISKD YRHRKHAPHE LLGNFSHDTN
RVEPRWRQFI SLKQTPWLKN HLVQGQIVFP GAGFITMAVQ AMRQHMHATS PLVKVHSLLL
RNVSISRALV LPADGPDVEI TLTLRPESHT AKSSSTVWSE FRIFTVTPES VWTEHCRGLV
HAETQAADVD DIAADVKDTV DASAACTHEV TPQKLYHLGR EIGLDWQHPF DNVSSIRTSR
DAVVAVARKT ISDVDVGGMG DILHPTVLDS CLFHGISAVL VLERGATSTF VPNFIEQMRI
FNRAPDSNSE LVSTSKLSQD TSTYDVVIQE RCGNPSQAVI LAAKGVHTTT LPGDTGLNEV
IGDICHSQDW VTHVDAWTPD HRNRICKSVV APASSLEDNR GLDALTLHFI QKAVKEVDPD
RVPDGPRRHF FEWMKSYAKT SLDNQSLRQA SASPGIWAFS EGVKRLGPHL ADILVDKTDP
LALLTPDGLL GQLYTTERCK RCMAQMVEYC HALGQQTPGL RVLEIGAGTA SATLPAIQAL
NGRGSTNAHS YTFTDLSPAF FEPAKERLGS FADAVIFDIL DIERCPLEQG FQEGGYDLVI
ASNVIHATRR IDSVLANIKK LLKPGGKFML MELTVPTPHY NLLFGVFKGW WAGYDEGRQL
SPLIPRSEWI TRLTRAKFSS AELWFEDYPE EEGGTMSVFI ASAPWDSAEA ELPPIDVVTT
EFSALEFGDE AVLKTTAVSE EFSNAQISIR CLSDVLSHGN VVIMLPEVAR SLCKDLDGSV
WERFKHSILN ARAVLLVGCG SSFGSDFISG GIWLGFARCL RLELPRLRII TLDISAPRSF
MMKRLASVLP PLTRSIKLGL GLQGRVELDN EFREIDGQLF VSRLVSNDKM SDYIHRSRHR
APPDLSPFLD KRRSMSAELR VPGLLESIRW KDDTKATKLG PDEVMLELRA ASINFKDVLI
AAGQLEGINE MRNDCSGVVV EVGSNMRDRF KAGDRVCALY SRSYTNYPVV HGDCCQIVPD
SMSFEEAAAL PVVWTTVYYS LVDMGRLEKG EKILIHSAAG AVGQAAIMLA KHIGAEIFAT
VGNSAKRELL RERYGIADDH IFSSRTPAFH DKIKRYTGGY GVDVVLNSLA GDQFRHSCNL
VAPFGRFVEI GRKDLMDDAR MSMGFLLKNI TFAYVDLSLI MEVKRSLARR LLQDVVKLAA
SCSIQPVTLT TLPITEIEMA FRMIQAGKHT GKIVLRVEED QKVKADPPAP TQAQLKPDAT
YLLVGGLGGL GRAIVTWMGS RGAKNILCTS RSGCSDKQGQ TLIRHMEALG VKVVAMKCDV
TAENQVASLP KAAAGCGLPP IRGVIHSAMV LQDSVFEEMT ADEWRGAIAP KVAGSLNLHR
CFGNELDFFI FLSSAVALRG NLGQCNYAAG CSFQDALARY RTAAGMSAYS INIGSVRDVG
FVSESPQVAA ALRKQGLGTI SMSDLLAMLN YAVMHPRSGH AKDSVCAIGM LPRDTDESLT
DRRFAHLVRH DLVSQTGQGS VQFADIPRLL DGTAPAEKLL ENICQLVLLQ LSKLIASPVE
TLSSAQSLDS YGVDSLVAVE LRNWVGAYLQ ANIPLMVLRG TSSIQELAKI IAKESRFVAA
SC
//