ID A0A0A2W6E6_BEABA Unreviewed; 1489 AA.
AC A0A0A2W6E6;
DT 04-FEB-2015, integrated into UniProtKB/TrEMBL.
DT 04-FEB-2015, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 13 {ECO:0000256|ARBA:ARBA00019618, ECO:0000256|RuleBase:RU364134};
DE AltName: Full=Mediator complex subunit 13 {ECO:0000256|ARBA:ARBA00032008, ECO:0000256|RuleBase:RU364134};
GN ORFNames=BBAD15_g6116 {ECO:0000313|EMBL:KGQ08549.1};
OS Beauveria bassiana D1-5.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Cordycipitaceae; Beauveria.
OX NCBI_TaxID=1245745 {ECO:0000313|EMBL:KGQ08549.1, ECO:0000313|Proteomes:UP000030106};
RN [1] {ECO:0000313|EMBL:KGQ08549.1, ECO:0000313|Proteomes:UP000030106}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=D1-5 {ECO:0000313|EMBL:KGQ08549.1,
RC ECO:0000313|Proteomes:UP000030106};
RA Li Q., Wang L., Zhang Z., Wang Q., Ren J., Wang M., Xu W., Wang J., Lu Y.,
RA Du Q., Sun Z.;
RT "Genome sequencing and analysis of entomopathogenic fungi Beauveria
RT bassiana D1-5.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the SRB8-11 complex. The SRB8-11 complex is a
CC regulatory module of the Mediator complex which is itself involved in
CC regulation of basal and activated RNA polymerase II-dependent
CC transcription. The SRB8-11 complex may be involved in the
CC transcriptional repression of a subset of genes regulated by Mediator.
CC It may inhibit the association of the Mediator complex with RNA
CC polymerase II to form the holoenzyme complex.
CC {ECO:0000256|ARBA:ARBA00025661, ECO:0000256|RuleBase:RU364134}.
CC -!- SUBUNIT: Component of the SRB8-11 complex, which itself associates with
CC the Mediator complex. {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364134}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 13 family.
CC {ECO:0000256|ARBA:ARBA00009354, ECO:0000256|RuleBase:RU364134}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KGQ08549.1}.
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DR EMBL; ANFO01000568; KGQ08549.1; -; Genomic_DNA.
DR STRING; 1245745.A0A0A2W6E6; -.
DR eggNOG; ENOG502QQJC; Eukaryota.
DR HOGENOM; CLU_002210_0_0_1; -.
DR Proteomes; UP000030106; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR009401; Med13_C.
DR InterPro; IPR021643; Mediator_Med13_N.
DR InterPro; IPR041285; MID_MedPIWI.
DR PANTHER; PTHR48249; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR PANTHER; PTHR48249:SF3; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR Pfam; PF06333; Med13_C; 1.
DR Pfam; PF11597; Med13_N; 1.
DR Pfam; PF18296; MID_MedPIWI; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364134};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364134};
KW Reference proteome {ECO:0000313|Proteomes:UP000030106};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364134};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364134};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364134}.
FT DOMAIN 6..361
FT /note="Mediator complex subunit Med13 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11597"
FT DOMAIN 991..1163
FT /note="MID"
FT /evidence="ECO:0000259|Pfam:PF18296"
FT DOMAIN 1172..1478
FT /note="Mediator complex subunit Med13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06333"
FT REGION 98..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 388..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 430..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 490..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 600..635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 693..780
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 925..950
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1343..1369
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..422
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 490..509
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 603..625
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 700..723
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 724..740
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 758..780
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1489 AA; 161171 MW; 0CDDC8387C05CF55 CRC64;
MDTVDSETNV LLVSNIAGVA YRFYEPSADS KQTFFSNALG IETSLREQGR IVSFDATRRG
LWYFHIRRSV GAESQGPAEL GATAVVNDQF LMSTKHGSME PSQWHKSLAP EPPTHRPNQT
SSGHAAQLQL TGSQQDHEAT AITEQTELRQ SNGFTPKVLY ESFIGALLLT ICSSFCSKSE
AVPLNFRTVL LPALKASESA TDRWIGEQAQ ALGTLKCYMI STGSLILSFS VTVCPGLASL
EDILSSNSNP IGNNILAAPF GVMTNEEQSP SSHSTGAPLA HTPTIQTLAQ RSPSNVNSSL
WKQACLAIFQ LRGVPGAALR ECSWVNLLVS KPKLQDTKPE NGRAAHSTIS IPWPGSLCFR
KKAVELSATN RISDTIVVGH DETHDPLGDA RGWLSSANER EERISKRHAE RSAAGDKENS
AVDTRLGKIN APSPVTMRRP STTGGNAVYP TPPDAIQNLN GVTPSMDGNL SSPGHPLSVV
ADVDIDCEPP GEENSVHQND DEMTEAADGK PLRSDNNLLS EAENMFEDMG GDMFGDNDIT
EADFSFFDEQ PDEMGMDMSF DSIKGSRVPS ALPINAEEPV ASASINAPPS AESAVFAKPE
LKHARSSQPE DAPQRGRDHP AKSAKRGSSP FDPDSVFKRL RAAASQRTPR GAYGVGLNRG
IKVFEKVDFD SKMPILNKKY EHGGLFDFVP NATDTDKLEP GTLPKTDYLR RHGKTRAKQQ
ADSRRPSIVK STTDPDTQLL DHQLLNLDGD ISDGDDSSSD SDIASNLSVK EPVSPVKSTV
KQSILGDDDA ASYVTTGRDQ DLAEEPDEQL ALELPRLSLL DGPDTPLFRY FTDPEPLSLD
IALSDEDMIQ VAQLVAEQAA AGSLSIFSGH SDSALSTATE EDARIEQLTS TRCALQALRD
AASSFLGTIS PVGLKTLLEV QDGSLTGQGN RVQPRQVPSK DPNSEPIKPS NLYQIPCPHL
EVRRADVRMS LLPTAVTFWE NLGLAPSSGS KDIRAVCVCP KWTGMIDNAQ VFLGRLKSTY
ETLKLGTFEN MPLSAGLEDG VLLYGVDRIS TAPDATMMGH GSALLESMET LSGAMSDLEV
VDTNVVVYFM YSTSNPGTIV EACMAFQRFF ESYRRTLVAK RESAKNEIVL QLVSADAISS
STSMVITPSS DLVKLCMETY DRCTLFGGNM PAPAIRLEQP LPRIIDFKLS PAPSSSLARE
NSCIHIAYAR SIDGRWVTAA WTDDRGNEQA TAAYCLGHKG EPETRTMNDV AHEIWQTTVE
LISTWKVHYR IIMTKCGPAD EGEIDFWVDL ARTEMHASVT MIVMTVETNP SLQLVPAPIK
MSLQPLSIYT TPVSTPQANI VSPEASAAPA TPARDTTGAV ATPGGESNGD ADVDSVLADV
MDQTWGAIVN HRLNNTVGTT SIQPALISGY LIKRTGPKAE DVPSIMEVNL VYTEASARTY
EPLLREMLSY FRGLGTLARA RGVVDRVTDV RPWHVAAAEK ALRALYILM
//
