ID A0A0A2W6C3_BEABA Unreviewed; 3978 AA.
AC A0A0A2W6C3;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN ORFNames=BBAD15_g6128 {ECO:0000313|EMBL:KGQ08529.1};
OS Beauveria bassiana D1-5.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Cordycipitaceae; Beauveria.
OX NCBI_TaxID=1245745 {ECO:0000313|EMBL:KGQ08529.1, ECO:0000313|Proteomes:UP000030106};
RN [1] {ECO:0000313|EMBL:KGQ08529.1, ECO:0000313|Proteomes:UP000030106}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=D1-5 {ECO:0000313|EMBL:KGQ08529.1,
RC ECO:0000313|Proteomes:UP000030106};
RA Li Q., Wang L., Zhang Z., Wang Q., Ren J., Wang M., Xu W., Wang J., Lu Y.,
RA Du Q., Sun Z.;
RT "Genome sequencing and analysis of entomopathogenic fungi Beauveria
RT bassiana D1-5.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.26; Evidence={ECO:0000256|ARBA:ARBA00000885};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the UPL family. TOM1/PTR1 subfamily.
CC {ECO:0000256|ARBA:ARBA00034494}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGQ08529.1}.
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DR EMBL; ANFO01000569; KGQ08529.1; -; Genomic_DNA.
DR STRING; 1245745.A0A0A2W6C3; -.
DR eggNOG; KOG0939; Eukaryota.
DR HOGENOM; CLU_000215_0_1_1; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000030106; Unassembled WGS sequence.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR010309; E3_Ub_ligase_DUF908.
DR InterPro; IPR010314; E3_Ub_ligase_DUF913.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR025527; HUWE1/Rev1_UBM.
DR InterPro; IPR015940; UBA.
DR PANTHER; PTHR11254:SF67; E3 UBIQUITIN-PROTEIN LIGASE HUWE1; 1.
DR PANTHER; PTHR11254; HECT DOMAIN UBIQUITIN-PROTEIN LIGASE; 1.
DR Pfam; PF06012; DUF908; 1.
DR Pfam; PF06025; DUF913; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF14377; UBM; 3.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS50030; UBA; 1.
PE 3: Inferred from homology;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000030106};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 1463..1507
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT DOMAIN 3633..3978
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 220..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 282..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 731..773
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 920..948
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1147..1166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1509..1607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1938..2001
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2025..2068
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2304..2507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2606..2676
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2818..2843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2870..2892
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2965..2992
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3029..3071
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3290..3337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3519..3540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 289..316
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 754..772
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 922..940
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1526..1553
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1580..1605
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1938..1956
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1980..2001
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2053..2068
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2354..2403
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2419..2494
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2662..2676
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2818..2842
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2874..2892
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3318..3332
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 3945
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 3978 AA; 444082 MW; 1867380C6891C974 CRC64;
MGRITREMQP KHRDTLSPWL KSYVEAASTI SLPLLPQHLA TYPTRWPFGR GDLYHWIPLL
NRFDAILDAF CTTYKLSLGP QIEDFDSHIL RNHGGEGDFA DEKQWDDQEL QKLGYTGEGD
RELVEAILKF TRLLLEHCGN RSIYASSAHL SHILNSTSLS LLISALEVGS ELAQRYQASV
KRIGNSSRHI SAALLANHYN INLDRVQQIA QAFTKPTTAT LADSNPTATP TSHIKDKASS
QSRSTPKTHA TDLVALATSS DQRWADWGDV KIRYYPEDTK VSHDAPVEAG RSSQPSTPTP
LRRSSTVAGT TQHTPKARSA HAEEPSPVFH RTPGLTDEAD GSAQRTFDVP QSIVVSSSMK
QLMAKLPSNM SQTSRYEAFH HFRVAKALTA SQKSRQQILG ARLLAITNLA YIHTESNFVE
KVLRQDMDET RRYQLAYQLA ELIHPSSDGN AEAPLWLQTI SLALMEAISS FTSRCQDVLS
ALNANVNHGI LLYVIRKAVA GMENTKPEDD GDQVTETDNW RNNLFSLTLN LSMATRTGSE
MASSGLMDIL VHILNIRSPV AERHHSMVLA FLDGLIWAYP HAFTAFFSAD GLDAVSKLVV
DTVTEAKQLV ATSKGITQDH QSSAVDYEVP YYQQQTLKWL LKYIHRIMSN SYSYSGNTER
LLRNLAEKSD LLASLRDIIR DKTCFGSIIW TNSVLILSDF INNDPTSYAA ISESGMIKTY
LEAITGRTIT DASQEDETRD LEDGSNDVSE GSDVTAMIEK DSRPHPPTEE ALRASQHGDV
VAGGILASSE AINVVPQVLN SISLNNSGMK LVVSSRAFDS YFEIFESPEH VRCMEVDVDL
ATAIGGSFDE LARHHPPLRT AISNAVIDMV AKVRYLGIRK AEEDHWGVRL LGTDTNGRIV
SIDEHGQVAE KKGALLSARQ DSDADVTMQD SATPKVIGDN TGETSPKKKP DTVTPYIFAL
ANFLSSYLSS TFIKTNFVEK GGIELLLDIC ELPSLPASYS DSPAARAINA VVVQLVEHAP
VRSLPSLLKR AQASIDILRP LSIKTEALPP YFGQFLSPNL QIPNDELPEP LLSGTRIVKA
LLNAQNFIKI LSECFNTSRS HSLQFYPVNA YDYYLQLVKS LGPLLRGVLA EEAGELAAVP
QHWSIKRVGS SPEGEPSATN AVFENDSTSL PDVLSSTGAW KQVEGADAPK SPTEEEQRTP
RFHNYEALKL LLHPMIPTSF PLFQSIGKAL VPRREVTHGD PYPRPRHLQL AKELASTVLD
QLSPSVATPN PSSKEFHYWI IMLHTIHEML IDHQPGRQAD RTHAYIIIPV LLAFKEQGGL
DVLNSILRIF ASAVRGGTNA SRPDELSKAK VAAFGLKKIL ELHVLLVNGK YLVDTSNYFN
LQRHTDRNQV VSNIYQQIVV EFRCAILPPI LELWDSSFVE HVSDETAKRI LEILKMIAVG
GDEPTSTPKD KAPFALLNYS DVRFDWRPLR VLINDLLNVG FDEDLVHEAV FRANGNVSGA
REYCRAHKSG LAGPRNPIPI EDADVSTYKT SESSRSRQRA ASTGTSTSEP DRMSLDTFTE
DVDGDGPAGT EAHHIQESAA SEPAQVTEVE TNPTTSETSR AQFSGTKEEL DALRSKLRSN
LIDRSLDVIR THSDCAIEVS QLIQIMILRH QDRETHEEVG TVLTSALSSL ALDAEEKKKN
GKCIAAYAHL LALLLQDQTF FDNNVDGLRD KVAEYVDFLK VPSSGAADEL PPWIPYILVV
LEPLLSHDER PVAAQWLAPR TVDDPVQPAV LQLGISLISD QQRSNILESL LDLLPRVGKQ
ELLALSILRV LVILTRRRQL AKHVGQKKNL QRLFLMAKQL AGYGSERLKH HRVTSHIIAT
LRHIVEDEET LRQIIRAEIK TEFPNIQRNN HGHADVSAYL RALAPVALRA PELFVEVSNE
MLRFSRWSPA ESETAGRLNT LTLKDGTTAS NDSVPSTDAE EIKDQPSAVF ASSTADEVKP
STELADKEMA DAPKITDSKR PVVENPDGVV HFLLCELVNY REVDDKEPAN PAKDVQPELD
MSDAGSEPMD KEMNAGEGSD KKQSKPQFKS EEHPIFVYRC FLLNCLSELL QSYTRTKVEF
INFKRSAPPI STGTPIKPRT GILNYLIYDL LCQGNLAGTA DNIAAKKKLA TSAQTQRVLV
ALVSKTSEKP ASSSQEKFAY DDEPDLLFVR KFVLDTILRA YERAPLSDEP LETRYSRMQS
LAELMLHMIG DRDKDQQRSG ARVIEKNQSR SQAQIRRLMY EKGYLDKLTT SIAELSLNYP
GVKRAIKYIL RVLRILTDTA KGLSHSNLVP ADPGAEQSEE EYGESSSSLS DLEDDREETP
DLYRNSALGM LEPRDEDDES ESEDEDEDAD MYGDEYDEEM DYGDEEMSDG EDDISDDDEE
LSGMGDIEGL HGEPGVVEVI MDDDDDDDDE DEDEESDDEG DEADSADMED MEDRVEIVDE
DGNPIDDDSA WESDSDIDDN EVQPTEDVDY EAEAHDEDEA HIHGMGPRDL LDNMARAIMG
DDEGYGHDIM NGLDDHYMDD DQDDVEDDDE DEEEIEDEEY FDEDEFYAPE DHLPHLAPAG
WDGMDPEIDD RHRLLLLENN RRPVFTRMEN RGGPPSRFVG TQRDGGDFRS YFSRMHRPAG
QQNHAEDGSN PLLRRNDPET ENSSRPGNSN SFGLRLPETM FASGGRHMID GPMSFLGELM
EFLPMMGRNN NGQAFHVQIT RPGGPRAEFA PIRPGRHDQR REVSQEPFQA VAFTTESTVS
RYSEEARMIF GSNYVLEASR LSNAISAALT PAAVEHQKKV MAVDEENRKK AEEIRRKLEE
EQKEKEAKEA EERAEQERGR QAALERAAAA FEAAGSFFTE DDERLAMEAV ESLSSGEPAS
QPEASSASRV TTTIRGEEVD ITELGIDPDY LAALPEEFRE EVIAQTVSER RSQALQTAPA
GESTEVFQEF LDALPEELRL EIAQQERQEQ RRRVGNRRHA GNAGTVRPAD MDTASILQTF
PPELRDEVLL QQGQSLMDQL TPELAAQSRA LHQHHGPSGL QRGQHHGPPP TGNNSHAEAS
KAADSKPPRK TVVQMLDKAG VATLLRLMFI THQGSFRNYL FAVFADVCEN RQSRLEVIST
LLQILQDGST DVNAVERSFG QLSIKAKRLK DKERDAEPRT PQTLKRTLTS LSVSNTAQTS
SETSPLLIVQ QCLDLLVDLC ARNPHVPWLF LTEHETVGAS LRKSFGRKGK TKDSKANKYA
INALLTLLDR ELITESSLVM THLADLLNRV TMPLQNLERR RRESLDTVLV ETKKQKEGQT
SGEAQADAPA AGNEDSAQKA PKQGNVPQKR SRQLQPPVIP EENLSLVVRI FVARECSSKT
FQNTIATIKN LCAIPGTKTI FGQELIRQAR ALSQNIVTDL NELLPHILAA SSGTEIQGVA
LAKFSPGASD QNKLLRVLTA LDHLFEPKKK PSQASPDNLD DSKQDLLTSL YHNETFLSMW
DKLSRCLSAI RQRENMLSVA TILLPLIESL MVVCKNTTTK DDATPSQQTG EEPLSSPVSE
SQTASLFFSF TEEHRRILNE LVRHSPKLMS GTFALLVRNP KVLEFDNKRN YFNRTVHSRA
AHGQSRPSYP PLQLSVRRES VYRDSFANLY YKSGDEIKYG KLNIRFGGEE GVDAGGVTRE
WFQVLARQMF DPNNALFIPV SSDRTTFHPN KLSKFHLNED SNAGESTDSI HFKFIGRIIG
KALYEGRLLD CFFSRAVYKR ILGKSVSVKD MESFDPDYYK SLCWMLENDI TDIITETFSE
EEDEFGVTKI VDLIPNGREI PVTEENKQEY VRLVVEHRLL TSVKDQMESF LKGFHEIIPA
ELISIFNEQE LELLISGLPD IDIDDWRSNA EYHNYTPSSQ QVQWFWRAVR SFDKEELAKL
LQFVTGTSKV PLNGFKELEG MNGISRFNIH RDYGDKDRLP TSHTCFNQLD LPEYDSYDTL
RAQLYKAITA GNEYFGFA
//
